By Medically reviewed by hellodoktor

Generic Name: Syntometrine Brand Name(s): Syntometrine.


What is Syntometrine® (oxytocin and ergometrine) used for?

Syntometrine® is commonly used for:

How should I take Syntometrine® (oxytocin and ergometrine)?

Your doctor or midwife will decide when and how to treat you with Syntometrine®.

How do I store Syntometrine® (oxytocin and ergometrine)?

Syntometrine® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Syntometrine® in the bathroom or the freezer. There may be different brands of Syntometrine® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Syntometrine® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Syntometrine® (oxytocin and ergometrine)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Syntometrine® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using Syntometrine® during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Syntometrine®.

Side effects

What side effects can occur from Syntometrine® (oxytocin and ergometrine)?

Side effects may occur when using this drug, such as:

  • Nausea and vomiting
  • Abdominal pain
  • Headache
  • Dizziness
  • Skin rashes
  • High blood pressure (hypertension)
  • Chest pain
  • Abnormal heartbeats (arrhythmias)
  • Shortness of breath

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Syntometrine® (oxytocin and ergometrine)?

Syntometrine® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • Azole antifungals, e.g., fluconazole, itraconazole
  • Boceprevir
  • Cimetidine
  • Cobicistat
  • Efavirenz
  • Macrolide antibiotics, e.g., erythromycin, clarithromycin, telithromycin
  • Protease inhibitors for HIV infection, e.g., ritonavir, atazanavir, darunavir
  • Telaprevir
  • Ticagrelor

Does food or alcohol interact with Syntometrine® (oxytocin and ergometrine)?

Syntometrine® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Syntometrine® (oxytocin and ergometrine)?

Syntometrine® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Syntometrine® (oxytocin and ergometrine).

What is the dose of Syntometrine® (oxytocin and ergometrine) for an adult?

To help deliver the placenta, one injection is given into the muscle of your thigh, either as the baby’s shoulder is delivered or immediately after the baby has been delivered.

To help prevent or control bleeding, one injection is given into the muscle of your thigh, either just after the placenta has been delivered or when bleeding occurs.

The injection may occasionally be given into a vein instead of muscle if bleeding is very severe, but this is not usually recommended.

What is the dose of Syntometrine® (oxytocin and ergometrine) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Syntometrine® (oxytocin and ergometrine) available?

Syntometrine®is available in the following dosage forms and strengths:

  • Syntometrine® 500 micrograms/5 iu solution for injection

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Syntometrine®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: June 26, 2017 | Last Modified: September 13, 2019

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