Generic Name: Tiagabine Brand Name(s): Generics only. No brands available.

Uses

What is Tiagabine used for?

Tiagabine is used with other medications to treat certain types of seizures (focal seizures). It works by reducing the spread of seizure activity in the brain. This medication is known as an anticonvulsant or anti-epileptic drug.

When tiagabine has been used for conditions other than epilepsy, serious reactions (including seizures in people who have never had them) have occurred. Talk to your doctor for more details.

How should I take Tiagabine?

Take this medication by mouth with food as directed by your doctor. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. During the first week of treatment, this medication is usually taken once a day. On the following weeks, your doctor may increase your dose to 2 to 4 times daily. Follow your doctor’s instructions carefully.

Tiagabine is not usually used by itself. Do not stop your other anti-seizure medication unless your doctor tells you to do so.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Do not stop taking this medication without consulting your doctor. Some conditions (such as seizures) may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.

If you stop taking this medication for several days, talk with your doctor about how to restart it. You may need to restart with a low dose and slowly increase your dose again.

Tell your doctor if your seizures get worse.

How do I store Tiagabine?

Tiagabine is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Tiagabine in the bathroom or the freezer. There may be different brands of Tiagabine that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Tiagabine down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Tiagabine?

Before taking tiagabine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, mental/mood disorders (such as depression, suicidal thoughts), seizure that doesn’t stop (status epilepticus).

This drug may make you dizzy or drowsy. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

Older adults may be more sensitive to the side effects of this drug, especially dizziness or confusion. These effects can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Tiagabine during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Tiagabine. Tiagabine is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Tiagabine?

Dizziness, drowsiness, stomach pain, diarrhea, nervousness, tiredness, or shaking may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: weakness, trouble concentrating/paying attention, trouble speaking, confusion.

A small number of people who take anticonvulsants for any condition (such as seizure, bipolar disorder, pain) may experience depression, suicidal thoughts/attempts, or other mental/mood problems. Tell your doctor right away if you or your family/caregiver notice any unusual/sudden changes in your mood, thoughts, or behavior including signs of depression, suicidal thoughts/attempts, thoughts about harming yourself.

Get medical help right away if you have a seizure that doesn’t stop (status epilepticus). This is a very rare but very serious side effect.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Tiagabine?

A product that may interact with this drug is: orlistat.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, marijuana, antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), and narcotic pain relievers (such as codeine, hydrocodone).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Tiagabine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Tiagabine?

Tiagabine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Tiagabine?

Tiagabine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Tiagabine.

What is the dose of Tiagabine for an adult?

Usual Adult Dose for Epilepsy

Patients receiving enzyme-inducing AED regimens:

-Initial dose: 4 mg orally once a day; modification of concomitant antiepilepsy drugs is not necessary, unless clinically indicated

-Titration: The total daily dose may be increased by 4 to 8 mg at weekly intervals until clinical response is achieved or, up to 56 mg/day; the total daily dose should be given in divided doses 2 to 4 times a day

-Maximum dose: 56 mg/day (in 2 to 4 divided doses)

Patients not receiving enzyme-inducing AED regimens:

-The estimated plasma concentrations of this drug in non-induced patients is twice that of patients receiving enzyme-inducing AEDs. Lower doses are required and slower titration may be necessary.

Comments:

-This drug should be taken with food.

-Do not use a loading dose.

-Rapid escalation and/or large dose increments should not be used.

-If a scheduled dose is missed, the patient should not make up for the missed dose by increasing the next dose; if several doses are missed, retitration may be required.

-Dosage adjustment may be needed whenever a change in the patient enzyme-inducing status occurs as a result of the addition, discontinuation, or dose change of the enzyme-inducing agent.

Use: For use as adjunctive therapy in the treatment of partial seizures

Usual Adult Dose for Seizures

Patients receiving enzyme-inducing AED regimens:

-Initial dose: 4 mg orally once a day; modification of concomitant antiepilepsy drugs is not necessary, unless clinically indicated

-Titration: The total daily dose may be increased by 4 to 8 mg at weekly intervals until clinical response is achieved or, up to 56 mg/day; the total daily dose should be given in divided doses 2 to 4 times a day

-Maximum dose: 56 mg/day (in 2 to 4 divided doses)

Patients not receiving enzyme-inducing AED regimens:

-The estimated plasma concentrations of this drug in non-induced patients is twice that of patients receiving enzyme-inducing AEDs. Lower doses are required and slower titration may be necessary.

Comments:

-This drug should be taken with food.

-Do not use a loading dose.

-Rapid escalation and/or large dose increments should not be used.

-If a scheduled dose is missed, the patient should not make up for the missed dose by increasing the next dose; if several doses are missed, retitration may be required.

-Dosage adjustment may be needed whenever a change in the patient enzyme-inducing status occurs as a result of the addition, discontinuation, or dose change of the enzyme-inducing agent.

Use: For use as adjunctive therapy in the treatment of partial seizures

Other Comments

Administration advice:

-This drug should be taken with food.

-Modification of concomitant antiepileptic drugs is not necessary, unless it is indicated clinically.

Patient advice:

-Patients should be informed of the availability of a Medication Guide, and they should be instructed to read it prior to taking this drug.

What is the dose of Tiagabine for a child?

Usual Pediatric Dose for Epilepsy

Less than 12 years: No dosing guidelines established.

Patients 12 years or older receiving enzyme-inducing AED regimens:

-Initial dose: 4 mg orally once a day; modification of concomitant antiepilepsy drugs is not necessary, unless clinically indicated

-Titration: The total daily dose may be increased by 4 mg at the beginning of Week 2; thereafter, the total daily dose may be increased by 4 to 8 mg at weekly intervals until clinical response is achieved or up to 32 mg/day (in divided doses 2 to 4 times a day); doses above 32 mg/day have been tolerated in a small number of adolescent patients for a relatively short duration

Patients 12 years or older not receiving enzyme-inducing AED regimens:

-The estimated plasma concentrations of this drug in non-induced patients is twice that of patients receiving enzyme-inducing AEDs. Lower doses are required and slower titration may be necessary.

Comments:

-This drug should be taken with food.

-Do not use a loading dose.

-Rapid escalation and/or large dose increments of should not be used.

-If a scheduled dose is missed, the patient should not make up for the missed dose by increasing the next dose; if several doses are missed, retitration may be required.

-Dosage adjustment may be needed whenever a change in the patient enzyme-inducing status occurs as a result of the addition, discontinuation, or dose change of the enzyme-inducing agent.

Use: For use as adjunctive therapy in children 12 years and older in the treatment of partial seizures

Usual Pediatric Dose for Seizures

Less than 12 years: No dosing guidelines established.

Patients 12 years or older receiving enzyme-inducing AED regimens:

-Initial dose: 4 mg orally once a day; modification of concomitant antiepilepsy drugs is not necessary, unless clinically indicated

-Titration: The total daily dose may be increased by 4 mg at the beginning of Week 2; thereafter, the total daily dose may be increased by 4 to 8 mg at weekly intervals until clinical response is achieved or up to 32 mg/day (in divided doses 2 to 4 times a day); doses above 32 mg/day have been tolerated in a small number of adolescent patients for a relatively short duration

Patients 12 years or older not receiving enzyme-inducing AED regimens:

-The estimated plasma concentrations of this drug in non-induced patients is twice that of patients receiving enzyme-inducing AEDs. Lower doses are required and slower titration may be necessary.

Comments:

-This drug should be taken with food.

-Do not use a loading dose.

-Rapid escalation and/or large dose increments of should not be used.

-If a scheduled dose is missed, the patient should not make up for the missed dose by increasing the next dose; if several doses are missed, retitration may be required.

-Dosage adjustment may be needed whenever a change in the patient enzyme-inducing status occurs as a result of the addition, discontinuation, or dose change of the enzyme-inducing agent.

Use: For use as adjunctive therapy in children 12 years and older in the treatment of partial seizures

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Reduce the dose and/or prolong the dose interval.

Dose Adjustments

-Consider dosage adjustment when a change in enzyme-inducing status occurs due to the addition, discontinuation, or dose change of the enzyme-inducing agent.

-If multiple doses are missed, evaluate if retitration is clinically indicated.

How is Tiagabine available?

Tiagabine is available in the following dosage forms and strengths:

  • Oral tablet.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Tiagabine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

 

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: May 10, 2018 | Last Modified: May 10, 2018

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