Tobramycin + Dexamethasone

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Generic Name: Tobramycin + Dexamethasone Brand Name(s): Generics only. No brands available.

Uses

What is Tobramycin + Dexamethasone used for?

This medication is used to treat or prevent eye infections. This medication contains two drugs. Tobramycin belongs to a class of drugs called aminoglycoside antibiotics. It works by stopping the growth of bacteria. Dexamethasone belongs to a class of drugs called corticosteroids. It works by reducing swelling.

This medication treats/prevents only bacterial eye infections. It will not work for other types of eye infections. Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness.

How should I take Tobramycin + Dexamethasone?

To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface. Shake the bottle well before each dose.

Do not wear contact lenses while you are using this medicine. Sterilize contact lenses according to manufacturer’s directions and check with your doctor before you begin using them again.

Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place one drop into the pouch. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. This will prevent the medication from draining out. Try not to blink and do not rub your eye. Repeat these steps for your other eye if so directed, and if your dose is for more than 1 drop. Your dosage is based on your medical condition and response to therapy.

Do not rinse the dropper. Replace the dropper cap after each use.

If you are using another kind of eye medication (e.g., drops or ointments), wait at least 5 to 10 minutes before applying other medications. Use eye drops before eye ointments to allow the eye drops to enter the eye.

Use this medication regularly in order to get the most benefit from it. Remember to use it at the same times each day. Continue to use this medication for the full time prescribed, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a relapse of the infection.

Inform your doctor if your condition persists or worsens.

How do I store Tobramycin + Dexamethasone?

Tobramycin + Dexamethasone is best stored at room temperature away from direct light and moisture. Store upright with the cap on. To prevent drug damage, you should not store Tobramycin + Dexamethasone in the bathroom or the freezer. There may be different brands of Tobramycin + Dexamethasone that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Tobramycin + Dexamethasone down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Tobramycin + Dexamethasone?

Before using tobramycin with dexamethasone, tell your doctor or pharmacist if you are allergic to either drug; or to other aminoglycoside antibiotics (e.g., gentamicin); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other eye problems (e.g., glaucoma, cataracts).

Your vision may be temporarily unstable after applying this drug. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known if this medication passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Tobramycin + Dexamethasone during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Tobramycin + Dexamethasone. Tobramycin + Dexamethasone is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Tobramycin + Dexamethasone?

Eye redness, eye discomfort, and eyelid itching/swelling may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Use of this medication for prolonged/repeated periods may result in a new fungal eye infection and may increase your risk for other eye problems (e.g., glaucoma, cataracts). Do not use this medication for longer than prescribed. Tell your doctor right away if you notice any of the following: new or worsening eye symptoms (e.g., discharge, swelling), vision changes, eye pain.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Tobramycin + Dexamethasone?

Tobramycin + Dexamethasone may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Tobramycin + Dexamethasone?

Tobramycin + Dexamethasone may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Tobramycin + Dexamethasone?

Tobramycin + Dexamethasone may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Tobramycin + Dexamethasone.

What is the dose of Tobramycin + Dexamethasone for an adult?

Usual Adult Dose for Uveitis

Suspension: 1 or 2 drops into the conjunctival sac(s) every 4 to 6 hours

Ointment: Apply a small amount (approximately 1/2 inch ribbon) into the conjunctival sac(s) up to 3 or 4 times per day

Comments:

SUSPENSION:

-During the initial 24 to 48 hours, the dosage may be increased to 1 or 2 drops every 2 hours.

-Frequency should be decreased gradually as indicated by improvement in clinical signs.

-No more than 20 mL should be prescribed initially and the prescription should not be refilled without additional evaluation.

OINTMENT:

-No more than 8 g should be prescribed initially and the prescription should not be refilled without further evaluation.

Use: Steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists

Usual Adult Dose for Bacterial Conjunctivitis

Suspension: 1 or 2 drops into the conjunctival sac(s) every 4 to 6 hours

Ointment: Apply a small amount (approximately 1/2 inch ribbon) into the conjunctival sac(s) up to 3 or 4 times per day

Comments:

SUSPENSION:

-During the initial 24 to 48 hours, the dosage may be increased to 1 or 2 drops every 2 hours.

-Frequency should be decreased gradually as indicated by improvement in clinical signs.

-No more than 20 mL should be prescribed initially and the prescription should not be refilled without additional evaluation.

OINTMENT:

-No more than 8 g should be prescribed initially and the prescription should not be refilled without further evaluation.

Use: Steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists

Usual Adult Dose for Keratitis

Suspension: 1 or 2 drops into the conjunctival sac(s) every 4 to 6 hours

Ointment: Apply a small amount (approximately 1/2 inch ribbon) into the conjunctival sac(s) up to 3 or 4 times per day

Comments:

SUSPENSION:

-During the initial 24 to 48 hours, the dosage may be increased to 1 or 2 drops every 2 hours.

-Frequency should be decreased gradually as indicated by improvement in clinical signs.

-No more than 20 mL should be prescribed initially and the prescription should not be refilled without additional evaluation.

OINTMENT:

-No more than 8 g should be prescribed initially and the prescription should not be refilled without further evaluation.

Use: Steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists

What is the dose of Tobramycin + Dexamethasone for a child?

Usual Pediatric Dose for Uveitis

2 years or older:

Suspension: 1 or 2 drops into the conjunctival sac(s) every 4 to 6 hours

Ointment: Apply a small amount (approximately 1/2 inch ribbon) into the conjunctival sac(s) up to 3 or 4 times per day

Comments:

SUSPENSION:

-During the initial 24 to 48 hours, the dosage may be increased to 1 or 2 drops every 2 hours.

-Frequency should be decreased gradually as indicated by improvement in clinical signs.

-No more than 20 mL should be prescribed initially and the prescription should not be refilled without additional evaluation.

OINTMENT:

-No more than 8 g should be prescribed initially and the prescription should not be refilled without further evaluation.

Use: Steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists

Usual Pediatric Dose for Bacterial Conjunctivitis

2 years or older:

Suspension: 1 or 2 drops into the conjunctival sac(s) every 4 to 6 hours

Ointment: Apply a small amount (approximately 1/2 inch ribbon) into the conjunctival sac(s) up to 3 or 4 times per day

Comments:

SUSPENSION:

-During the initial 24 to 48 hours, the dosage may be increased to 1 or 2 drops every 2 hours.

-Frequency should be decreased gradually as indicated by improvement in clinical signs.

-No more than 20 mL should be prescribed initially and the prescription should not be refilled without additional evaluation.

OINTMENT:

-No more than 8 g should be prescribed initially and the prescription should not be refilled without further evaluation.

Use: Steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists

Usual Pediatric Dose for Keratitis

2 years or older:

Suspension: 1 or 2 drops into the conjunctival sac(s) every 4 to 6 hours

Ointment: Apply a small amount (approximately 1/2 inch ribbon) into the conjunctival sac(s) up to 3 or 4 times per day

Comments:

SUSPENSION:

-During the initial 24 to 48 hours, the dosage may be increased to 1 or 2 drops every 2 hours.

-Frequency should be decreased gradually as indicated by improvement in clinical signs.

-No more than 20 mL should be prescribed initially and the prescription should not be refilled without additional evaluation.

OINTMENT:

-No more than 8 g should be prescribed initially and the prescription should not be refilled without further evaluation.

Use: Steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists

Precautions

Safety and efficacy have not been established in patients younger than 2 years.

How is Tobramycin + Dexamethasone available?

Tobramycin + Dexamethasone is available in the following dosage forms and strengths:

  • Ophthalmic suspension,
  • Ophthalmic ointment.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Tobramycin + Dexamethasone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: June 2, 2018 | Last Modified: June 2, 2018

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