Tirofiban

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Generic Name: Tirofiban Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: B

Uses

What is Tirofiban used for?

Tirofiban keeps the platelets in your blood from coagulating (clotting) to prevent unwanted blood clots that can occur with certain heart or blood vessel conditions.

Tirofiban is used to prevent blood clots or heart attack in people with severe chest pain or other conditions, and in those who are undergoing a procedure called angioplasty (to open blocked arteries).

Tirofiban may also be used for purposes other than those listed in this medication guide.

How should I take Tirofiban?

Tirofiban is injected into a vein through an IV. A healthcare provider will give you this injection.

While using tirofiban, you may need frequent blood tests.

How do I store Tirofiban?

Tirofiban is best stored at 25°C (77°F); excursions are permitted between 15°C and 30°C (59°F and 86°F); do not freeze. Protect from light during storage. Discard any unused portion.

There may be different brands of Tirofiban that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Tirofiban down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Tirofiban?

It is very important that your doctor check you at regular visits after you leave the hospital for any problems that may be caused by this medicine. Blood and urine tests will be needed to check for unwanted effects. Be sure to keep all appointments.

You may bleed and bruise more easily while you are using this medicine. Be extra careful to avoid injuries until the effects of the medicine have worn off.

Check with your doctor right away if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin. Avoid picking your nose. If you need to blow your nose, blow it gently.

You may be told to use a soft toothbrush or to shave with an electric razor (not a razor blade) for a few days after you have been given this medicine. This helps reduce the risk of bleeding.

Watch for any bleeding from open areas such as sites of needle punctures for drawing blood, giving shots, or putting in a catheter for a heart catheterization or angioplasty. Also check for blood in your urine or bowel movements. If you have any bleeding or injuries, tell your doctor right away.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter/OTC) medicines and herbal or vitamin supplements.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Tirofiban during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Tirofiban. Tirofiban is pregnancy risk category B according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Tirofiban?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • Nosebleed or other bleeding that will not stop;
  • Black, bloody, or tarry stools;
  • Coughing up blood or vomit that looks like coffee grounds;
  • Chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • Sudden numbness or weakness, especially on one side of the body;
  • Sudden headache, confusion, problems with vision, speech, or balance;
  • Fever, chills, body aches, flu symptoms; or
  • Pale skin, easy bruising or bleeding, weakness, fever, and urinating more or less than usual.

Less serious side effects may also occur, such as:

  • Nausea, stomach pain;
  • Runny or stuffy nose, cough, sore throat; or
  • Mild headache or dizziness.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Tirofiban?

Before receiving tirofiban, tell your doctor if you are using any of the following drugs:

  • phenytoin (Dilantin);
  • tamoxifen (Nolvadex);
  • tolbutamide (Orinase);
  • torsemide (Demadex);
  • fluvastatin (Lescol);
  • a blood thinner such as warfarin (Coumadin), heparin, ardeparin (Normiflo), dalteparin (Fragmin), danaparoid (Orgaran), enoxaparin (Lovenox), or tinzaparin (Innohep); or
  • any other medications used to prevent blood clots, such as alteplase (Activase), anistreplase (Eminase), clopidogrel (Plavix), dipyridamole (Persantine), streptokinase (Kabikinase, Streptase), ticlopidine (Ticlid), or urokinase (Abbokinase).

If you are using any of these drugs, you may not be able to receive tirofiban, or you may need dosage adjustments or special tests during treatment.

Tirofiban may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Tirofiban?

Tirofiban may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Tirofiban?

Tirofiban may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Tirofiban.

What is the dose of Tirofiban for an adult?

Usual Adult Dose for Acute Coronary Syndrome

Initial dose: 25 mcg/kg IV within 5 minutes

Maintenance dose: 0.15 mcg/kg/min IV infusion for up to 18 hours

Use: To reduce the rate of thrombotic cardiovascular events in patients with non-ST elevation acute coronary syndrome (NSTE-ACS).

Renal Dose Adjustments

CrCl greater than 60 mL/min: Data not available

CrCl 60 mL/min or less: Following usual bolus dose, initiate constant infusion at 0.075 mcg/kg/min.

What is the dose of Tirofiban for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Tirofiban available?

Tirofiban is available in the following dosage forms and strengths:

  • Intravenous solution.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Tirofiban, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: August 9, 2018 | Last Modified: August 9, 2018

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