Rosuvastatin

By Medically reviewed by hellodoktor

Generic Name: Rosuvastatin Brand Name(s): Rosuvastatin.

Uses

What is Rosuvastatin used for?

Rosuvastatin is used along with a proper diet to help lower “bad” cholesterol and fats (such as LDL, triglycerides) and raise “good” cholesterol (HDL) in the blood. It belongs to a group of drugs known as “statins.” It works by reducing the amount of cholesterol made by the liver. Lowering “bad” cholesterol and triglycerides and raising “good” cholesterol decreases the risk of heart disease and helps to prevent strokes and heart attacks.

In addition to eating a proper diet (such as a low cholesterol/low-fat diet), other lifestyle changes that may help this medication work better include exercising, losing weight if overweight, and stopping smoking. Talk with your doctor for more details.

How should I take Rosuvastatin?

Take this medication by mouth with or without food as directed by your doctor, usually once daily.

The dosage is based on your medical condition, response to treatment, age, race, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). If you are of Asian descent, your doctor may direct you to start with a lower dose because you may be more sensitive to its effects.

Antacids containing aluminum or magnesium can reduce the absorption of this drug. Therefore, if taking this type of antacid, take it at least 2 hours after this medication.

Take this medication regularly in order to get the most benefit from it. Remember to take it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with high cholesterol or triglycerides do not feel sick.

It is very important to continue to follow your doctor’s advice about diet and exercise. It may take up to 4 weeks before you get the full benefit of this drug.

How do I store Rosuvastatin?

Rosuvastatin is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Rosuvastatin in the bathroom or the freezer. There may be different brands of Rosuvastatin that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Rosuvastatin down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Rosuvastatin?

Before taking rosuvastatin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, alcohol use.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Limit alcoholic beverages. Daily use of alcohol may increase your risk for liver problems, especially when combined with rosuvastatin. Ask your doctor or pharmacist for more information.

Older adults may be more sensitive to the side effects of this drug, especially muscle problems.

This medication must not be used during pregnancy. Rosuvastatin may harm an unborn baby. Therefore, it is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control (such as condoms, birth control pills) while taking this medication. If you become pregnant or think you may be pregnant, tell your doctor right away.

This medication passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Rosuvastatin during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Rosuvastatin. Rosuvastatin is pregnancy risk category X according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Rosuvastatin?

A very small number of people taking rosuvastatin may have mild memory problems or confusion. If these rare effects occur, talk to your doctor.

Rarely, statins may cause or worsen diabetes. Talk to your doctor about the benefits and risks.

Tell your doctor right away if this unlikely but serious side effect occurs: foamy urine.

This drug may rarely cause muscle problems (which can rarely lead to very serious conditions called rhabdomyolysis and autoimmune myopathy). Tell your doctor right away if you develop any of these symptoms during treatment and if these symptoms persist after your doctor stops this drug: muscle pain/tenderness/weakness (especially with fever or unusual tiredness), signs of kidney problems (such as change in the amount of urine).

This medication may rarely cause liver problems. If you notice any of the following rare but serious side effects, tell your doctor right away: yellowing eyes/skin, dark urine, severe stomach/abdominal pain, persistent nausea/vomiting.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Rosuvastatin?

Some products that may interact with this drug include: “blood thinners” (such as warfarin), gemfibrozil.

Other medications can affect the removal of rosuvastatin from your body, which may affect how rosuvastatin works. Examples include ledipasvir, sofosbuvir/velpatasvir/voxilaprevir, among others.

Rosuvastatin may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Rosuvastatin?

Rosuvastatin may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

Do not take any red yeast rice products while you are taking rosuvastatin because some red yeast rice products may also contain a statin called lovastatin. Taking rosuvastatin and red yeast rice products together can increase your risk of serious muscle and liver problems.

What health conditions may interact with Rosuvastatin?

Rosuvastatin may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Rosuvastatin.

What is the dose of Rosuvastatin for an adult?

Usual Adult Dose for Hyperlipidemia

Initial dose: 10 mg to 20 mg orally once a day

Maintenance dose: 5 mg to 40 mg orally once a day

Uses: To be used as an adjunct to diet in the following situations: to slow the progression of atherosclerosis; to reduce elevated total cholesterol (Total-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein B (ApoB), non-high density lipoprotein cholesterol (nonHDL-C), and triglycerides, and to increase HDL-C in primary hyperlipidemia or mixed dyslipidemia; for the treatment of hypertriglyceridemia; for the treatment of primary dysbetalipoproteinemia (Type III Hyperlipoproteinemia)

Usual Adult Dose for Hyperlipoproteinemia Type III (Elevated beta-VLDL + IDL)

Initial dose: 10 mg to 20 mg orally once a day

Maintenance dose: 5 mg to 40 mg orally once a day

Uses: To be used as an adjunct to diet in the following situations: to slow the progression of atherosclerosis; to reduce elevated total cholesterol (Total-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein B (ApoB), non-high density lipoprotein cholesterol (nonHDL-C), and triglycerides, and to increase HDL-C in primary hyperlipidemia or mixed dyslipidemia; for the treatment of hypertriglyceridemia; for the treatment of primary dysbetalipoproteinemia (Type III Hyperlipoproteinemia)

Usual Adult Dose for Hypertriglyceridemia

Initial dose: 10 mg to 20 mg orally once a day

Maintenance dose: 5 mg to 40 mg orally once a day

Uses: To be used as an adjunct to diet in the following situations: to slow the progression of atherosclerosis; to reduce elevated total cholesterol (Total-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein B (ApoB), non-high density lipoprotein cholesterol (nonHDL-C), and triglycerides, and to increase HDL-C in primary hyperlipidemia or mixed dyslipidemia; for the treatment of hypertriglyceridemia; for the treatment of primary dysbetalipoproteinemia (Type III Hyperlipoproteinemia)

Usual Adult Dose for Atherosclerosis

Initial dose: 10 mg to 20 mg orally once a day

Maintenance dose: 5 mg to 40 mg orally once a day

Uses: To be used as an adjunct to diet in the following situations: to slow the progression of atherosclerosis; to reduce elevated total cholesterol (Total-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein B (ApoB), non-high density lipoprotein cholesterol (nonHDL-C), and triglycerides, and to increase HDL-C in primary hyperlipidemia or mixed dyslipidemia; for the treatment of hypertriglyceridemia; for the treatment of primary dysbetalipoproteinemia (Type III Hyperlipoproteinemia)

Usual Adult Dose for Homozygous Familial Hypercholesterolemia

Initial dose: 20 mg orally once a day

Maintenance dose: 5 mg to 40 mg orally once a day

Comments:

-Response to therapy should be estimated from preapheresis LDL-C levels.

Use: For the reduction of LDL-C, Total-C, and ApoB in patients with homozygous familial hypercholesterolemia

Usual Adult Dose for Prevention of Cardiovascular Disease

Initial dose: 10 mg to 20 mg orally once a day

Maintenance dose: 5 mg to 40 mg orally once a day

Use: For individuals without clinically evident coronary heart disease but with an increased risk of cardiovascular disease (CVD) based on age 50 years or older in men and 60 years or older in women, high-sensitivity C-reactive protein test of 2 mg/L or higher, and presence of at least 1 additional CVD risk factor (e.g., hypertension, low HDL-C, smoking, or family history of premature coronary heart disease) to reduce the risk of stroke and myocardial infarction, and reduce the risk of arterial revascularization procedures

Renal Dose Adjustments

Severe renal dysfunction (not on hemodialysis [CrCl less than 30 mL/min]):

-Initial dose: 5 mg orally once a day

-Maximum dose: 10 mg orally once a day

Liver Dose Adjustments

Chronic alcohol liver disease: Caution recommended.

Active liver disease or persistent elevations of hepatic transaminase levels: Contraindicated

Dose Adjustments

Asian Patients:

-Consider an initial dose of 5 mg orally once a day due to increased plasma drug concentrations; the increased systemic exposure should be taken into consideration when treating Asian patients not adequately controlled at doses up to 20 mg/day

Concomitant therapy with cyclosporine:

-Maximum dose: 5 mg orally once a day

Concomitant therapy with gemfibrozil:

-Initial dose: 5 mg orally once a day

-Maximum dose: 10 mg orally once a day

Concomitant therapy with atazanavir and ritonavir, lopinavir and ritonavir or simeprevir:

-Initial dose: 5 mg orally once a day

-Maximum dose: 10 mg orally once a day

Other Comments

Administration advice:

-May be taken orally once a day at any time; swallow whole with or without food

-Do not take 2 doses within 12 hours of each other.

-If antacids are needed, take antacids at least 2 hours after taking this drug.

-This drug should be used in addition to a diet restricted in saturated fat and cholesterol when response to diet and nonpharmacologic interventions alone has been inadequate.

Storage requirements:

-Protect from moisture.

General:

-When initiating therapy and/or switching from another HMG-CoA reductase inhibitor, the appropriate starting dose should be used first and only titrated according to patient’s response and individual goals of therapy.

-Following initiation or upon titration of this drug, lipid levels should be analyzed within 2 to 4 weeks and the dosage adjusted accordingly.

-The 40 mg dose should be reserved for patients who have not achieved their LDL-C goal utilizing the 20 mg dose.

-This drug has not been studied in Fredrickson Type I and V dyslipidemias.

Monitoring:

-Genitourinary: Routine urinalysis testing should be performed

-Hepatic: Measure liver enzymes prior to initiation and if signs/symptoms of liver injury occur

Patient advice:

-Report immediately any unexplained muscle pain, tenderness, or weakness, especially if accompanied by malaise or fever, or if muscle signs/symptoms persist after discontinuing therapy.

-Females of childbearing age should be informed of the consequences of exposure to this drug during pregnancy; ask these patients to report pregnancies as soon as possible.

-Report any signs/symptoms that may be indicative of liver injury (e.g., fatigue, anorexia, right upper abdominal discomfort, dark urine, or jaundice).

What is the dose of Rosuvastatin for a child?

Usual Pediatric Dose for Heterozygous Familial Hypercholesterolemia

8 to less than 10 years: 5 mg to 10 mg orally once a day; safety and efficacy of doses greater than 10 mg/day have not been studied

10 to 17 years: 5 mg to 20 mg orally once a day; safety and efficacy of doses greater than 20 mg/day have not been studied

Comments:

-Dose adjustments should be made at intervals of 4 weeks or more.

-Doses should be based on recommended goal of therapy for each individual patient.

Use: As an adjunct to diet to reduce Total-C, LDL-C, and ApoB levels in patients with heterozygous familial hypercholesterolemia if after an adequate trial of diet therapy the following findings are present: LDL-C greater than 190 mg/dL or greater than 160 mg/dL and there is positive family history of premature cardiovascular disease (CVD) or 2 or more other CVD risk factors

Usual Pediatric Dose for Homozygous Familial Hypercholesterolemia

7 to 17 years: 20 mg orally once a day

Use: As an adjunct to diet to reduce LDL-C, Total-C, nonHDL-C, and ApoB in patients with homozygous familial hypercholesterolemia, either alone or with other lipid-lowering treatments (e.g., LDL apheresis)

Precautions

Safety and efficacy have been not established in patients younger than 7 years.

How is Rosuvastatin available?

Rosuvastatin is available in the following dosage forms and strengths:

  • Oral tablet.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Rosuvastatin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: April 26, 2018 | Last Modified: September 12, 2019

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