Solu-Medrol® (Methylprednisolone)

By Medically reviewed by hellodoktor

Generic Name: Solu-Medrol® (Methylprednisolone) Brand Name(s): Generics only. No brands available.


What is Solu-Medrol® (Methylprednisolone) used for?

Solu-Medrol® is a corticosteroid (cortisone-like medicine or steroid). It is used to treat a number of different conditions, such as inflammation (swelling), severe allergies, adrenal problems, arthritis, asthma, blood or bone marrow problems, eye or vision problems, lupus, skin conditions, kidney problems, ulcerative colitis, and flare-ups of multiple sclerosis.

How should I take Solu-Medrol® (Methylprednisolone)?

For injectable form:

  • A nurse or other trained health professional will give you this medicine. This medicine may be given through a needle placed in one of your veins or as a shot into a muscle.
  • A nurse or other health provider will give you this medicine.
  • Your doctor may give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Precautions & warnings

What should I know before using Solu-Medrol® (Methylprednisolone)?

Before using Solu-Medrol®, tell your doctor if you have:

  • Allergic reaction: to Solu-Medrol®, excipients using for dosage form containing Solu-Medrol®. The information is detailed in the leaflet.
  • Allergic reaction to any other medicines, foods, dyes, preservatives, or animals.
  • Pediatric.
  • Geriatric.
  • Used any other health conditions, drugs that have a risk of interaction with Solu-Medrol®.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Solu-Medrol® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Solu-Medrol®. Solu-Medrol® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk;
  • B=No risk in some studies;
  • C=There may be some risk;
  • D=Positive evidence of risk;
  • X=Contraindicated;
  • N=Unknown.

Side effects

What side effects can occur from Solu-Medrol® (Methylprednisolone)?

As taking others medicines, taking Solu-Medrol® can cause some side effects. Most of them are rarely occurring and do not need any supplementary treatment. However, it is always important for you to consult your doctor if you have any problem after taking this medicine.

Some of the side effects are listed below:

  • Color changes on the skin, dark freckles;
  • Diarrhea;
  • Easy bruising;
  • Increased thirst or urination;
  • Red, pink, purple, or brown flat spots or bumps on your skin;
  • Round, puffy face;
  • Skin looks sunken or indented where the shot was given.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Solu-Medrol® (Methylprednisolone)?

Solu-Medrol® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval, such as:

  • Aminoglutethimide;
  • Amphotericin B;
  • Carbamazepine;
  • Cholestyramine;
  • Cyclosporine;
  • Digoxin;
  • Isoniazid;
  • Ketoconazole;
  • Pancuronium;
  • Phenobarbital;
  • Phenytoin;
  • Rifampin or certain antibiotics (such as clarithromycin, erythromycin);
  • Diuretic or “water pill”;
  • A blood thinner (such as warfarin);
  • Pain or arthritis medicine (NSAIDs such as aspirin, celecoxib, ibuprofen);
  • Insulin or diabetes medicine that you take by mouth (such as glyburide, metformin), or estrogen (including birth control pills and hormone replacement therapy) and vaccines.

Does food or alcohol interact with Solu-Medrol® (Methylprednisolone)?

Solu-Medrol® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Solu-Medrol® (Methylprednisolone)?

Solu-Medrol® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have, such as:

  • Kidney disease;
  • Liver disease;
  • Heart disease;
  • Diabetes;
  • Stomach or bowel problems;
  • Adrenal gland problems (such as Cushing syndrome);
  • Nerve or muscle disease (such as myasthenia gravis);
  • Thyroid problems;
  • A recent heart attack;
  • Chicken pox;
  • Measles exposition;
  • Infection, such as herpes eye infection;
  • Tuberculosis;
  • Threadworm (Strongyloides).


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Solu-Medrol® (methylprednisolone).

How is Solu-Medrol® (Methylprednisolone) available?

Solu-Medrol® is available in the following dosage forms and strengths:

  • Powder for Solution: 500 mg, 1000 mg.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services (115) or go to your nearest emergency room.

What should I do if I miss a dose?

You must use this medicine on a fixed schedule. Call your doctor or pharmacist if you miss a dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: October 7, 2016 | Last Modified: September 13, 2019