Thrombate III/Antithrombin III

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Generic Name: Thrombate III/Antithrombin III Brand Name(s): Thrombate III/Antithrombin III.

Uses

What is thrombate III/ antithrombin III used for?

Thrombate III/ antithrombin III is commonly used for patients with hereditary antithrombin deficiency for:

  • Treatment and prevention of thromboembolism
  • Prevention of peri-operative and peri-partum thromboembolism

How should I take thrombate III/ antithrombin III?

This drug is taken by intravenous after reconstitution only.

How do I store thrombate III/ antithrombin III?

Thrombate III/ antithrombin III is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store thrombate III/ antithrombin III in the bathroom or the freezer. There may be different brands of thrombate III/ antithrombin III that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush thrombate III/ antithrombin III down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using thrombate III/ antithrombin III?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of thrombate III/ antithrombin III or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Because thrombate III/ antithrombin III is made from human blood, it may carry a risk of transmitting infectious agents, e.g., viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent.

There is also the possibility that unknown infectious agents may be present in the product. The risk that the product will transmit viruses has been reduced by screening plasma donors for prior exposure to certain viruses, by testing for the presence of certain current virus infections, and by inactivating and removing certain viruses during manufacture. Despite these measures, this product may still potentially transmit diseases.

Hypersensitivity reactions, including anaphylaxis, are possible. Early signs of hypersensitivity reactions, which can progress to anaphylaxis, may include angioedema, chest tightness, hypotension, rash, nausea, vomiting, paresthesia, restlessness, wheezing and dyspnea. If hypersensitivity symptoms occur, discontinue use of the product immediately and administer appropriate emergency treatment.

The effect of drugs that use thrombate III/ antithrombin III to exert their anticoagulation may be altered when thrombate III/ antithrombin III is added or withdrawn. Regularly perform coagulation tests suitable for the anticoagulant used (e.g., aPTT and anti-Factor Xa activity) to avoid excessive or insufficient anticoagulation. Additionally, monitor the patients for the occurrence of bleeding or thrombosis.

Measure functional levels of AT in plasma by amidolytic assays using chromogenic substrates or by clotting assays. Do not use immunoassays because they do not detect all hereditary AT deficiencies.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using thrombate III/ antithrombin III during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking thrombate III/ antithrombin III.

Side effects

What side effects can occur from thrombate III/ antithrombin III?

The most common adverse reactions were dizziness, chest discomfort, nausea, dysgeusia, and pain (cramps).

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with thrombate III/ antithrombin III?

Thrombate III/ antithrombin III may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

The anticoagulant effect of heparin is enhanced by concurrent treatment with thrombate III/ antithrombin III in patients with hereditary AT deficiency. Thus, in order to avoid bleeding, the dosage of heparin (or low molecular weight heparin) may need to be reduced during treatment with thrombate III/ antithrombin III.

Does food or alcohol interact with thrombate III/ antithrombin III?

Thrombate III/ antithrombin III may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with thrombate III/ antithrombin III?

Thrombate III/ antithrombin III may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using thrombate III/ antithrombin III.

 

What is the dose of thrombate III/ antithrombin III for an adult?

Loading Dose

Target AT Level: 120% of normal

Dose (Units): 120 % – baseline % x body weight (kg) 1.4%

Monitor AT Level

  • baseline
  • 20 minutes (peak) post-injection
  • 12 hours post-injection
  • pre-injection (trough)

Dose Adjustment (adjust as needed)

Target AT Level: 80% to 120% of normal

Dose (Units): Target % – trough % x body weight (kg) 1.4%

Monitor AT Level:

  • 20 minutes (peak) post-injection
  • at least every 12 hours post-injection
  • pre-injection (trough)

Maintenance Dose (approximately every 24 hours, adjust as needed)

Target AT Level: 80% to 120% of normal

Dose (Units): Loading Dose x 0.6

Monitor AT Level: approximately every 24 hours, as needed

What is the dose of thrombate III/ antithrombin III for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is thrombate III/ antithrombin III available?

Thrombate III/ antithrombin III is available in the following dosage forms and strengths:

  • Injection

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of thrombate III/ antithrombin III, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: October 12, 2017 | Last Modified: October 12, 2017

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