Generic Name: Triherpine Brand Name(s): Generics only. No brands available.


What is triherpine (trifluridine) used for?

Triherpine is commonly used for the treatment of herpes infection of the eye. Herpes is a virus that lives in the body quietly until an outbreak is triggered.

Triherpine is not a cure for the infection, but treatment of an outbreak can speed up the healing of the sores/swelling in the eye and lower the risk of complications (e.g., vision loss).

How should I take triherpine (trifluridine)?

To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface. Tilt your head back, look up, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place 1 drop into the pouch as directed by your doctor.

Look down and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and press gently. This will prevent the medication from draining out. Try not to blink and do not rub your eye. Repeat these steps for your other eye if so directed. Do not rinse the dropper. Replace the dropper cap after each use.

Use this medication usually every 2 hours while awake until the eye has healed. Do not use more than 9 drops into the eye in a 24-hour period. After healing, use this medication for another 7 days, usually every 4 hours while awake (at least 5 drops per day) or as directed by your doctor.

If you are using another kind of eye medication (e.g., drops or ointments), wait at least 5 to 10 minutes before applying other medications. Use eye drops before eye ointments to allow the drops to enter the eye.

Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same times each day. Continue using it for the full time prescribed. Stopping the medication too early may result in a return of the infection.

Do not use this medication more often or use longer than prescribed because doing so may increase the risk of side effects. This medication should not be used for more than 21 days at a time.

Tell your doctor if your condition worsens, does not improve after 7 days, or does not completely heal after 14 days.

How do I store triherpine (trifluridine)?

Triherpine is best stored in the refrigerator. To prevent drug damage, do not freeze. There may be different brands of triherpine that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush triherpine down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using triherpine (trifluridine)?

Before using this drug, tell your doctor or pharmacist if:

  • You are pregnant, planning to become pregnant, or are breastfeeding.
  • You are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.
  • You have allergies to medicines, foods, or other substances.
  • You are allergic to any ingredient in triherpine drops.

Do not exceed the recommended dose or use triherpine drops for longer than prescribed without checking with your doctor.

If your condition does not improve within 7 days or if it becomes worse, check with your doctor.

Do not use triherpine drops for other eye problems without first checking with your doctor.

It is important to use triherpine drops for the full course of treatment. Failure to do so may decrease the effectiveness of triherpine drops and increase the risk that the virus will no longer be sensitive to triherpine drops and will not be able to be treated by this or certain other antivirals in the future.

Use triherpine drops with extreme caution in children younger than 6 years of age. Safety and effectiveness in this age group have not been confirmed.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using triherpine during pregnancy and breast-feeding. Please always consult with your doctor to weigh the potential benefits and risks before taking triherpine.

Side effects

What side effects can occur from triherpine (trifluridine)?

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

  • Temporary burning or stinging

Seek medical attention right away if any of these severe side effects occur:

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with triherpine (trifluridine)?

Triherpine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with triherpine (trifluridine)?

Triherpine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with triherpine (trifluridine)?

Triherpine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using triherpine (trifluridine).

What is the dose of triherpine (trifluridine) for an adult?

Instill one drop of triherpine ophthalmic solution, 1% onto the cornea of the affected eye every 2 hours while awake for a maximum daily dosage of nine drops until the corneal ulcer has completely re-epithelialized.

Following re-epithelialization, treatment for an additional 7 days of one drop every 4 hours while awake for a minimum daily dosage of five drops is recommended.

If there are no signs of improvement after 7 days of therapy or complete re-epithelialization has not occurred after 14 days of therapy, other forms of therapy should be considered.

Continuous administration of triherpine ophthalmic solution, 1% for periods exceeding 21 days should be avoided because of potential ocular toxicity.

What is the dose of triherpine (trifluridine) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is triherpine (trifluridine) available?

Triherpine is available in the following dosage forms and strengths:

  • Triherpine ophthalmic solution 5ml

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of triherpine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Review Date: April 14, 2017 | Last Modified: April 14, 2017

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