Generic Name: Seroquel Brand Name(s): Generics only. No brands available.

Uses

What is Seroquel® (quetiapine) used for?

Seroquel® is an antipsychotic medicine. It works by changing the actions of chemicals in the brain.

Seroquel® is used to treat schizophrenia in adults and children who are at least 13 years old. Seroquel® is also used to treat bipolar disorder (manic depression) in adults and children who are at least 10 years old.

Seroquel® is also used together with antidepressant medications to treat major depressive disorder in adults.

How should I take Seroquel® (quetiapine)?

Never take Seroquel® in larger amounts, or for longer than recommended by your doctor. Follow all directions on your prescription label. High doses or long-term use of quetiapine can cause a serious movement disorder that may not be reversible. Symptoms of this disorder include tremors or other uncontrollable muscle movements.

Take this medicine with a full glass of water. You may take Seroquel® with or without food. Do not crush, chew, or break an extended-release tablet. Swallow it whole.

Seroquel® may cause you to have high blood sugar (hyperglycemia). If you are diabetic, check your blood sugar levels on a regular basis while you are taking Seroquel.

You should not stop using Seroquel® suddenly. Stopping suddenly may make your condition worse.

Blood pressure may need to be checked often in a child or teenager taking Seroquel®.

Quetiapine can cause you to have a false positive drug screening test. If you provide a urine sample for drug screening, tell the laboratory staff that you are taking Seroquel®.

How do I store Seroquel® (quetiapine)?

Seroquel® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Seroquel® in the bathroom or the freezer. There may be different brands of Seroquel® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Seroquel® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Seroquel® (quetiapine)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Seroquel® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Seroquel® is not approved for use in psychotic conditions related to dementia. Quetiapine may increase the risk of death in older adults with dementia-related conditions.

Some young people have thoughts about suicide when first taking Seroquel®. Your doctor will need to check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking Seroquel, do not stop taking it without your doctor’s advice.

Never take Seroquel® in larger amounts, or for longer than recommended by your doctor. High doses or long-term use can cause a serious movement disorder that may not be reversible. Symptoms of this disorder include tremors or other uncontrollable muscle movements.

Seroquel® can cause a serious heart problem if you use certain medicines at the same time, including antibiotics, antidepressants, heart rhythm medicine, antipsychotic medicines, and medicines to treat cancer, malaria, HIV or AIDS. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Seroquel®.

Taking Seroquel® with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Seroquel® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Seroquel®. Seroquel® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Seroquel® (quetiapine)?

Common side effects may include:

  • Trouble with movement
  • Dizziness
  • Weakness
  • Increased appetite
  • Weight gain
  • Sore throat
  • Dry mouth
  • Nausea
  • Vomiting
  • Stomach pain
  • Constipation

Call your doctor at once if you have:

  • Twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs
  • Mask-like appearance of the face, trouble swallowing, problems with speech
  • A light-headed feeling, like you might pass out
  • Blurred vision, tunnel vision, eye pain, or seeing halos around lights
  • Severe nervous system reaction – very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, fainting
  • High blood sugar – increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss
  • Low blood cell counts – sudden weakness or ill feeling, fever, chills, cold or flu symptoms, cough, sore throat, red or swollen gums, painful mouth sores, skin sores, trouble breathing

Report any new or worsening symptoms to your doctor, such as mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself, very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, uncontrolled muscle movements, feeling light-headed, blurred vision, eye pain, increased thirst and urination, excessive hunger, fruity breath odor, weakness, nausea and vomiting.

Get emergency medical help if you have signs of an allergic reaction to Seroquel®: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Seroquel® (quetiapine)?

Seroquel® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • Antibiotic or antifungal medicine
  • Antiviral medicine to treat hepatitis or HIV/AIDS
  • Heart or blood pressure medicine
  • Medicine to treat mental illness
  • John’s wort
  • Seizure medicine
  • Tuberculosis medicine

Does food or alcohol interact with Seroquel® (quetiapine)?

Seroquel® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Seroquel® (quetiapine)?

Seroquel® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Health conditions that may interact with this drug are:

  • Liver or kidney disease
  • Heart disease, heart rhythm problems, a history of heart attack or stroke
  • High or low blood pressure
  • A history of low white blood cell (WBC) counts
  • Abnormal thyroid tests or prolactin levels
  • Seizures or epilepsy
  • Cataracts
  • High cholesterol or triglycerides
  • A personal or family history of diabetes
  • Trouble swallowing

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Seroquel® (quetiapine).

What is the dose of Seroquel® (quetiapine) for an adult?

Usual Adult Dose for Schizophrenia:

Immediate-release tablets:

  • Initial Dose: 25 mg orally twice a day.
  • The dosage may be increased in increments of 25 to 50 mg two times a day or three times a day on the second and third days (as tolerated). By the fourth day, a dosage range of 300 mg to 400 mg daily (divided into 2 or 3 doses a day) may be achieved. Additional dosage adjustments (increases or decreases) of 25 to 50 mg twice a day may be made, as needed. However, at least 2 days should pass between the additional dosage adjustments.
  • Efficacy in schizophrenia has been reported with doses ranging from 150 to 750 mg/day. Maximum clinical effect has been reported at 300 mg/day. The safety of doses above 800 mg/day has not been evaluated in clinical trials.

Extended-release tablets:

  • Initial dose: 300 mg orally once daily without food or with a light meal.
  • Maintenance dose: 400 to 800 mg orally once daily depending on response and tolerance.
  • Maximum dose: Doses above 800 mg daily have not been studied.
  • The dosage of the extended-release tablets may be increased in increments of up to 300 mg daily at intervals as short as 1 day.

Usual Adult Dose for Bipolar Disorder:

Immediate-release tablets: (Mania associated with bipolar I disorder as monotherapy or as adjunct therapy to lithium or divalproex)

  • Initial Dose: 50 mg orally twice a day.
  • The dose may be increased to 200 mg orally twice daily on day 4 in increments of up to 50 mg twice daily. Further dosage adjustments up to 800 mg per day by day 6 should be in increments of no greater than 200 mg/day. Data has been reported to indicate that the majority of patients responded between 400 mg per day to 800 mg per day. The safety of doses above 800 mg per day has not been evaluated in clinical trials.

Immediate-release tablets: (Depressive episodes associated with bipolar disorder)

  • Initial dose: 50 mg orally once a day.
  • The dose may be increased to reach 300 mg orally once a day by day 4. Some patients may require a further increase to 600 mg once a day by increasing the daily dose to 400 mg on day 5 and 600 mg on day 8 of treatment. Efficacy was demonstrated in this patient population at both 300 mg and 600 mg per day. However, no additional benefit was observed in patients receiving 600 mg per day as compared to those patients receiving 300 mg per day.

Extended-release tablets: (Depressive Episodes Associated with Bipolar Disorder)

  • Usual dose of Seroquel for Acute Treatment: administer orally once daily in the evening starting with 50 mg per day and increasing doses to reach 300 mg per day by day 4.
  • Recommended Dosing Schedule: Day 1 – 50 mg, Day 2 – 100, mg, Day 3 – 200 mg, & Day 4 – 300 mg.

Bipolar Mania:

  • Usual dose of Seroquel for Acute Monotherapy or Adjunct Therapy (with lithium or divalproex): administer orally once daily in the evening starting with 300 mg on day 1, 600 mg on day 2, and adjust between 400 mg and 800 mg per day thereafter depending on the clinical response and tolerance of the individual patient.

Bipolar Maintenance:

  • Continue treatment at the dosage required to maintain symptom remission.

Usual Adult Dose for Depression:

As adjunctive therapy to antidepressants for use in the treatment of major depressive disorder:

Extended-release tablets:

  • Initial dose: 50 mg orally once daily in the evening.
  • On day 3, the dose can be increased to 150 mg once daily in the evening.
  • Range: 150 mg to 300 mg orally daily. Doses above 300 mg have not been studied.

Usual Geriatric Dose for Schizophrenia:

Immediate-release tablets:

  • Initial Dose: 25 mg orally once a day.
  • The dose may be increased daily in increments of 25 mg/day to 50 mg/day to an effective dose, depending on the clinical response and tolerability of the patient.
  • Efficacy in schizophrenia has been reported with doses ranging from 150 to 750 mg/day. Maximum clinical effect has been reported at 300 mg/day. The safety of doses above 800 mg/day has not been evaluated in clinical trials.

Extended-release tablets:

  • When an effective immediate-release dose has been reached (above 200 mg), the patient may be switched to the extended-release formulation at an equivalent dose.

Usual Geriatric Dose for Bipolar Disorder:

Extended-release tablets:

  • Initial dose: 50 mg/day.
  • The dose can be increased in increments of 50 mg/day depending on the response and tolerance of the individual patient.

What is the dose of Seroquel® (quetiapine) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Seroquel® (quetiapine) available?

Seroquel® is available in the following dosage forms and strengths:

  • Tablet, film coated: quetiapine fumarate 25mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Seroquel®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: July 13, 2017 | Last Modified: July 13, 2017

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