Timolol + Dorzolamide

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Generic Name: Timolol + Dorzolamide Brand Name(s): Generics only. No brands available.

Uses

What is Timolol + Dorzolamide used for?

Timolol + Dorzolamide is used to treat high pressure inside the eye due to glaucoma (open angle-type) or other eye diseases (e.g., ocular hypertension). Lowering high pressure inside the eye helps to prevent blindness. This medication works by decreasing the amount of fluid within the eye. Timolol belongs to a class of drugs known as beta-blockers, and dorzolamide belongs to a class of drugs known as carbonic anhydrase inhibitors.

How should I take Timolol + Dorzolamide?

This medication is for use in the eye(s), usually one drop in the affected eye(s) 2 times a day, or as directed by your doctor.

To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.

Some products contain a preservative that may be absorbed by contact lenses. If you are using a product with a preservative and you wear contact lenses, remove the lenses before using the eye drops. Wait at least 15 minutes before putting in your contact lenses.

Tilt your head back, look upward and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place one drop in your eye. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. Try not to blink and do not rub your eye. This will prevent the medication from draining out. Repeat these steps for your other eye if so directed.

Do not rinse the dropper. Replace the dropper cap after each use.

If you are using another kind of eye medication (e.g., drops or ointments), wait at least 5 minutes before applying other medications. Use eye drops before eye ointments to allow the eye drops to enter the eye.

Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same times each day. It is important to continue using this medication even if you feel well. Most people with glaucoma or high pressure in the eyes do not feel sick.

How do I store Timolol + Dorzolamide?

Timolol + Dorzolamide is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Timolol + Dorzolamide in the bathroom or the freezer. There may be different brands of Timolol + Dorzolamide that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Timolol + Dorzolamide down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Timolol + Dorzolamide?

Before using timolol/dorzolamide, tell your doctor or pharmacist if you are allergic to these drugs; or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: lung disease (e.g., asthma, chronic obstructive pulmonary disease), certain types of irregular heartbeats (e.g., sinus bradycardia, second or third degree AV block), certain types of heart disease (e.g., heart failure), kidney disease (e.g., kidney stones), liver disease, diabetes, overactive thyroid disease, muscle weakness disorders, low blood flow to the brain (cerebrovascular insufficiency), severe allergies.

If you develop an eye infection or injury, or have eye surgery, check with your doctor about whether you should continue to use your current bottle of timolol/dorzolamide. You may be advised to start using a new bottle.

Before having surgery, tell your doctor or dentist that you are using this medication.

If you have diabetes, this product may prevent the fast/pounding heartbeat you would usually feel when your blood sugar level falls too low (hypoglycemia). Other symptoms of low blood sugar, such as dizziness and sweating, are unaffected by this drug.

This drug may cause temporary blurred vision. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

This drug passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Timolol + Dorzolamide during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Timolol + Dorzolamide. Timolol + Dorzolamide is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Timolol + Dorzolamide?

Temporary blurred vision, temporary burning/stinging/itching/redness of the eye, watery eyes, dry eyes, feeling as if something is in the eye, sensitivity of eyes to light, strange taste in the mouth, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: dizziness, slow/irregular heartbeat, muscle weakness, mental/mood changes, coldness/numbness/pain in the hands or feet, vision changes, signs of a kidney stone (e.g., pain in the back/side/abdomen, nausea/vomiting, blood in the urine), yellowing eyes or skin, dark urine, unusual tiredness/weakness, easy bruising/bleeding, signs of infection (e.g., fever, chills, persistent sore throat).

Get medical help right away if you have any very serious side effects, including: persistent eye redness or discharge, eye or eyelid swelling, eye pain, sudden unexplained weight gain, chest pain, weakness on one side of the body, slurred speech, confusion, persistent dizziness, fainting.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Timolol + Dorzolamide?

Some products that may interact with this drug include: high doses of aspirin or related salicylates, oral beta-blockers (e.g., propranolol), oral carbonic anhydrase inhibitors (e.g., acetazolamide, methazolamide), clonidine, certain antidepressants (e.g., SSRIs such as fluoxetine), digoxin, epinephrine, fingolimod, methyldopa, quinidine, reserpine.

Low-dose aspirin, as prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention (usually these dosages are 81-325 milligrams per day), should be continued. Consult your doctor or pharmacist for more details.

Timolol + Dorzolamide may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Timolol + Dorzolamide?

Timolol + Dorzolamide may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Timolol + Dorzolamide?

Timolol + Dorzolamide may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Timolol + Dorzolamide.

What is the dose of Timolol + Dorzolamide for an adult?

Usual Adult Dose for Intraocular Hypertension

1 drop in the affected eye(s) 2 times per day

Comments:

-If more than one topical ophthalmic drug is being used, the drugs should be administered at least ten minutes apart.

-The solution from one individual unit is to be used immediately after opening for administration to one or both eyes.

-The remaining contents should be discarded immediately after administration.

Use: To reduce elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers (failed to achieve target IOP determined after multiple measurements over time)

Usual Adult Dose for Glaucoma (Open Angle)

1 drop in the affected eye(s) 2 times per day

Comments:

-If more than one topical ophthalmic drug is being used, the drugs should be administered at least ten minutes apart.

-The solution from one individual unit is to be used immediately after opening for administration to one or both eyes.

-The remaining contents should be discarded immediately after administration.

Use: To reduce elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers (failed to achieve target IOP determined after multiple measurements over time)

Renal Dose Adjustments

Mild to moderate renal impairment: Data not available

Severe renal impairment (CrCl less than 30 mL/min): Not recommended

Liver Dose Adjustments

Hepatic impairment: Use with caution

Other Comments

Patient advice:

-Patients should be instructed to wash their hands before use and avoid allowing the tip of the container to come into contact with the eye or surrounding structures.

Storage requirements:

-Protect from light.

-Do not freeze.

What is the dose of Timolol + Dorzolamide for a child?

Usual Pediatric Dose for Intraocular Hypertension

2 years or older:

1 drop in the affected eye(s) 2 times per day

Comments:

-If more than one topical ophthalmic drug is being used, the drugs should be administered at least ten minutes apart.

-The solution from one individual unit is to be used immediately after opening for administration to one or both eyes.

-The remaining contents should be discarded immediately after administration.

Use: To reduce elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers (failed to achieve target IOP determined after multiple measurements over time)

Usual Pediatric Dose for Glaucoma (Open Angle)

2 years or older:

1 drop in the affected eye(s) 2 times per day

Comments:

-If more than one topical ophthalmic drug is being used, the drugs should be administered at least ten minutes apart.

-The solution from one individual unit is to be used immediately after opening for administration to one or both eyes.

-The remaining contents should be discarded immediately after administration.

Use: To reduce elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to beta-blockers (failed to achieve target IOP determined after multiple measurements over time)

Precautions

Safety and efficacy have not been established in patients younger than 2 years.

How is Timolol + Dorzolamide available?

Timolol + Dorzolamide is available in the following dosage forms and strengths:

  • Ophthalmic solution.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Timolol + Dorzolamide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: May 10, 2018 | Last Modified: May 10, 2018

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