By Medically reviewed by hellodoktor

Generic Name: Tildiem Brand Name(s): Tildiem.


What is Tildiem® (diltiazem hydrochloride) used for?

Tildiem® is commonly used for prophylactic treatment of angina pectoris, especially in effort angina induced by exercise and spontaneous angina (Prinzmetal’s angina).

Tildiem® may be prescribed for other uses; ask your doctor or pharmacist for more information.

How should I take Tildiem® (diltiazem hydrochloride)?

Do not crush, break, or chew the tablets. Swallow Tildiem® whole with a glass of water.

Ask your health care provider any questions you may have about how to use Tildiem®.

How do I store Tildiem® (diltiazem hydrochloride)?

Tildiem® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Tildiem® in the bathroom or the freezer. There may be different brands of Tildiem® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Tildiem® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Tildiem® (diltiazem hydrochloride)?

Consult with your doctor or pharmacist, if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Tildiem® or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You have any other types of allergies, such as to foods, dyes, preservatives, or animals.

Is it safe during pregnancy or breastfeeding?


There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown


Drug enters breast milk; because of risk for serious adverse reactions in nursing infants from diltiazem, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Always consult your health care provider prior to using this medication if you are pregnant, breastfeeding.

Side effects

What side effects can occur from Tildiem® (diltiazem hydrochloride)?

Here are side effects:

  • Swelling or flushing (feeling hot suddenly)
  • Headache
  • Nausea
  • Vomiting
  • Constipation
  • Diarrhea
  • Indigestion
  • Gastric pain
  • Dizziness
  • Confusion
  • Hallucinations
  • Abnormal dreams
  • Mental depression
  • Mood changes
  • Trouble sleeping
  • Nervousness
  • Tremor
  • Ringing or other persistent noise in the ears
  • Loss of memory
  • Dry mouth
  • Loss of appetite
  • Weight increase
  • Increased sensitivity to the sun
  • Unusual movements or uncontrollable movements
  • Rash or an itchy
  • Burning or prickly sensation
  • Small round
  • Raised itchy areas on the skin
  • Weakness or tiredness

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.



What drugs may interact with Tildiem® (diltiazem hydarochloride)?

Tildiem® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Some medicines may interfere with Tildiem® include:

  • Dantrolene
  • Heart or high blood pressure medicines (e.g., beta blockers, digoxin, amiodarone, nitrates)
  • Cyclosporin
  • Rifampicin (an antibiotic)
  • Cimetidine or ranitidine (for ulcers or reflux)
  • Diazepam (for depression, alcohol withdrawal or anxiety)
  • Carbamazepine (for bipolar disorder or epilepsy)
  • Lithium (for bipolar disorder)
  • Theophylline (for asthma and other breathing problems)
  • Prostate drugs
  • Inhaled anesthetic agents such as halothane, isoflurane, enflurane
  • Blood cholesterol drugs (including simvastatin, lovastatin)
  • Benzodiazepines or medicines used as sedatives or to treat anxiety (such as midazolam, triazolam)
  • Corticosteroids (such as methylprednisolone, prednisone, cortisone)
  • Antiarrhythmics or medicines used to treat irregular heartbeats


Does food or alcohol interact with Tildiem® (diltiazem hydrochloride)?

Tildiem® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.


What health conditions may interact with Tildiem® (diltiazem hydrochloride)?

Tildiem® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • Abnormal heart beat rhythm
  • Hypotension (low blood pressure)
  • Heart attack or other heart related complications
  • Impaired renal (kidney) or hepatic (liver) function
  • Diabetes


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of Tildiem® (diltiazem hydrochloride) for an adult?


  • The usual dose is one tablet (60mg) three times daily.
  • If necessary, the divided dose may be increased to 360mg/day.
  • Higher doses up to 480mg/day have been used with benefit in some patients especially in unstable angina.

Elderly and patients with impaired hepatic or renal function: 

  • The recommended starting dose is one tablet (60mg) twice daily.
  • The heart rate should be measured regularly in these groups of patients and the dose should not be increased if the heart rate falls below 50 beats per minute.

What is the dose of Tildiem® (diltiazem hydrochloride) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Tildiem® (diltiazem hydrochloride) available?

Tildiem® is available in the following dosage forms and strengths:

  • Tildiem® 60mg diltiazem Modified-Release Tablets

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

It is also important to carry a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking with you in case of emergencies.

What should I do if I miss a dose?

If you miss a dose of Tildiem®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.



Review Date: December 29, 2016 | Last Modified: September 12, 2019

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