By Medically reviewed by hellodoktor

Generic Name: Sulfinpyrazone Brand Name(s): Generics only. No brands available.


What is Sulfinpyrazone used for?

Sulfinpyrazone is used to prevent gout and gouty arthritis. It will not treat a sudden/severe attack of gout and may make it worse. Gout occurs when your uric acid level gets too high, forming uric acid crystals in the joints that cause pain. Sulfinpyrazone belongs to a class of drugs known as uricosurics. It helps the kidneys to get rid of uric acid, thereby lowering high levels of uric acid and preventing crystals from forming. Lowering uric acid levels may also help your kidneys.

How should I take Sulfinpyrazone?

Take this medication by mouth, usually twice daily or as directed by your doctor. Take it with food, milk, or antacids to reduce stomach upset. To prevent kidney stones, it is best to drink a full glass of water (8 ounces or 240 milliliters) with each dose and at least another 8 glasses a day while taking this drug. If your doctor has directed you to restrict your fluid intake, consult your doctor for further instructions. Your doctor may also instruct you on how to decrease acidity in your urine (e.g., avoid large amounts of ascorbic acid/vitamin C) to prevent kidney stones. Your doctor may direct you to take other medications (e.g., sodium bicarbonate, citrate) to make your urine less acidic.

Dosage is based on your condition and response to treatment. Your doctor may direct you to take a low dose at first, then adjust your dose based on uric acid levels and your gout symptoms. After you have been symptom-free for several months and your uric acid levels are normal, your doctor may lower your dose to the lowest effective dose. Follow your doctor’s directions carefully.

If you are also taking cholestyramine, take sulfinpyrazone at least 1 hour before or 4-6 hours after cholestyramine. Consult your doctor for more details.

Sulfinpyrazone should not be started during a sudden/severe gout attack. Wait until your current attack is over before starting this medication. You may experience an increase in the number of gout attacks for several months after starting this medicine while the body removes extra uric acid. If you have a gout attack while taking sulfinpyrazone, continue taking it along with your medications for gout pain.

Sulfinpyrazone is not a pain reliever. To relieve pain from gout, continue to take your medicines prescribed for pain from gout attacks (e.g., colchicine, ibuprofen, indomethacin) as directed by your doctor.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Tell your doctor if your condition persists or worsens.

How do I store Sulfinpyrazone?

Sulfinpyrazone is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Sulfinpyrazone in the bathroom or the freezer. There may be different brands of Sulfinpyrazone that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Sulfinpyrazone down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Sulfinpyrazone?

Before taking sulfinpyrazone, tell your doctor or pharmacist if you are allergic to it; or to phenylbutazone or other pyrazoles; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: bleeding/inflammation in the stomach or intestines (e.g., active peptic ulcer disease), severe kidney disease, a certain type of kidney stone (urate/uric acid).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding problems (e.g., low platelets, blood clotting problems), low blood counts (e.g., anemia, low white blood cells), cancer of the blood (e.g., leukemia), radiation treatment for cancer, diabetes, kidney disease, history of peptic ulcer disease.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Sulfinpyrazone during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Sulfinpyrazone. Sulfinpyrazone is pregnancy risk category N according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Sulfinpyrazone?

Nausea, heartburn, dizziness, and ringing in the ears may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: lower back pain, swelling of the arms/legs/feet, difficult/painful urination, change in amount/color of urine.

Tell your doctor right away if any of these rare but very serious side effects occur: easy bruising/bleeding, bloody/black/tarry stools, fast/irregular heartbeat, signs of infection (e.g., fever, sore throat), severe stomach/abdominal pain, vomit that looks like coffee grounds, unusual tiredness.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Sulfinpyrazone?

This drug should not be used with the following medications because a very serious interaction may occur: cancer chemotherapy, “clot-busting” drugs/thrombolytics (e.g., streptokinase).

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting sulfinpyrazone.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: “blood thinners” (e.g., warfarin, dipyridamole), nitrofurantoin, NSAIDs (e.g., ibuprofen, indomethacin, naproxen), salicylates (e.g., high-dose aspirin), certain anti-seizure medication (hydantoins such as phenytoin).

Aspirin can prevent this medication from being fully effective. Avoid aspirin and other salicylates while taking this medication. Many nonprescription products contain aspirin. Consult your pharmacist before using nonprescription medicines if you are uncertain whether they contain aspirin. Low-dose aspirin should be continued if prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention (usually at dosages of 81-325 milligrams per day). Ask your doctor or pharmacist for more details.

Sulfinpyrazone may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Sulfinpyrazone?

Sulfinpyrazone may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

Alcohol can decrease this drug’s effectiveness. Limit alcohol while taking this medication.

What health conditions may interact with Sulfinpyrazone?

Sulfinpyrazone may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Sulfinpyrazone.

What is the dose of Sulfinpyrazone for an adult?

Adult Dose for Gout Or Removing Uric Acid From The Body

The starting dose of sulfinpyrazone is usually 100 mg or 200 mg a day (one-half of a 100-mg tablet two times a day, one 100-mg tablet one or two times a day, or one 200-mg capsule or tablet once a day). Then, the dose is usually increased by 100 mg or 200 mg every few days, up to 800 mg a day. Starting with a low dose and increasing the dose gradually helps prevent kidney stones and other side effects. After a while, the dose may be changed again, depending on the amount of uric acid in your blood or urine.

What is the dose of Sulfinpyrazone for a child?

Pediatric Dose for Gout Or Removing Uric Acid From The Body

It is not likely that sulfinpyrazone will be needed to treat gout or remove uric acid from the body in children. However, if a child needs sulfinpyrazone, the dose would have to be determined by the doctor.

How is Sulfinpyrazone available?

Sulfinpyrazone is available in the following dosage forms and strengths:

  • Oral tablet
  • Oral capsule

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Sulfinpyrazone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: June 1, 2018 | Last Modified: September 12, 2019

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