Sandostatin

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Generic Name: Sandostatin Brand Name(s): Generics only. No brands available.

Uses

What is Sandostatin® (octreotide) used for?

Sandostatin® is commonly used for the treatment of severe watery diarrhea and sudden reddening of the face and neck which are caused by certain types of tumors (e.g., carcinoid tumors, vasoactive intestinal peptide tumors). Sandostatin® works by blocking the production of hormones and reduce the loss of body fluids and minerals.

Octreotide is also used to treat acromegaly when the body makes too much of a certain natural substance called growth hormone. Treating acromegaly helps reduce the risk of serious problems such as diabetes and heart disease.

How should I take Sandostatin® (octreotide)?

To take Sandostatin®,

  • Use Sandostatin® exactly as prescribed by your doctor. Do not use this medicine in larger or smaller amounts or for longer than recommended.
  • Sandostatin® is injected under the skin (subcutaneously), or into a vein through an IV (intravenously). You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, IV tubing, and other items used to inject the medicine.
  • Prepare your dose only when you are ready to give yourself an injection. Do not use Sandostatin® if it has changed colors or has particles in it. Call your pharmacist for new medication.
  • Your care provider will show you the best places on your body to inject Sandostatin®. Use a different place each time you give an injection. Do not inject into the same place two times in a row.
  • Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof “sharps” disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets.
  • While using Sandostatin® (octreotide), you may need frequent medical tests.
  • Each single-use ampoule is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.
  • Throw away any Sandostatin® left in the multi-use vial after 14 days of use. Then start a new vial.

How do I store Sandostatin® (octreotide)?

Sandostatin® is best stored in the refrigerator. To prevent drug damage, do not freeze. There may be different brands of Sandostatin® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Sandostatin® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Sandostatin® (octreotide)?

To make sure you can safely use Sandostatin®, tell your doctor if you have:

  • Allergic to octreotide
  • Diabetes
  • Gallbladder disease
  • Heart disease, high blood pressure, or heart rhythm disorder
  • Thyroid problems
  • Pancreatitis
  • Liver disease
  • Kidney disease (or if you are on dialysis)

Is it safe during pregnancy or breastfeeding?

Pregnancy

There are no adequate studies in women for determining risk when using Sandostatin® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Sandostatin®.

Breastfeeding

There are no adequate studies in women for determining infant risk when using medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Side effects

What side effects can occur from Sandostatin® (octreotide)?

Common side effects may include:

  • Diarrhea
  • Constipation
  • Vomiting
  • Upset stomach
  • Bloating
  • Gas
  • Headache
  • Dizziness
  • Pain (when injecting the medicine)

Call your doctor at once if you have:

  • Severe stomach pain or tenderness
  • Severe constipation
  • Slow or uneven heartbeats
  • Severe pain in your upper stomach spreading to your back
  • Nausea
  • Vomiting
  • Fast heart rate
  • High blood sugar
  • Increased thirst
  • Increased urination
  • Hunger
  • Dry mouth
  • Fruity breath odor
  • Drowsiness
  • Dry skin
  • Blurred vision
  • Weight loss
  • Low blood sugar
  • Headache
  • Sweating
  • Confusion
  • Irritability
  • Dizziness
  • Feeling jittery
  • Underactive thyroid
  • Extreme tired feeling
  • Dry skin
  • Joint pain
  • Stiffness
  • Muscle pain
  • Weakness
  • Hoarse voice
  • Feeling more sensitive to cold temperatures
  • Weight gain

Get emergency medical help if you have signs of an allergic reaction to Sandostatin® such as hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Interactions

What drugs may interact with Sandostatin® (octreotide)?

Sandostatin® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Sandostatin® (octreotide)?

Sandostatin® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Sandostatin® (octreotide)?

The presence of other health conditions may affect the use of this medicine. Make sure you tell your doctor if you have any other health conditions, especially:

  • Cholangitis (inflammation or swelling of the bile duct)
  • Congestive heart failure
  • Gallbladder disease
  • Gallstones
  • Heart rhythm problems (e.g., arrhythmia, QT prolongation, slow heartbeat)
  • Pancreatitis (inflammation or swelling of the pancreas)
  • Thyroid problems
  • Vitamin B12 deficiency
  • Diabetes
  • Kidney disease

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Sandostatin® (octreotide).

What is the dose of Sandostatin® (octreotide) for an adult?

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For long-acting injection dosage form:

  • For treatment of acromegaly: At first, 20 milligrams (mg) injected into the gluteal muscle once every 4 weeks for 3 months. Your doctor will adjust your as needed and tolerated.
  • For treatment of severe diarrhea and other symptoms that occur with certain types of intestinal tumors: At first, 20 milligrams (mg) injected into the gluteal muscle once every 4 weeks for 2 months. Your doctor will adjust your as needed and tolerated.

For short-acting injection dosage form:

  • For treatment of acromegaly: 50 micrograms (mcg) injected under the skin or into a vein three times a day. Your doctor will adjust your dose as needed.
  • For treatment of carcinoid tumors: 100 to 600 micrograms (mcg) per day, divided into two or four doses and injected under the skin for the first 2 weeks. Your doctor will adjust your dose as needed. However, the dose is usually not more than 1500 mcg per day.
  • For treatment of severe diarrhea that occurs with certain types of intestinal tumors: 200 to 300 micrograms (mcg) per day, divided into two or four doses and injected under the skin for the first 2 weeks. Your doctor will adjust your dose as needed.

What is the dose of Sandostatin® (octreotide) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Sandostatin® (octreotide) available?

Sandostatin® is available in the following dosage forms and strengths:

  • Sandostatin® 05 mg/ml ampul
  • Sandostatin® 1 mg/ml ampul
  • Sandostatin® 2 mg/ml ampul
  • Sandostatin® 5 mg/ml ampul
  • Sandostatin® 1 mg/ml vial

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Sandostatin®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: December 20, 2016 | Last Modified: January 4, 2017

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