Solifenacin

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Generic Name: Solifenacin Brand Name(s): Generics only. No brands available.

Uses

What is Solifenacin used for?

Solifenacin is used to treat an overactive bladder. By relaxing the muscles in the bladder, solifenacin improves your ability to control your urination. It helps to reduce leaking of urine, feelings of needing to urinate right away, and frequent trips to the bathroom. This medication belongs to the class of drugs known as antispasmodics.

How should I take Solifenacin?

Take this medication by mouth with or without food as directed by your doctor, usually once a day. Take it with a full glass of liquid. Swallow this medication whole because the powder in the tablet has a strong bitter taste.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

Tell your doctor if your condition does not improve or if it worsens.

How do I store Solifenacin?

Solifenacin is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Solifenacin in the bathroom or the freezer. There may be different brands of Solifenacin that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Solifenacin down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Solifenacin?

Before using this medication, tell your doctor or pharmacist your medical history, especially of: difficulty urinating (urinary retention), other bladder problems (such as bladder outflow obstruction), stomach/intestinal blockage (gastric retention), personal or family history of glaucoma (angle-closure type), liver disease, bowel disease (such as ulcerative colitis), slowed movement of stomach/intestines, constipation, kidney disease, enlarged prostate, a certain muscle/nerve disease (myasthenia gravis).

This drug may make you drowsy or blur your vision. Alcohol or marijuana can make you more drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication may make you sweat less, making you more likely to get heat stroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest. Get medical help right away if you have a fever that does not go away, mental/mood changes, headache, or dizziness.

Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, constipation, or trouble urinating. Drowsiness and confusion can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Solifenacin during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Solifenacin. Solifenacin is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Solifenacin?

Dry mouth, constipation, drowsiness, stomach upset, blurred vision, dry eyes, headache, or unusual tiredness/weakness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.

To prevent constipation, eat a diet adequate in fiber, drink plenty of water, and exercise. If you become constipated while using this drug, consult your pharmacist for help in selecting a laxative.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: severe stomach/abdominal pain, constipation for 3 or more days, difficulty urinating, signs of kidney infection (such as burning/painful/frequent urination, fever, pink/bloody urine), mental/mood changes (such as confusion, hallucinations).

Get medical help right away if you have any very serious side effects, including: eye pain/swelling/redness, vision changes (such as seeing rainbows around lights at night).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Solifenacin?

Some products that may interact with this drug include: pramlintide, potassium tablets/capsules.

Other medications can affect the removal of solifenacin from your body, which may affect how solifenacin works. Examples include certain azole antifungals (such as itraconazole, ketoconazole), among others.

Solifenacin may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Solifenacin?

Solifenacin may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Solifenacin?

Solifenacin may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Solifenacin.

What is the dose of Solifenacin for an adult?

Usual Adult Dose for Urinary Incontinence

Initial dose: 5 mg orally once daily

Maintenance dose: 5 to 10 mg orally once daily

Comment:

-This drug may be taken with or without food.

Use: For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency

Usual Adult Dose for Urinary Frequency

Initial dose: 5 mg orally once daily

Maintenance dose: 5 to 10 mg orally once daily

Comment:

-This drug may be taken with or without food.

Use: For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency

Renal Dose Adjustments

-Mild to moderate renal impairment (CrCl greater than 30 mL/min): No adjustment recommended

-Severe renal impairment (CrCl less than 30 mL/min): Dosage should not exceed 5 mg once daily

Liver Dose Adjustments

-Milk hepatic impairment (Child-Pugh A): No adjustment recommended

-Moderate hepatic impairment (Child-Pugh B): Dosage should not exceed 5 mg once daily

-Severe hepatic impairment (Child-Pugh C): Not recommended

Dose Adjustments

Patients taking CYP450 3A4 inhibitors (e.g., ketoconazole, ritonavir, nelfinavir, itraconazole): Dosage should not exceed 5 mg once daily

Other Comments

Administration advice:

-This drug should be swallowed whole.

-This drug may be taken with or without food.

What is the dose of Solifenacin for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Solifenacin available?

Solifenacin is available in the following dosage forms and strengths:

  • Oral

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Solifenacin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: April 26, 2018 | Last Modified: April 26, 2018