Rosampline

By Medically reviewed by hellodoktor

Generic Name: Rosampline Brand Name(s): Rosampline.

Uses

What is rosampline (ampicillin trihydrate) used for?

Ampicillin solution is a penicillin antibiotic. It works by killing sensitive bacteria by interfering with formation of the bacteria’s cell wall while it is growing. This weakens the cell wall and it ruptures, resulting in the death of the bacteria.

Rosampline is commonly used for treating and preventing infections caused by certain types of bacteria.

How should I take rosampline (ampicillin trihydrate)?

Rosampline is usually given as an injection at your doctor’s office, hospital, or clinic. If you use rosampline at home, a health care provider will teach you how to use it. Be sure you understand how to use rosampline. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.

Do not use rosampline if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.

Use rosampline on a regular schedule to get the most benefit from it. Using rosampline at the same time each day will help you remember to use it.

If rosampline is given intravenously (IV) or intramuscularly (IM), it should be given within 1 hour of mixture. After 1 hour, it begins to lose its potency.

To clear up your infection completely, use rosampline for the full course of treatment. Keep using it even if you feel better in a few days.

Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.

How do I store rosampline (ampicillin trihydrate)?

Rosampline is usually handled and stored by a health care provider. If you are using rosampline at home, store rosampline as directed by your pharmacist or health care provider. Keep rosampline out of the reach of children and away from pets.

Precautions & warnings

What should I know before using rosampline (ampicillin trihydrate)?

Before using this drug, tell your doctor if:

  • You are allergic to any ingredient in rosampline or to any other penicillin antibiotic (e.g., amoxicillin).
  • You are pregnant, planning to become pregnant, or are breastfeeding.
  • You are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.
  • You have allergies to medicines, foods, or other substances.
  • You are taking a tetracycline antibiotic (e.g., doxycycline).
  • You have mononucleosis (“mono”).
  • You have recently received or will be receiving live oral typhoid vaccine.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using this medication during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication.

Side effects

What side effects can occur from rosampline (ampicillin trihydrate)?

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

  • Black, “hairy” tongue
  • Inflammation and redness of the tongue
  • Mild diarrhea
  • Nausea
  • Second infection
  • Vomiting

Seek medical attention right away if any of the severe side effects occur:

  • Rash
  • Hives
  • Itching
  • Difficulty breathing
  • Tightness in the chest
  • Swelling of the mouth, face, lips, or tongue
  • Bloody stools
  • Chills
  • Fever
  • Muscle pain
  • Pain, redness, or swelling at the injection site
  • Severe diarrhea
  • Stomach pain/cramps
  • Vaginal irritation or discharge

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with rosampline (ampicillin trihydrate)?

Rosampline may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, including:

  • Tetracyclines (e.g., doxycycline) because they may decrease rosampline ‘s effectiveness.
  • Probenecid because it may increase the risk of rosampline ‘s side effects.
  • Allopurinol because the risk of skin rash may be increased.
  • Anticoagulants (heparin, warfarin) or methotrexate because the risk of their side effects may be increased.
  • Aminoglycosides, birth control pills, or live oral typhoid vaccine because their effectiveness may be decreased.

Does food or alcohol interact with rosampline (ampicillin trihydrate)?

Rosampline may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with rosampline (ampicillin trihydrate)?

Rosampline may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Especially if you have:

  • A stomach infection or diarrhea
  • A severe allergic reaction (e.g., severe rash, hives, difficulty breathing, dizziness) to a cephalosporin (e.g., cephalexin) or other beta-lactam antibiotic (e.g., imipenem).

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using rosampline (ampicillin trihydrate).

What is the dose of rosampline (ampicillin trihydrate) for an adult?

General Dosing Guidelines

The recommended dose is 250-500 mg q6hr, orally.

The recommended dose is 1-2 g q4-6hr, through IV/IM.

Endocarditis Prophylaxis

The recommended dose is 2 g IV/IM (±gentamicin 1.5 mg/kg for GI/GU) within 30 minutes before procedure.

Genitourinary Tract Infections (Excluding Gonorrhea)

The recommended dose is 500 – 2000 mg IV q6hr.

GI Tract Infections

The recommended dose is 500 mg IV q6hr.

Gonorrhea

The recommended dose is 3.5 g IV administered once simultaneously with 1 g of probenecid.

Respiratory Tract Infections

The recommended dose is 250 mg IV q6hr.

Renal Impairment

CrCl <10 mL/min: use q12-16hr.

Other Indications & Uses

Shigella, Salmonella, E. coli, H. influenzae, Proteus mirabilis, N. gonorrhoeae, enterococci infections, N. meningitidis meningitis, gram-pos. staph, strep, pneumococci.

What is the dose of rosampline (ampicillin trihydrate) for a child?

General Dosing Guidelines

The recommended dose is 100-400 mg/kg/day IV/IM divided q6hr.

The recommended dose is 50-100 mg/kg/day PO divided q6hr.

Severe infection: The recommended dose is 200-400 mg/kg/day IV/IM divided q6hr.

Neonates (<28 Days Old)

<7 days old

  • <2 kg: The recommended dose is 50-100 mg/kg/day divided q12hr IV/IM.
  • >2 kg: The recommended dose is 75-150 mg/kg/day divided q8hr IV/IM.

>7 days old

  • <1.2 kg: The recommended dose is 50-100 mg/kg/day divided q12hr IV/IM.
  • 2-2 kg: The recommended dose is 75-150 mg/kg/day divided q8hr IV/IM.
  • >2 kg: The recommended dose is 100-200 mg/kg/day divided q6hr IV/IM.

Endocarditis Prophylaxis

The recommended dose is 50 mg/kg (+/- gentamicin 1.5 mg/kg for GI/GU) IV/IM within 30 minutes before procedure.

Genitourinary Tract Infections

<20 kg: The recommended dose is 50-100 mg/kg/day IV divided q6hr.

>20 kg: The recommended dose is 500 mg IV q6hr.

GI Tract Infections

<20 kg: The recommended dose is 50-100 mg/kg/day IV divided q6hr.

>20 kg: The recommended dose is 500 mg IV q6hr.

Gonorrhea

<20 kg: Safety & efficacy not established.

>20 kg: The recommended dose is 3.5 g IV administered once simultaneously with 1 g of probenecid.

Respiratory Tract Infections

<20 kg: The recommended dose is 50 mg/kg/day IV divided q6-8hr.

>20 kg: The recommended dose is 250 mg IV q6hr.

Cholera

The recommended dose is 50 mg/kg/day PO divided q6hr for 3 days; not to exceed 2 g/day.

Other Information

Potential toxic dose <6 years old: The recommended dose is 300 mg/kg.

Take on empty stomach.

How is rosampline (ampicillin trihydrate) available?

Rosampline is available in the following dosage forms and strengths:

  • Rosampline solution Injection; Ampicillin Trihydrate 1 g

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of rosampline, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: April 14, 2017 | Last Modified: September 13, 2019

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