Generic Name: Stamaril Brand Name(s): Generics only. No brands available.

Uses

What is Stamaril® (yellow fever virus) used for?

Stamaril® is commonly used for active immunization against yellow fever in patient who:

  • Travelling to, passing through or living in an endemic area.
  • Travelling to any country that requires an International Certificate of Vaccination for entry (which may or may not depend on the previous itinerary).
  • Handling potentially infectious materials (e.g. laboratory personnel).

How should I take Stamaril® (yellow fever virus)?

It is preferable that the vaccine is injected by the subcutaneous route.

Intramuscular injection may be performed if this is in accordance with applicable official recommendations.

For intramuscular use, the recommended injection sites are the anterolateral aspect of the thigh in children less than 12 months of age, the anterolateral aspect of the thigh (or the deltoid muscle if muscle mass is adequate) in children 12 months through 35 months of age or the deltoid muscle in children from 36 months of age onwards and adults.

How do I store Stamaril® (yellow fever virus)?

Stamaril® is best stored in the refrigerator. To prevent drug damage, do not freeze. There may be different brands of Stamaril® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Stamaril® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Stamaril® (yellow fever virus)?

Before injected, there are some important that you may notice:

  • As with all injectable vaccines, appropriate medical treatment and supervision should always be readily available in case of anaphylaxis or other severe hypersensitivity reaction following administration of the vaccine.
  • Syncope can occur following, or even before, any vaccination as a psychogenic response to the needle injection. Procedures should be in place to prevent injury from faints and manage syncopal reactions.
  • Because intramuscular injection can cause injection site hematoma, Stamaril® should not be given by the intramuscular route to persons with any bleeding disorder, such as hemophilia or thrombocytopenia, or to persons on anticoagulant therapy. The subcutaneous route of administration should be used instead.
  • Stamaril® should be administered only to persons who are/will be at risk of infection with yellow fever virus or who must be vaccinated to comply with international health regulations. Before considering administration of yellow fever vaccine, care should be taken to identify those who might be at increased risk of adverse reactions following vaccination

Also, Stamaril® is contraindicated in some case of:

  • Hypersensitivity to the active substance or to any of the excipients or to eggs or chicken proteins
  • Severe hypersensitivity reactions (g., anaphylaxis) after a previous dose of any yellow fever vaccine
  • Age less than 6 months
  • Immunosuppression, whether congenital, idiopathic or as a result of treatment with systemic steroids (greater than the standard dose of topical or inhaled steroids), radiotherapy or cytotoxic drugs
  • History of thymus dysfunction (including myasthenia gravis,thymoma, thymectomy)
  • Symptomatic HIV infection
  • Asymptomatic HIV infection when accompanied by evidence of impaired immune function
  • Moderate or severe febrile illness or acute illness

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category D, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Stamaril® (yellow fever virus)?

There are some side effects occurring when injected Stamaril®, including:

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Stamaril® (yellow fever virus)?

Stamaril® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, including:

  • Any other vaccine or medicinal product in the same syringe

Does food or alcohol interact with Stamaril® (yellow fever virus)?

Stamaril® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Stamaril® (yellow fever virus)?

Stamaril® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

It must not be administered to persons who are receiving immunosuppressant therapy (e.g., cytotoxic agents, systemic steroids, greater than standard dose of topical or inhaled steroids or other agents).

It can induce false positive results with laboratory and/or diagnostic tests for other flavivirus related diseases such as dengue or Japanese encephalitis.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Stamaril® (yellow fever virus).

What is the dose of Stamaril® (yellow fever virus) for an adult?

Primary vaccination

The vaccine should be given at least 10 days before entering an endemic area since protective immunity may not be achieved until at least this time has elapsed.

For adults, the recommended dose is a single dose of 0.5 ml of the reconstituted vaccine.

For older people, the dose is the same as for adults. However due to a potentially higher risk of yellow fever vaccine-associated severe and potentially fatal disease in persons from 60 years of age, the vaccine should only be given when it is considered that there is a significant and unavoidable risk of acquiring yellow fever infection.

Re-vaccination

The duration of protection following administration of one single 0.5 ml dose of Stamaril® is expected to be at least 10 years and may be life-long.

Re-vaccination with one dose of 0.5 ml may be needed in some individuals who had an insufficient immune response after their primary vaccination. Re-vaccination may also be required, depending on official recommendations of local Health Authorities, as a condition of entry in some countries.

What is the dose of Stamaril® (yellow fever virus) for a child?

Primary vaccination

The vaccine should be given at least 10 days before entering an endemic area since protective immunity may not be achieved until at least this time has elapsed.

For children aged 9 months and older, the recommended dose is a single dose of 0.5 ml of the reconstituted vaccine.

For children from 6 to 9 months of age, vaccination is not recommended, except in specific circumstances and in accordance with available official recommendations, in which case the dose is the same as in children aged 9 months and older.

For children under 6 months of age, vaccination is contraindicated in this case.

Re-vaccination

Re-vaccination with one dose of 0.5 ml may be needed in some individuals who had an insufficient immune response after their primary vaccination. Re-vaccination may also be required, depending on official recommendations of local Health Authorities, as a condition of entry in some countries.

How is Stamaril® (yellow fever virus) available?

Stamaril® is available in the following dosage forms and strengths:

  • 10 vials 10 doses + 10 vials 5 ml (diluent)
  • 1 dose (0.5 ml) contains: Yellow fever virus1 17D-204 strain (live, attenuated), not less than 1000 IU

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Stamaril®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: March 11, 2017 | Last Modified: March 11, 2017

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