Generic Name: Tobrex Brand Name(s): Generics only. No brands available.


What is Tobrex® (Tobramycin) used for?

Tobrex® is commonly used for treating bacterial infections of the external part of the eye.

How should I take Tobrex® (Tobramycin)?

Tobrex® Eye Ointment :

  • Wash your hands clean with soap and water.
  • Remove the cap from the tube. Using your forefinger, gently pull your lower eyelid down to form a pouch.
  • Using your other hand, carefully squeeze a small ribbon (about 1 – 1½ cm) of ointment into the pouch.
  • Making sure that the ointment remains within the eye, slowly close your eye without blinking. Keep your eye closed for 1 to 2 minutes.
  • If necessary, repeat the above steps 1-4 for your other eye.
  • Place the cap on the tube and close it tightly.
  • Wash your hands again with soap and water to remove any residue.

Tobrex® Eye Drop:

  • If you use contact lenses, make sure to remove them before you use Tobrex® drops.
  • Wash your hands. Tilt your head back.
  • Using your index finger, pull the lower eyelid away from the eye to form a pouch.
  • Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eyelid for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye.
  • Wash your hands to remove any medicine that may be on them.
  • To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.

How do I store Tobrex® (Tobramycin)?

Tobrex® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Tobrex® in the bathroom or the freezer. There may be different brands of Tobrex® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Tobrex® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Tobrex® (Tobramycin)?

Consult with your doctor or pharmacist, if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with Tobrex® or other medications.

Do not use Tobrex® if:

  • The seal on the carton was broken before you opened the product for the first time.
  • The tube/packaging shows signs of tampering.
  • The expiry date on the tube/carton has passed.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category B, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk;
  • B=No risk in some studies;
  • C=There may be some risk;
  • D=Positive evidence of risk;
  • X=Contraindicated;
  • N=Unknown.

Side effects

What side effects can occur from Tobrex® (Tobramycin)?

Tobrex® may cause these side effects, such as:

  • Eye irritation or feeling of having something in the eye;
  • Inflammation of the cornea (punctate keratitis);
  • Swollen/itchy eyelids;
  • Eye redness;
  • Increased tearing;
  • Loss of eyelashes;
  • Lightening of skin.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Tobrex® (Tobramycin)?

Tobrex® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

  • Cephalosporins by injection (e.g., ceftazidime) because they may decrease Tobrex® drops’ effectiveness.
  • Cyclosporine, fludarabine, loop diuretics (e.g., furosemide), methoxyflurane, nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., indomethacin), nitrosoureas (e.g., streptozocin), polypeptide antibiotics (e.g., polymyxin B), or vancomycin injection because they may increase the risk of Tobrex® drops’ side effects, including the risk of kidney or hearing problems.
  • Cephalosporins by injection (e.g., ceftazidime), nondepolarizing muscle relaxants (e.g., pancuronium), or succinylcholine because their side effects may be increased by Tobrex® drops.

Does food or alcohol interact with Tobrex® (Tobramycin)?

Tobrex® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Tobrex® (Tobramycin)?

Tobrex® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of Tobrex® (Tobramycin) for an adult?

Tobrex® Eye Ointment:

  • For very severe infections, apply about 1 – 1½ cm ribbonin the affected eye(s) every three to four hours.
  • In mild to moderate infections, apply about 1 – 1½ cm ribbonin the affected eye(s) two or three times per day.

Tobrex® Eye Drops:

  • In mild to moderate disease, instill 1-2 drops into the affected eye(s) every four hours.
  • In severe infections, instill 2 drops into the eye(s) hourly until improvement.

What is the dose of Tobrex® (Tobramycin) for a child?

Tobrex® Eye Ointment:

  • In mild to moderate infections, apply 1.25 cm to affected eye(s) 2-3 times a day.
  • In severe infections, apply 1.25 cm to affected eye(s) 6-8 times a day.

Tobrex® Eye Drops:

  • In mild to moderate infections, 1-2 drops 4-6 times a day, may be increased to every 1-2 hours during initial 24-48 hours.
  • In severe infections, 2 drops every 30-60 minutes, then less frequently after improvement; for P-aeruginosa, 2 drops every 5 minutes for 1 hour, then every 30 minutes.

How is Tobrex® (Tobramycin) available?

Tobrex® is available in the following dosage forms and strengths:

  • Tobrex® eye drops 0.3%.
  • Tobrex® eye ointment 3.0 mg/g.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services (115) or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Tobrex®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: November 14, 2016 | Last Modified: January 4, 2017