Tamsulosin + Dutasteride

By Medically reviewed by hellodoktor

Generic Name: Tamsulosin + Dutasteride Brand Name(s): Tamsulosin + Dutasteride.

Uses

What is Tamsulosin + Dutasteride used for?

Tamsulosin + Dutasteride used in men to treat the symptoms of an enlarged prostate (benign prostatic hyperplasia-BPH). Dutasteride works by reducing the size of the enlarged prostate. Tamsulosin is known as an alpha-blocker and works by relaxing muscles in the bladder and prostate. This product helps to relieve symptoms of BPH such as difficulty in beginning the flow of urine, weak stream, and the need to urinate frequently or urgently (including during the middle of the night).

Dutasteride is not approved for prevention of prostate cancer. It may slightly increase the risk of developing a very serious form of prostate cancer. Talk to your doctor about the benefits and risks.

This medication should not be used by women or children.

How should I take Tamsulosin + Dutasteride?

Take this medication by mouth as directed by your doctor, usually once daily, 30 minutes after the same meal each day. Swallow this medication whole. Do not crush, chew, or open the capsules.

This medication may cause a sudden drop in your blood pressure, which could lead to dizziness or fainting. This risk is higher when you first start taking this drug or if you restart treatment after you stop taking it. During these times, avoid situations where you may be injured if you faint.

Take this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time each day.

Since this drug can be absorbed through the skin and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication.

It may take up to 4 weeks to notice an improvement in symptoms. Tell your doctor if your symptoms do not improve after 4 weeks or if they worsen.

How do I store Tamsulosin + Dutasteride?

Tamsulosin + Dutasteride is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Tamsulosin + Dutasteride in the bathroom or the freezer. There may be different brands of Tamsulosin + Dutasteride that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Tamsulosin + Dutasteride down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Tamsulosin + Dutasteride?

Before taking this product, tell your doctor or pharmacist if you are allergic to dutasteride or tamsulosin; or to finasteride; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: low blood pressure, certain eye problems (cataracts, glaucoma).

This drug may make you dizzy or drowsy. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

Before having surgery (including cataract/glaucoma eye surgery), tell your doctor or dentist if you are taking or have ever taken this medication, and about all the other products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially dizziness and low blood pressure when getting up from a sitting or lying position. These side effects can increase the risk of falling.

Do not donate blood while you are taking this medication and for at least 6 months after you stop taking it. This will prevent the possibility of your blood being given to a pregnant woman.

This medication should not be used in women, especially during pregnancy or breast-feeding. It may harm an unborn baby or breast-feeding baby. Consult your doctor for more details.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Tamsulosin + Dutasteride during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Tamsulosin + Dutasteride. Tamsulosin + Dutasteride is pregnancy risk category X according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Tamsulosin + Dutasteride?

Dizziness, lightheadedness, drowsiness, runny/stuffy nose, sexual problems (such as decreased sexual interest/ability, ejaculation problems, decrease in the amount of semen/sperm), testicle pain/swelling, increased breast size, or breast tenderness may occur. Sexual problems have continued in some men even after stopping treatment. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: fainting.

Rarely, males may have a painful or prolonged erection lasting 4 or more hours. If this occurs, stop using this drug and get medical help right away, or permanent problems could occur.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Tamsulosin + Dutasteride?

Some products that may interact with this drug include: other alpha blocker drugs (such as prazosin, terazosin).

If you are also taking a drug to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, tadalafil), your blood pressure may get too low which can lead to dizziness or fainting. Your doctor may need to adjust your medications to minimize this risk.

Other medications can affect the removal of this product from your body, which may affect how this product works. Examples include azole antifungals (such as itraconazole, ketoconazole), boceprevir, clarithromycin, cobicistat, HIV protease inhibitors (such as lopinavir, ritonavir), ribociclib, among others.

Tamsulosin + Dutasteride may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Tamsulosin + Dutasteride?

Tamsulosin + Dutasteride may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Tamsulosin + Dutasteride?

Tamsulosin + Dutasteride may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Tamsulosin + Dutasteride.

What is the dose of Tamsulosin + Dutasteride for an adult?

Usual Adult Dose for Benign Prostatic Hyperplasia

Dutasteride 0.5 mg-Tamsulosin 0.4 mg orally once a day approximately 30 minutes after the same meal each day

Use: Treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate.

Renal Dose Adjustments

CrCl 10 mL/min or more: No adjustment recommended

CrCl less than 10 mL/min: Data not available

Liver Dose Adjustments

Mild to moderate liver dysfunction: No adjustment recommended

Other Comments

Administration advice: This drug should be swallowed whole and not chewed or opened.

General: This drug should not be handled by women who are pregnant or who could become pregnant.

Monitoring:

-Genitourinary: Prostate-specific antigen (PSA) (to interpret serial PSA values, baseline PSA should be established at least 3 months after starting treatment and PSA monitored periodically thereafter)

Patient advice:

-Advise patients starting this drug to avoid situations where syncope could result in injury.

-Advise patients to tell their ophthalmologists that they take or have taken this drug.

-Advise patients regarding the possibility and seriousness of priapism.

-Advise patients to avoid blood donation for at least 6 months after their final dose.

What is the dose of Tamsulosin + Dutasteride for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Tamsulosin + Dutasteride available?

Tamsulosin + Dutasteride is available in the following dosage forms and strengths:

  • Oral capsule.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Tamsulosin + Dutasteride, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: June 1, 2018 | Last Modified: September 12, 2019

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