Tiopronin

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Generic Name: Tiopronin Brand Name(s): Generics only. No brands available.

Uses

What is Tiopronin used for?

Tiopronin is used to prevent kidney stones in patients with a certain inherited disorder (cystinuria). Cystinuria occurs when there is too much of a certain natural substance (the amino acid cystine) in the urine, leading to formation of kidney stones. Tiopronin works by making cystine more dissolvable in the urine.

This medication is usually used only after other methods are not successful in preventing kidney stones (e.g., drinking plenty of water, alkali therapy, special diet) or when patients cannot take the usual medication (d-penicillamine) for cystinuria.

How should I take Tiopronin?

Take this medication by mouth 1 hour before or 2 hours after meals, usually 3 times daily or as directed by your doctor.

Continue to drink plenty of water (e.g., 2 glasses of water with each meal, at bedtime, and during the night) and to take the alkali medication (e.g., potassium citrate) as directed by your doctor. Closely follow the diet recommended by your doctor.

Dosage is based on your medical condition and response to therapy. In children, the dose is also based on weight.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Inform your doctor if your condition persists or worsens.

How do I store Tiopronin?

Tiopronin is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Tiopronin in the bathroom or the freezer. There may be different brands of Tiopronin that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Tiopronin down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Tiopronin?

Before taking tiopronin, tell your doctor or pharmacist if you are allergic to this medication or have had very severe side effects (e.g., blood disorders) from it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood disorders (e.g., anemia, low platelet count), liver disease, kidney disease.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This drug may pass into breast milk and could have undesirable effects on a nursing infant. Therefore, breast-feeding is not recommended while using this drug. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Tiopronin during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Tiopronin. Tiopronin is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Tiopronin?

Decreased sense of taste/smell, nausea, vomiting, loss of appetite, abdominal pain, or diarrhea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: signs of infection (e.g., fever, persistent sore throat), muscle/joint pain, swelling of lymph nodes, wrinkling/thinning skin, tiredness, fast/pounding heartbeat, easy bruising/bleeding, coughing up blood, signs of kidney problems (such as change in the amount of urine, painful urination, cloudy/bloody urine), dark urine, shortness of breath, muscle weakness, seizures, numbness/tingling of the arms/legs.

Tell your doctor right away if any of these rare but very serious side effects occur: yellowing skin/eyes, persistent nausea/vomiting, severe abdominal/stomach pain.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Tiopronin?

Tiopronin may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Tiopronin?

Tiopronin may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Tiopronin?

Tiopronin may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Tiopronin.

What is the dose of Tiopronin for an adult?

Used in patients with severe homozygous cystinuria who have urinary cystine >500 mg/day; who are resistant to conservative treatment measures (high fluid intake, alkali and diet modification); or who have adverse reactions to d-penicillamine. Initial: 800 mg/day; average dose is 1000 mg/day along with adequate hydration and alkalinisation of urine. Administer in 3 divided doses whenever possible. May initiate treatment at a lower dose in patients who had severe toxicity to d-penicillamine. Adjust dose based on urinary cystine values (to reduce urinary cystine concentration to generally <250 mg/mL). Measure urinary cystine one mth after treatment, and every 3 mth thereafter.

What is the dose of Tiopronin for a child?

Initial: 15 mg/kg/day. Adjust dose based on urinary cystine values. Measure urinary cystine one mth after treatment, and every 3 mth thereafter. Administer in 3 divided doses whenever possible.

How is Tiopronin available?

Tiopronin is available in the following dosage forms and strengths:

  • Oral tablet.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Tiopronin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: June 2, 2018 | Last Modified: June 2, 2018