Generic Name: Tinidazole Brand Name(s): Generics only. No brands available.

Uses

What is Tinidazole used for?

Tinidazole is an antibiotic that is used to treat certain types of vaginal infections (bacterial vaginosis, trichomoniasis). It is also used to treat certain types of parasite infections (giardiasis, amebiasis). It works by stopping the growth of certain bacteria and parasites.

This antibiotic treats only certain bacterial and parasitic infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.

How should I take Tinidazole?

Take this medication by mouth as directed by your doctor, usually once daily. To prevent stomach upset, take this medication with food. The dosage is based on your medical condition and response to treatment. For children, the dosage is also based on weight.

For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day.

Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a short time. Stopping the medication too early may result in a return of the infection.

Tell your doctor if your condition lasts or gets worse.

How do I store Tinidazole?

Tinidazole is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Tinidazole in the bathroom or the freezer. There may be different brands of Tinidazole that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Tinidazole down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Tinidazole?

Before taking tinidazole, tell your doctor or pharmacist if you are allergic to it; or to other antibiotics (such as metronidazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney dialysis, certain blood disorders (low blood cell counts).

Avoid alcoholic beverages and products containing propylene glycol while taking this medication and for at least 3 days after finishing this medicine because severe stomach upset/cramps, nausea, vomiting, headache, and flushing may occur.

This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana.

Tinidazole may cause live bacterial vaccines (such as typhoid vaccine) to not work as well. Do not have any immunizations/vaccinations while using this medication unless your doctor tells you to.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. It is not recommended for use during the first 3 months of pregnancy. Discuss the risks and benefits with your doctor. If you become pregnant or think you may be pregnant, tell your doctor right away.

This drug passes into breast milk and could have undesirable effects on a nursing infant. Breast-feeding is not recommended while using this drug and for at least 3 days after finishing this medicine. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Tinidazole during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Tinidazole. Tinidazole is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Tinidazole?

Bitter/metallic taste in your mouth, nausea, stomach upset, diarrhea, or dizziness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

This medication may cause your urine to turn darker in color. This effect is harmless and will disappear when the medication is stopped.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: signs of a new infection (such as sore throat that doesn’t go away, fever), easy bruising/bleeding.

Get medical help right away if you have any very serious side effects, including: unsteadiness, seizures, numbness/tingling of arms/legs.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Tinidazole?

Some products that may interact with this drug include: alcohol-containing products (such as cough and cold syrups, aftershave), products containing propylene glycol, lopinavir/ritonavir solution, lithium.

Do not take tinidazole if you are also taking disulfiram or if you have taken disulfiram within the last 2 weeks.

Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such as rifampin, rifabutin) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control, ask your doctor or pharmacist for more details.

This medication may interfere with certain lab tests, possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Tinidazole may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Tinidazole?

Tinidazole may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Tinidazole?

Tinidazole may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Tinidazole.

What is the dose of Tinidazole for an adult?

Usual Adult Dose for Trichomoniasis

2 g orally once

Comments:

-Appropriate diagnostic procedures should be used to identify organism.

-The patient’s sexual partner(s) should be treated with the same dose at the same time to prevent reinfection.

-Current guidelines should be consulted for additional information.

Use: For the treatment of trichomoniasis due to Trichomonas vaginalis

Usual Adult Dose for Giardiasis

2 g orally once

Use: For the treatment of giardiasis due to Giardia lamblia

Usual Adult Dose for Amebiasis

2 g orally once a day

Duration of Therapy:

-Intestinal: 3 days

-Amebic liver abscess: 3 to 5 days

Comments:

-This drug is not indicated to treat asymptomatic cyst passage.

Use: For the treatment of intestinal amebiasis and amebic liver abscess due to Entamoeba histolytica

Some Experts Recommend: 2 g orally once a day

Duration of Therapy:

-Mild to moderate intestinal disease: 3 days

-Severe intestinal and extraintestinal disease: 5 days

Comments:

-Treatment with a luminal amebicide should follow this 3- or 5-day therapy.

-Current guidelines should be consulted for additional information.

Usual Adult Dose for Bacterial Vaginosis

2 g orally once a day for 2 days OR 1 g orally once a day for 5 days

Comments:

-Formerly referred to as Haemophilus vaginitis, Gardnerella vaginitis, nonspecific vaginitis, or anaerobic vaginosis

-Should rule out other pathogens commonly associated with vulvovaginitis (e.g., T vaginalis, Chlamydia trachomatis, Neisseria gonorrhoeae, Candida albicans, Herpes simplex virus)

-Use of this drug in pregnant women has not been studied.

Use: For the treatment of bacterial vaginosis in nonpregnant women

Usual Adult Dose for STD Prophylaxis

US CDC Recommendations: 2 g orally in a single dose

Comments:

-Recommended as part of a regimen for prophylaxis after sexual assault

-Current guidelines should be consulted for additional information.

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Caution recommended.

Dialysis

Hemodialysis: If this drug is administered the same day as and prior to hemodialysis session, an additional dose equal to 1/2 the recommended dose should be administered after the end of the session.

Peritoneal dialysis: Data not available

Other Comments

Administration advice:

-Administer with food (to minimize epigastric distress and other gastrointestinal side effects); bioavailability not affected by food.

-For patients unable to swallow tablets, may crush the tablets in artificial cherry syrup and administer with food; shake the oral suspension well before each administration.

Storage requirements:

-Store tablets at controlled room temperature 20C to 25C (68F to 77F), excursions permitted to 15C to 30C (59F to 86F); protect from light.

-The oral suspension of crushed tablets in artificial cherry syrup is stable for 7 days at room temperature.

Reconstitution/preparation techniques:

-For extemporaneous pharmacy compounding of the oral suspension:

(a) Crush four 500 mg oral tablets to a powder with mortar and pestle.

(b) Add about 10 mL cherry syrup to the powder and mix until smooth.

(c) Transfer the suspension to a graduated amber container.

(d) Use several small rinses of cherry syrup to transfer any remaining drug in the mortar to the final suspension for a total volume of 30 mL.

Monitoring:

-Hematologic: Total and differential leukocyte counts (if retreatment is necessary)

Patient advice:

-Avoid alcoholic beverages and ethanol- or propylene glycol-containing preparations during therapy and for 72 hours after the last dose.

-Avoid missing doses and complete the entire course of therapy.

What is the dose of Tinidazole for a child?

Usual Pediatric Dose for Giardiasis

3 years or older: 50 mg/kg orally once

Maximum dose: 2 g/dose

Use: For the treatment of giardiasis due to G lamblia

Usual Pediatric Dose for Amebiasis

3 years or older: 50 mg/kg orally once a day

Maximum dose: 2 g/day

Duration of Therapy:

-Intestinal: 3 days

-Amebic liver abscess: 3 to 5 days

Comments:

-This drug is not indicated to treat asymptomatic cyst passage.

-Limited pediatric data on use beyond 3 days; small number of children treated for 5 days had no additional reported side effects. Close monitoring is recommended when duration of therapy exceeds 3 days.

Use: For the treatment of intestinal amebiasis and amebic liver abscess due to E histolytica

Some Experts Recommend:

3 years or older: 50 mg/kg orally once a day

Maximum dose: 2 g/day

Duration of Therapy:

-Mild to moderate intestinal disease: 3 days

-Severe intestinal and extraintestinal disease: 5 days

Comments:

-Treatment with a luminal amebicide should follow this 3- or 5-day therapy.

-Current guidelines should be consulted for additional information.

Usual Pediatric Dose for Trichomoniasis

Some Experts Recommend: 50 mg/kg orally once

Maximum dose: 2 g/dose

Comments:

-Recommended for trichomoniasis due to T vaginalis

-The patient’s sexual partner(s) should be treated with the same dose at the same time.

-Current guidelines should be consulted for additional information.

Usual Pediatric Dose for STD Prophylaxis

American Academy of Pediatrics Recommendations: 2 g orally in a single dose

Comments:

-Recommended as part of a regimen for postpubertal adolescents as prophylaxis after sexual assault; recommended for trichomoniasis and bacterial vaginosis

-Current guidelines should be consulted for additional information.

Precautions

Safety and efficacy have not been established in patients younger than 3 years.

How is Tinidazole available?

Tinidazole is available in the following dosage forms and strengths:

  • Oral tablet,
  • Compounding powder.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Tinidazole, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

 

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: June 2, 2018 | Last Modified: June 2, 2018

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