Thiothixene

By Medically reviewed by hellodoktor

Generic Name: Thiothixene Brand Name(s): Thiothixene.

Uses

What is Thiothixene used for?

Thiothixene is used to treat certain mental/mood disorders (such as schizophrenia). This medicine helps you to think more clearly, feel less nervous, and take part in everyday life. It can reduce aggression and the desire to hurt yourself/others. It may also help to decrease hallucinations (such as hearing/seeing things that are not there). Thiothixene is a psychiatric medication (antipsychotic-type) that works by helping to restore the balance of certain natural substances (such as dopamine) in the brain.

How should I take Thiothixene?

Take this medication by mouth with or without food, usually 1-3 times daily or as directed by your doctor.

Dosage is based on your age, medical condition, and response to treatment. To reduce your risk of side effects such as drowsiness and shaking (tremor), your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor’s directions carefully.

Take this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time(s) each day.

Although you may notice some medication effects soon after starting, for some conditions it may take 2 to 3 weeks before you get the full benefit of this drug.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Also, you may experience symptoms such as severe confusion and hallucinations. To prevent these symptoms while you are stopping treatment with this drug, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details. Report any new or worsening symptoms right away.

Tell your doctor if your condition does not improve or if it worsens.

How do I store Thiothixene?

Thiothixene is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Thiothixene in the bathroom or the freezer. There may be different brands of Thiothixene that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Thiothixene down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Thiothixene?

Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: blood problems (such as low red/white/platelet blood cell counts), a certain eye condition (glaucoma), heart problems (such as fast/irregular heartbeat, low blood pressure), liver disease, breast cancer, brain disorder/tumor/injury, drug/alcohol/substance abuse, Parkinson’s disease, seizures, a certain severe reaction to other antipsychotic-type medications (neuroleptic malignant syndrome-NMS), slow movement of the gut/intestines (such as chronic constipation, intestinal blockage), difficulty urinating (such as due to prostate problems).

This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana.

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

Before having surgery or imaging procedures (such as certain X-rays, CT scans) requiring the use of contrast dye (such as metrizamide), tell your doctor or dentist that you are using this medication and about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication may make you sweat less, making you more likely to get heat stroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest. Get medical help right away if you have a fever that does not go away, mental/mood changes, headache, or dizziness.

Older adults may be more sensitive to the side effects of this drug, especially dizziness, lightheadedness, drowsiness, confusion, constipation, trouble urinating, extrapyramidal symptoms (EPS), and tardive dyskinesia (TD) (see Side Effects). Dizziness, lightheadedness, drowsiness, and confusion can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. Babies born to mothers who have used this drug during the last 3 months of pregnancy may rarely develop symptoms including muscle stiffness or shakiness, drowsiness, feeding/breathing difficulties, or constant crying. If you notice any of these symptoms in your newborn especially during their first month, tell the doctor right away.

Since untreated mental/mood problems (such as schizophrenia) can be a serious condition, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy.

It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Thiothixene during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Thiothixene. Thiothixene is pregnancy risk category N according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Thiothixene?

Drowsiness, dizziness, lightheadedness, dry mouth, blurred vision, constipation, and trouble sleeping may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Dizziness and lightheadedness can increase the risk of falling. Get up slowly when rising from a sitting or lying position.

This drug may cause muscle/nervous system problems (extrapyramidal symptoms-EPS). Your doctor may prescribe another medication to decrease these side effects. Therefore, tell your doctor right away if you notice any of the following side effects: stiff muscles, severe muscle spasms/cramping (such as twisting neck, arching back, eyes rolling up), restlessness/constant need to move, shaking (tremor), slow/shuffling walk, drooling/trouble swallowing, mask-like expression of the face.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people taking this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: fainting, confusion, depression/suicidal thoughts, difficulty urinating.

This medication may cause a condition known as tardive dyskinesia. In some cases, this condition may be permanent. Tell your doctor right away if you develop any involuntary/repetitive muscle movements such as lip smacking/puckering, tongue thrusting, chewing, or finger/toe movements.

In rare cases, thiothixene may increase your level of a certain chemical made by the body (prolactin). For females, this increase in prolactin may result in unwanted breast milk, missed/stopped periods, or difficulty becoming pregnant. For males, it may result in decreased sexual ability, inability to produce sperm, or enlarged breasts. If you develop any of these symptoms, tell your doctor right away.

Tell your doctor right away if any of these rare but very serious side effects occur: easy bruising/bleeding, signs of infection (such as fever, persistent sore throat), severe stomach/abdominal pain, seizures.

This medication may rarely cause a very serious condition called neuroleptic malignant syndrome (NMS). Get medical help right away if you have any of the following symptoms: fever, muscle stiffness/pain/tenderness/weakness, severe tiredness, severe confusion, sweating, fast/irregular heartbeat, dark urine, signs of kidney problems (such as change in the amount of urine).

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Thiothixene?

Some products that may interact with this drug include: anticholinergic/antispasmodic drugs (such as atropine, dicyclomine, scopolamine), lithium, drugs that increase the amount of dopamine in your body (such as cabergoline, levodopa, pergolide, ropinirole), drugs that lower blood pressure (such as guanethidine, alpha blockers like prazosin).

Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, marijuana, antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, and narcotic pain relievers (such as codeine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Thiothixene may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Thiothixene?

Thiothixene may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Thiothixene?

Thiothixene may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Thiothixene.

What is the dose of Thiothixene for an adult?

Usual Adult Dose for Schizophrenia

Mild Conditions:

-Initial dose: 2 mg orally 3 times a day

-Maintenance dose: 15 mg orally per day

Severe Conditions:

-Initial dose: 5 mg orally 2 times a day

-Maintenance dose: 20 to 30 mg orally per day

-Maximum dose: 60 mg orally per day

Comments:

-Dosing should be individually adjusted depending on the chronicity and severity of symptoms.

-In general, small doses should be used initially and gradually increased to the optimal effective level based on patient response.

-Some patients have been successfully maintained on once-a-day therapy.

Use: Schizophrenia

Dialysis

Data not available; however, peritoneal and hemodialysis are known to be of little value in phenothiazine intoxication.

Other Comments

General:

-This drug has not been evaluated in the management of behavioral complications in patients with mental retardation.

-In the event of overdosage, early gastric lavage is helpful; maintain an open airway since involvement of the extrapyramidal system may produce dysphagia and respiratory difficulty; use the standard measures for managing circulatory shock (IV fluids and/or vasoconstrictors norepinephrine and phenylephrine) if hypotension occurs.

Patient Advice:

-This drug may cause side effects that can affect your ability to perform certain activities; avoid driving and activities such as operating machinery until you know how this drug affects you.

-Do not drink alcohol while taking this drug.

-Avoid unnecessary exposure to sunlight and wear sunblock or sunscreen while taking this drug.

What is the dose of Thiothixene for a child?

Usual Pediatric Dose for Schizophrenia

Age 12 years and older:

Mild Conditions:

-Initial dose: 2 mg orally 3 times a day

-Maintenance dose: 15 mg orally per day

Severe Conditions:

-Initial dose: 5 mg orally 2 times a day

-Maintenance dose: 20 to 30 mg orally per day

-Maximum dose: 60 mg orally per day

Comments:

-Dosing should be individually adjusted depending on the chronicity and severity of symptoms.

-In general, small doses should be used initially and gradually increased to the optimal effective level based on patient response.

-Some patients have been successfully maintained on once-a-day therapy.

Use: Schizophrenia

Precautions

Safety and efficacy have not been established in patients younger than 12 years.

How is Thiothixene available?

Thiothixene is available in the following dosage forms and strengths:

  • Oral capsule,
  • Oral concentrate,
  • Intramuscular powder for injection.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Thiothixene, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: May 10, 2018 | Last Modified: September 12, 2019

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