Ticlopidine

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Generic Name: Ticlopidine Brand Name(s): Generics only. No brands available.

Uses

What is Ticlopidine used for?

Ticlopidine is used to prevent strokes in people who cannot take aspirin or for whom aspirin has failed to work. It may also be used in combination with aspirin following certain types of heart procedures (such as coronary stent implant).

Ticlopidine works by blocking platelets from sticking together and prevents them from forming harmful clots. It is an antiplatelet drug. It helps keep blood flowing smoothly in your body.

How should I take Ticlopidine?

Take this medication by mouth with food or just after a meal as directed by your doctor, usually twice daily.

The length of treatment is based on your medical condition. If you are taking this medication to prevent clots after a stent implant, it is generally taken with aspirin for up to 30 days unless otherwise directed by your doctor. Consult your doctor for more details.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase. It is important to continue taking this medication even if you feel well. Do not stop taking this medication without consulting your doctor.

How do I store Ticlopidine?

Ticlopidine is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Ticlopidine in the bathroom or the freezer. There may be different brands of Ticlopidine that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Ticlopidine down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Ticlopidine?

Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to similar antiplatelet drugs (thienopyridines such as clopidogrel); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: current or past history of blood or immune disorders (thrombotic thrombocytopenic purpura, aplastic anemia, agranulocytosis, neutropenia), serious/active bleeding (such as bleeding stomach ulcers), bleeding/blood clotting disorders, liver disease, kidney problems.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Your doctor may instruct you to stop ticlopidine for 10 to 14 days before surgery. Follow your doctor’s instructions carefully.

This medication may cause stomach bleeding. Daily use of alcohol while using this medication will increase your risk for stomach bleeding. Limit alcoholic beverages. Ask your doctor or pharmacist about how much alcohol you may safely drink.

Ticlopidine can make you more likely to get infections or may worsen any current infections. Therefore, wash your hands well to prevent the spread of infection. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

While you are taking this medication, it may take longer than usual for bleeding to stop if you have a cut or injury. To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.

Older adults may be at greater risk for bleeding while using this drug.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk, but it may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Ticlopidine during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Ticlopidine. Ticlopidine is pregnancy risk category B according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effect

What side effects can occur from Ticlopidine?

Diarrhea, stomach upset/pain, nausea, and vomiting may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: severe/persistent or bloody diarrhea, vomit that looks like coffee grounds, black stools, blood in the urine, bleeding from gums or nose, unusual weakness/fatigue, easy bruising/bleeding, mental/mood changes, loss of appetite, persistent nausea/vomiting, severe stomach/abdominal pain, signs of kidney problems (such as change in the amount of urine).

This medication may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as fever, chills, persistent sore throat, cough).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Ticlopidine?

Some products that may interact with this drug include: mifepristone, other antiplatelet drugs (such as clopidogrel), cimetidine, antacids.

Other drugs like this medication that affect blood clotting may increase your risk of bleeding. Examples are “blood thinners” (anticoagulants such as enoxaparin, heparin, warfarin). Follow your doctor’s instructions carefully and continue your medications as directed. Tell your doctor right away if you notice unusual bleeding. Consult your doctor or pharmacist for more details.

For certain conditions, you may be instructed by your doctor to take ticlopidine together with aspirin. Follow your doctor’s instructions and continue aspirin as directed. If you are not currently taking aspirin, consult your doctor before starting it for any medical condition. Check the labels on all your medicines because they may contain aspirin or aspirin-like NSAIDs (such as ibuprofen, naproxen) that can increase the risk of bleeding. Ask your pharmacist about the safe use of those products.

Ticlopidine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Ticlopidine?

Ticlopidine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Ticlopidine?

Ticlopidine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Ticlopidine.

What is the dose of Ticlopidine for an adult?

Usual Adult Dose for Cerebral Thrombosis/Embolism

250 mg orally twice a day.

Other Comments

Ticlopidine should be taken with food to minimize gastrointestinal side effects.

In patients receiving an intracoronary stent, following successful stent implantation, ticlopidine therapy may be continued for up to 30 days. However, the results of one study (ATLAST trial) suggest that the frequency of stent thrombosis and other adverse ischemic events remains low even when ticlopidine is discontinued after 2 weeks of therapy. However, the results of another prospective observational cohort study indicate that in patients receiving a drug eluding stent, therapy with either ticlopidine or clopidogrel, in addition to aspirin, should be continued for at least 6 months after stent implantation in order to lower the risk of stent thrombosis. However, the benefit of continuing therapy beyond 6 months is equivocal. Aspirin therapy should be maintained indefinitely.

Ticlopidine may cause life-threatening hematological adverse reactions including neutropenia/agranulocytosis and thrombotic thrombocytopenic purpura (TTP).

It has been suggested that patients receiving ticlopidine should be monitored with liver function tests along with complete blood cell counts.

What is the dose of Ticlopidine for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Ticlopidine available?

Ticlopidine is available in the following dosage forms and strengths:

  • Oral tablet.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Ticlopidine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: May 10, 2018 | Last Modified: May 10, 2018

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