Triazolam

By Medically reviewed by hellodoktor

Generic Name: Triazolam Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: X

Uses

What is Triazolam used for?

Triazolam is used to treat a certain sleep problem (insomnia). It may help you fall asleep faster, stay asleep longer, and lessen how often you wake up during the night, so you can get a better night’s rest. Triazolam belongs to a class of drugs called sedative-hypnotics. It acts on your brain to produce a calming effect.

Use of this medication is usually limited to short treatment periods of 1 to 2 weeks or less. If your insomnia continues for a longer time, talk to your doctor to see if you need other treatment.

How should I take Triazolam?

Take this medication by mouth with or without food as directed by your doctor, usually just before you get into bed. The dosage is based on your medical condition, age, and response to treatment.

Although unlikely, this drug can rarely cause temporary short-term memory loss. To lessen the chance of this, do not take a dose of this drug unless you have time for a full night’s sleep of at least 7 to 8 hours. If you have to wake up before that, you may have some memory loss.

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.

This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. In such cases, withdrawal symptoms (such as nausea, vomiting, flushing, stomach cramps, nervousness, shakiness) may occur if you suddenly stop using this medication. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details, and report any withdrawal reactions right away.

When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.

Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details.

Tell your doctor if your condition persists after 7 to 10 days, or if it worsens.

You may have trouble sleeping the first few nights after you stop taking this medication. This is called rebound insomnia and is normal. It will usually go away after 1 or 2 nights. If this effect continues, contact your doctor.

How do I store Triazolam?

Triazolam is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Triazolam in the bathroom or the freezer. There may be different brands of Triazolam that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Triazolam down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

 

Precautions & warnings

What should I know before using Triazolam?

Before taking triazolam, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, lung/breathing problems (such as chronic obstructive pulmonary disease-COPD, sleep apnea), mental/mood problems (such as depression, thoughts of suicide), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), personal or family history of sleepwalking, a certain muscle disease (myasthenia gravis).

Since this drug makes you drowsy, do not drive, use machinery, or do anything that needs alertness until you can do it safely. Alcohol or marijuana can make you more drowsy. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially dizziness, confusion, unsteadiness, and excessive drowsiness. These side effects can increase the risk of falling.

Triazolam must not be used during pregnancy. It may harm an unborn baby. If you are a woman of childbearing age, use a reliable form of birth control while taking this drug. If you are planning pregnancy, do not take this medication. If you become pregnant or think you may be pregnant, tell your doctor right away.

This medication may pass into breast milk and have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Triazolam during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Triazolam. Triazolam is pregnancy risk category X according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Triazolam?

Dizziness or difficulty with coordination may occur. If either of these effects persists or worsens, tell your doctor or pharmacist promptly. To reduce the risk of dizziness or falling, get up slowly when rising from a sitting or lying position.

This medication may make you sleepy during the day. Tell your doctor if you have daytime drowsiness. Your dose may need to be adjusted.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: memory loss, mental/mood/behavior changes (such as new/worsening depression, abnormal thoughts, thoughts of suicide, hallucinations, confusion, agitation, aggressive behavior, anxiety).

Rarely, after taking this drug, people have gotten out of bed and driven vehicles while not fully awake (“sleep-driving”). People have also sleepwalked, prepared/eaten food, made phone calls, or had sex while not fully awake. Often, these people do not remember these events. This problem can be dangerous to you or to others. If you find out that you have done any of these activities after taking this medication, tell your doctor right away. Your risk is increased if you use alcohol or other medications that can make you drowsy while taking triazolam.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Triazolam?

A product that may interact with this drug is: sodium oxybate.

Other medications can affect the removal of triazolam from your body, which may affect how triazolam works. Examples include boceprevir, mifepristone, telaprevir, St John’s wort, certain antidepressants (such as nefazodone, SSRIs such as fluoxetine/paroxetine), azole antifungals (such as itraconazole, ketoconazole), macrolide antibiotics (such as erythromycin, clarithromycin), HIV protease inhibitors (such as lopinavir, ritonavir), HIV NNRTIs (such as delavirdine), rifamycins (such as rifampin, rifabutin), among others.

The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also cause drowsiness or breathing problems. Tell your doctor or pharmacist if you are taking other products such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana, other drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Triazolam may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Triazolam?

Triazolam may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Triazolam?

Triazolam may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Triazolam.

What is the dose of Triazolam for an adult?

Usual Adult Dose for Insomnia

Initial dose: 0.25 mg orally once a day at bedtime

Maintenance dose: 0.125 to 0.25 mg orally once a day at bedtime

Maximum dose: 0.5 mg/day

Duration of therapy: 7 to 10 days

Comments:

-Failure to respond after 7 to 10 days may suggest a primary psychiatric and/or medical illness that requires further evaluation.

-Use of this drug for more than 2 to 3 weeks requires complete reevaluation of the patient.

Use: Short-term treatment of insomnia

Usual Geriatric Dose for Insomnia

Initial dose: 0.125 mg orally once a day at bedtime

Maintenance dose: 0.125 to 0.25 mg orally once a day at bedtime

Maximum dose: 0.25 mg/day

Duration of therapy: 7 to 10 days

Comments:

-Failure to respond after 7 to 10 days may suggest a primary psychiatric and/or medical illness that requires further evaluation.

-Use of this drug for more than 2 to 3 weeks requires complete reevaluation of the patient.

-The lowest effective dose should be used to minimize the potential for oversedation.

Use: Short-term treatment of insomnia

Renal Dose Adjustments

Use with caution

Liver Dose Adjustments

Use with caution

Dose Adjustments

Debilitated patients or patients with low body weight:

-Initial dose: 0.125 mg orally once a day at bedtime

-Maintenance dose: 0.125 to 0.25 mg orally once a day at bedtime

-Maximum dose: 0.25 mg/day

Treatment withdrawal:

-Treatment should not be abruptly ceased, particularly in patients with a history of seizure.

-Tapering of the dose is recommended in any patient taking more than the lowest dose for longer than a few weeks.

Other Comments

Administration advice:

-Doses should be administered immediately before bedtime.

-Doses should not be taken where a full night’s sleep and clearance of the drug from the body are not possible before the patient would need to be active and functional, e.g., overnight flights lasting less than 7 to 8 hours.

General:

-Prescriptions for this drug should be written for short-term use; it should not be prescribed in quantities that exceed a 1-month supply.

-The elderly are more susceptible to dose-related side effects such as drowsiness, dizziness, lightheadedness, and amnesia.

-The lowest effective dose should be used.

Monitoring:

-Nervous system: Anterograde amnesia, drowsiness, dizziness

-Other: Withdrawal side effects, e.g., rebound insomnia, tolerance, dependence

-Psychiatric: Complex behaviors such as “sleep-driving”, anxiety, emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior.

Patient advice:

-Tell your healthcare provider about all of the medicines that you take, including prescription and non-prescription medicines.

-This medicine may cause drowsiness and dizziness and reduce alertness; do not drive a car or operate dangerous machinery until you know how this drug affects you.

-You may still be dizzy or drowsy the day after taking this medicine; take care as a pedestrian

-Do not drink alcohol or take other medicines that may cause sleepiness or dizziness while taking this medicine until you talk to your healthcare provider.

-Do not stop taking this medicine suddenly without first consulting your doctor.

-After taking this medicine, you may get up out of bed while not being fully awake, do an activity that you do not know you are doing, and the next morning, you may not remember that you did anything during the night. Reported activities include driving a car, making and eating food, talking on the phone, and sleep-walking. There is a greater chance of this happening if you drink alcohol or take other medicines that make you sleepy while you are taking this medicine. Contact your doctor as soon as possible if any of this occurs.

What is the dose of Triazolam for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Triazolam available?

Triazolam is available in the following dosage forms and strengths:

  • Oral tablet.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Triazolam, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: November 7, 2018 | Last Modified: September 12, 2019

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