What is Sedacoron® (amiodarone hydrochloride) used for?
Sedacoron® is commonly used for treating ventricular tachycardia or ventricular fibrillation.
Sedacoron® is used only in treating life-threatening heart rhythm disorders. You will receive your first few doses in a hospital setting, where your heart rhythm can be monitored using an electrocardiograph or ECG (sometimes called an EKG).
How should I take Sedacoron® (amiodarone hydrochloride)?
Take amiodarone exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
You may take this medicine with or without food, but take it the same way each time.
It may take up to 2 weeks before your heart rhythm improves. Keep using the medicine as directed even if you feel well.
How do I store Sedacoron® (amiodarone hydrochloride)?
Sedacoron® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Sedacoron® in the bathroom or the freezer. There may be different brands of Sedacoron® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.
You should not flush Sedacoron® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.
Precautions & warnings
What should I know before using Sedacoron® (amiodarone hydrochloride)?
Before using this drug, tell your doctor if:
- You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
- You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
- You have allergy with any of active or inactive ingredients of Sedacoron® or other medications.
- You have any other illnesses, disorders, or medical conditions.
If you have been taking another heart rhythm medicine, you may need to gradually stop taking it when you start using amiodarone. Follow your doctor’s dosing instructions very carefully.
While using amiodarone, you will need frequent medical tests and chest x-rays to check your thyroid, vision, lungs, and liver function. Amiodarone can have long lasting effects on your body. You may need medical tests for several months after you stop using this medicine.
If you need surgery (including laser eye surgery), tell the surgeon ahead of time that you are using amiodarone. You may need to stop using the medicine for a short time.
Amiodarone can cause dangerous side effects on your heart, liver, lungs, or thyroid.
Amiodarone takes a long time to completely clear from your body. You may continue to have side effects after you stop using it.
Is it safe during pregnancy or breastfeeding?
There are no adequate studies in women for determining risk when using Sedacoron® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Sedacoron®. Sedacoron® is pregnancy risk category D, according to the US Food and Drug Administration (FDA).
FDA pregnancy risk category reference below:
- A=No risk
- B=No risk in some studies
- C=There may be some risk
- D=Positive evidence of risk
What side effects can occur from Sedacoron® (amiodarone hydrochloride)?
Common side effects may include:
- Dizziness, vision problems, seeing halos around lights
- Loss of coordination, feeling weak or tired
- Nausea, vomiting, constipation
- Numbness or tingling
- Abnormal liver function tests
Call your doctor at once if you have any of these side effects, even if they occur up to several months after you stop using amiodarone:
- Wheezing, cough, chest pain, coughing up blood, breathing problems that get worse
- A new or a worsening irregular heartbeat pattern (fast, slow, or pounding heartbeats)
- A light-headed feeling, like you might pass out
- Blurred vision, vision loss, headache or pain behind your eyes, sometimes with vomiting
- Liver problems such as nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
- Signs of overactive thyroid such as weight loss, thinning hair, feeling too hot or too cold, increased sweating, irregular menstrual periods, swelling in your neck (goiter)
- Signs of underactive thyroid such as extreme tired feeling, dry skin, joint pain or stiffness, muscle pain or weakness, hoarse voice, feeling more sensitive to cold temperatures, weight gain
Get emergency medical help if you have signs of an allergic reaction to amiodarone: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.
What drugs may interact with Sedacoron® (amiodarone hydrochloride)?
Sedacoron® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.
Does food or alcohol interact with Sedacoron® (amiodarone hydrochloride)?
Sedacoron® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.
What health conditions may interact with Sedacoron® (amiodarone hydrochloride)?
Sedacoron® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.
These health conditions are:
- Asthma or another lung disorder
- Liver disease
- A thyroid disorder
- Vision problems
- High or low blood pressure
- An electrolyte imbalance (such as low levels of potassium or magnesium in your blood)
- A pacemaker or defibrillator implanted in your chest
- Certain serious heart conditions, especially “AV block” (unless you have a pacemaker)
- A history of slow heart beats
- A heart cannot pump blood properly
The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Sedacoron® (amiodarone hydrochloride).
What is the dose of Sedacoron® (amiodarone hydrochloride) for an adult?
Initial dose (IV)
The recommended dose is 1000 mg over the first 24 hours of therapy, delivered by the following infusion regimen: 150 mg over the first 10 minutes (15 mg/min), followed by 360 mg over the next 6 hours (1 mg/min).
Maintenance infusion is 540 mg over the remaining 18 hours (0.5 mg/min).
Initial dose (PO)
Loading doses of 800 to 1600 mg/day are required for 1 to 3 weeks (occasionally longer) until initial therapeutic response occurs.
When adequate arrhythmia control is achieved, or if side effects become prominent, the dose should be reduced to 600 to 800 mg/day for one month and then to the maintenance dose, usually 400 mg/day.
Some patients may require up to 600 mg/day. Amiodarone may be administered as a single daily dose, or in patients with severe gastrointestinal intolerance, as a twice daily dose.
What is the dose of Sedacoron® (amiodarone hydrochloride) for a child?
Less than 1 month
Oral loading dose is 10 to 20 mg/kg/day orally in 2 divided doses for 7 to 10 days. Dosage should then be reduced to 5 to 10 mg/kg/day once daily and continued for 2 to 7 months.
Intravenous loading dose is 5 mg/kg given over 60 minutes.
Note: Bolus infusion rates should generally not exceed 0.25 mg/kg/minute unless clinically indicated; most studies used bolus infusion time of 60 minutes to avoid hypotension; may repeat initial loading dose to a maximum total initial load: 10 mg/kg; do not exceed total daily bolus of 15 mg/kg/day.
Less than 1 year
Initial dose is 600 to 800 mg/1.73 m²/day orally for 4 to 14 days given in 1 to 2 divided doses/day.
Maintenance dose is 200 to 400 mg/1.73 m²/day orally given once a day.
Greater than 1 year
Initial dose is 10 to 15 mg/kg/day orally for 4 to 14 days given in 1 to 2 divided doses/day.
Maintenance dose is 5 to 10 mg/kg/day orally given once a day.
How is Sedacoron® (amiodarone hydrochloride) available?
Sedacoron® is available in the following dosage forms and strengths:
- Injectable; Subcutaneous; Amiodarone Hydrochloride 150 mg
- Injectable; Subcutaneous; Amiodarone Hydrochloride 50 mg / ml
- Tablet; Oral; Amiodarone Hydrochloride 200 mg
What should I do in case of an emergency or overdose?
In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.
What should I do if I miss a dose?
If you miss a dose of Sedacoron®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose
Hello Health Group does not provide medical advice, diagnosis or treatment.
Sedacoron®. http://www.catalog.md/drugs/Sedacoron.html. Accessed December 29, 2016
Amiodaron. https://www.drugs.com/amiodarone.html Accessed December 29, 2016.
Review Date: May 14, 2017 | Last Modified: September 13, 2019