Teniposide

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Generic Name: Teniposide Brand Name(s): Generics only. No brands available.

Uses

What is Teniposide used for?

Teniposide is used with other anti-cancer drugs to treat leukemia and certain cancers. Teniposide works by slowing or stopping the growth of cancer cells.

How should I take Teniposide?

This medication is given by slow injection into a vein by a health care professional over at least 30 to 60 minutes, usually once or twice a week or as directed by your doctor. This medication may cause low blood tension. Tell your doctor or other health care professional if you feel dizzy. Your injection may need to be stopped or given more slowly.

Dosage is based on your medical condition, body size, and response to treatment. Your doctor will check your blood counts to make sure you can receive your next dose. Be sure to keep all medical/lab appointments.

If this medication accidentally leaks into surrounding tissue, the skin and/or muscle may be severely damaged. Tell your doctor right away if you feel pain or irritation at the injection site.

If this medication touches your skin, immediately wash the area well with soap and water. If this medication gets in your eye, open the eyelids and flush with water, then seek immediate medical attention.

How do I store Teniposide?

Unopened ampules of Teniposide Injection are stable until the date indicated on the package when stored under refrigeration 2° to 8°C (36° to 46°F) in the original package. Freezing does not adversely affect the product. Retain in original package to protect from light.

If you need to store teniposide at home, talk with your doctor, nurse, or pharmacist about how to store it.

There may be different brands of Teniposide that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Teniposide down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Teniposide?

Before using teniposide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as polyoxyethylated castor oil), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Tell your doctor your medical history, especially of: current infections, certain virus illnesses (herpes, chickenpox), liver problems, kidney problems, blood disorders (e.g., anemia, clotting problems), Down syndrome, low blood proteins (hypoalbuminemia).

This drug may make you dizzy or drowsy. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose.

Wash your hands well to prevent the spread of infections. Avoid contact with people who have illnesses that may spread to others (e.g., flu, chickenpox).

To lower your chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.

This product contains alcohol. Caution is advised if you have alcohol dependence or liver disease. Ask your doctor or pharmacist about using this product safely.

This medication may lower sperm count or cause abnormal sperm to form. These effects can possibly cause infertility or birth defects. Consult your doctor for more details.

This drug is not recommended for use during pregnancy. It may harm the unborn baby. If you become pregnant or think you may be pregnant, tell your doctor right away. To avoid pregnancy, both males and females using this drug should use reliable form(s) of birth control (e.g., birth control pills, condoms) during treatment. Consult your doctor for details and to discuss effective forms of birth control.

It is not known whether this medication passes into breast milk. However, it may have undesirable effects on a nursing infant. Therefore, breast-feeding while using this medication is not recommended. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Teniposide during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Teniposide. Teniposide is pregnancy risk category D according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Teniposide?

Nausea, vomiting, diarrhea, drowsiness, and pain/redness at the injection site may occur. Nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting. Eating several small meals, not eating before treatment, or limiting activity may help lessen some of these effects. If these effects persist or worsen, tell your doctor or pharmacist promptly.

Temporary hair loss may occur. Normal hair growth should return after treatment has ended.

Many people using this medication may have serious side effects. However, your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. To lower your risk of serious side effects, your doctor will follow your condition closely and order lab tests.

Pain or sores in the mouth and throat may occur. Brush your teeth gently/carefully, avoid using mouthwash that contains alcohol, and rinse your mouth frequently with cool water mixed with baking soda or salt. It may also be best to eat soft, moist foods.

Tell your doctor right away if you have any serious side effects, including: headache, dizziness/fainting, bloody/black/tarry stool, unusual weakness/tiredness, coughing up blood, severe abdominal pain, slow/shallow/rapid breathing, mental/mood changes (e.g., confusion, difficulty staying awake).

A very serious allergic reaction to this drug is unlikely. However, get medical help right away if you notice any of the following symptoms of a serious allergic reaction: fast/irregular heartbeat, flushing of the face, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, fever/chills.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Teniposide?

Some products that may interact with this drug include: live vaccines (e.g., flu vaccine inhaled through the nose, typhoid/polio vaccine taken by mouth), “blood thinners” (e.g., warfarin, enoxaparin), salicylates/NSAIDs (e.g., aspirin, ibuprofen, naproxen, sodium salicylate), drugs that may interact with alcohol (e.g., disulfiram, metronidazole), methotrexate, sulfonamide antibiotics (e.g., sulfamethizole).

Tell your doctor or pharmacist if you are using other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana, drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Check all prescription and nonprescription medicine labels carefully since many contain pain relievers/fever reducers (NSAIDs such as ibuprofen, naproxen, or aspirin) that can increase your risk of bleeding. Low-dose aspirin should be continued if prescribed by your doctor for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day). Consult your doctor or pharmacist for more details.

Teniposide may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Teniposide?

Teniposide may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Teniposide?

Teniposide may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Teniposide.

What is the dose of Teniposide for an adult?

Usual Adult Dose for Acute Lymphocytic Leukemia

For use in the treatment of patients with refractory childhood acute lymphoblastic leukemia:

Patients failing induction therapy with a cytarabine-containing regimen:

165 mg/m² by slow IV infusion and 300 mg/m² cytarabine IV twice weekly for 8 to 9 doses.

Patients refractory to vincristine/prednisone-containing regimens:

250 mg/m² by slow IV infusion and 1.5 mg/m² vincristine IV weekly for 4 to 8 weeks with 40 mg/m² prednisone orally for 28 days.

Usual Adult Dose for non-Hodgkin’s Lymphoma

30 mg/m2/day for 10 days

or

50 to 100 mg/m2 once a week as a single agent

or

60 to 70 mg/m2/day once a week in combination with other chemotherapeutic agents

What is the dose of Teniposide for a child?

Usual Pediatric Dose for Acute Lymphoblastic Leukemia

In combination with other approved anticancer agents, teniposide is indicated for induction therapy in patients with refractory childhood acute lymphoblastic leukemia in the following regimens:

Patients failing induction therapy with a cytarabine-containing regimen:

165 mg/m² by slow IV infusion and 300 mg/m² cytarabine IV twice weekly for 8 to 9 doses.

or

Patients refractory to vincristine/prednisone-containing regimens:

250 mg/m² by slow IV infusion and 1.5 mg/m² vincristine IV weekly for 4 to 8 weeks with 40 mg/m² prednisone orally for 28 days.

or

165 mg/m2 by slow IV infusion on days 1 and 2 of weeks 3, 13, and 23

How is Teniposide available?

Teniposide is available in the following dosage forms and strengths:

  • Intravenous solution.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Teniposide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: June 2, 2018 | Last Modified: June 2, 2018

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