What is risperidone?

By

Generic Name: Risperidone Brand Name(s): Generics only. No brands available.

Know the basics

What is risperidone used for?

Risperidone is used to treat certain mental/mood disorders (such as schizophrenia, bipolar disorder, irritability associated with autistic disorder). This medication can help you to think clearly and take part in everyday life.

Risperidone belongs to a class of drugs called atypical antipsychotics. It works by helping to restore the balance of certain natural substances in the brain.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This medication may also be used in combination with other medication to treat depression.

How should I take risperidone?

Take this medication by mouth with or without food as directed by your doctor, usually once or twice daily.

This medication comes in a blister pack. Do not remove the tablet from the packaging until you are ready to take it. With dry hands, peel back the foil on the blister pack to carefully remove the tablet. Do not try to push the tablet through the foil because doing so can damage the tablet. Place the tablet on your tongue immediately and allow it to dissolve on your tongue. Do not split or chew the tablet. After the tablet has melted on the tongue, it can be swallowed with or without water.

The dosage is based on your age, medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day. It is important to continue taking this medication as prescribed even if you feel well. Do not stop taking this medication without consulting your doctor.

Tell your doctor if your condition persists or worsens.

How do I store risperidone?

Risperidone is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store risperidone in the bathroom or the freezer. There may be different brands of risperidone that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush risperidone down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Know the precautions & warnings

What should I know before using risperidone?

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of risperidone in children younger than 13 years of age with schizophrenia, in children younger than 10 years of age with bipolar disorder, or in children younger than 5 years of age with autistic disorder. Safety and efficacy have not been established.

Geriatric

Although appropriate studies on the relationship of age to the effects of risperidone have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of risperidone in the elderly. However, elderly patients are more likely to be sensitive to the effects of risperidone, and have age-related liver, kidney, or heart problems, which may require an adjustment in the dose for patients receiving risperidone. This medicine should not be used for behavioral problems in older adults with dementia.

Is it safe to take risperidone during pregnancy or breast-feeding?

There isn’t enough information about the safety of using this medication during pregnancy and breast-feeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication.

Know the side effects

What are the side effects of risperidone?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking risperidone and call your doctor at once if you have a serious side effect such as:

  • fever, stiff muscles, confusion, sweating, fast or uneven heartbeats;
  • restless muscle movements in your eyes, tongue, jaw, or neck;
  • drooling, tremor (uncontrolled shaking);
  • seizure (convulsions);
  • fever, chills, body aches, flu symptoms;
  • nosebleeds;
  • white patches or sores inside your mouth or on your lips;
  • trouble swallowing;
  • feeling like you might pass out; or
  • penis erection that is painful or lasts 4 hours or longer.

Less serious side effects may include:

  • weight gain;
  • feeling hot or cold;
  • headache, dizziness;
  • drowsiness, tired feeling;
  • dry mouth, increased appetite;
  • feeling restless or anxious;
  • sleep problems (insomnia);
  • nausea, vomiting, stomach pain, constipation;
  • cough, sore throat, runny or stuffy nose; or
  • mild skin rash.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Know the interactions

What drugs may interact with risperidone?

Risperidone may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amifampridine
  • Bepridil
  • Cisapride
  • Levomethadyl
  • Mesoridazine
  • Metoclopramide
  • Pimozide
  • Piperaquine
  • Terfenadine
  • Thioridazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acecainide
  • Ajmaline
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Anagrelide
  • Aprindine
  • Aripiprazole
  • Arsenic Trioxide
  • Asenapine
  • Astemizole
  • Azimilide
  • Bretylium
  • Bupropion
  • Buserelin
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Citalopram
  • Clarithromycin
  • Crizotinib
  • Dabrafenib
  • Delamanid
  • Desipramine
  • Deslorelin
  • Dibenzepin
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Doxepin
  • Droperidol
  • Encainide
  • Enflurane
  • Erythromycin
  • Escitalopram
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Foscarnet
  • Gemifloxacin
  • Ginkgo Biloba
  • Gonadorelin
  • Goserelin
  • Halofantrine
  • Haloperidol
  • Histrelin
  • Hydromorphone
  • Hydroquinidine
  • Ibutilide
  • Imipramine
  • Ivabradine
  • Ketoconazole
  • Leuprolide
  • Linezolid
  • Lithium
  • Lorcainide
  • Mefloquine
  • Metronidazole
  • Milnacipran
  • Moxifloxacin
  • Nafarelin
  • Nortriptyline
  • Octreotide
  • Ondansetron
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Sematilide
  • Sertindole
  • Sertraline
  • Sevoflurane
  • Simvastatin
  • Sotalol
  • Spiramycin
  • Sulfamethoxazole
  • Sultopride
  • Tedisamil
  • Telithromycin
  • Tetrabenazine
  • Tramadol
  • Trifluoperazine
  • Trimethoprim
  • Trimipramine
  • Triptorelin
  • Vandetanib
  • Vemurafenib
  • Vinflunine
  • Zotepine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Carbamazepine
  • Cimetidine
  • Fosphenytoin
  • Itraconazole
  • Lamotrigine
  • Levorphanol
  • Methadone
  • Midodrine
  • Paroxetine
  • Phenobarbital
  • Phenytoin
  • Ranitidine
  • Ritonavir
  • Valproic Acid

Does food or alcohol interact with risperidone?

Risperidone may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with risperidone?

Risperidone may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • Aspiration pneumonia, risk or history of or
  • Blood circulation problems or
  • Dehydration or
  • Dementia, such as decreasing mental ability or
  • Difficulty swallowing—May cause side effects to become worse.
  • Breast cancer, prolactin-dependent or
  • Diabetes or
  • Epilepsy or other seizure disorders or
  • Heart or blood vessel problems, including stroke and unusual heartbeats or
  • Hyperglycemia (high blood sugar) or
  • Hyperprolactinemia (high prolactin in the blood) or
  • Parkinson disease—May make these conditions worse.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
  • Phenylketonuria (PKU)—The oral disintegrating tablets may contain aspartame, which can make this condition worse.

Understand the dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of risperidone for an adult?

Usual Adult Dose for Schizophrenia

Oral Formulations:

Initial dose: 2 mg orally per day

Titration dose: May increase in increments of 1 to 2 mg per day at interval of 24 hours or more, as tolerated.

Target dose: 4 to 8 mg orally per day

Maximum dose: 16 mg orally per day

Long-acting IM Injection:

For patients who have never taken oral risperidone, it is recommended to establish tolerability with the oral formulation prior to initiating treatment with long acting injection.

Initial dose: 25 mg IM every 2 weeks

Titration dose: May increase to 37.5 mg or 50 mg if needed; dose titration should occur no more frequently than every 4 weeks as expected drug release starts 3 weeks after injection.

Maximum dose: 50 mg IM every 2 weeks

Usual Adult Dose for Bipolar Disorder

Oral formulations:

Initial dose: 2 to 3 mg orally per day

Titration dose: May increase in increments of 1 mg per day at interval of 24 hours or more, as tolerated.

Effective dose range: 1 to 6 mg orally per day

Maximum dose: 6 mg orally per day

Long-acting IM Injection:

For patients who have never taken oral risperidone, it is recommended to establish tolerability with oral formulation prior to initiating treatment with long acting injection.

Initial dose: 25 mg IM every 2 weeks

Titration dose: May increase to 37.5 mg or 50 mg if needed; dose titration should occur no more frequently than every 4 weeks as expected drug release starts 3 weeks after injection.

Maximum dose: 50 mg IM every 2 weeks

What is the dose of risperidone for a child?

Usual Pediatric Dose for Schizophrenia

13 years or older:

Initial dose: 0.5 mg orally once a day

Titration dose: May increase in increments of 0.5 mg to 1 mg per day at interval of 24 hours or more, as tolerated.

Target dose: 3 mg orally per day

Maximum dose: 6 mg orally per day

Usual Pediatric Dose for Bipolar Disorder

10 years or older:

Initial dose: 0.5 mg orally once a day

Titration dose: May increase in increments of 0.5 mg to 1 mg per day at interval of 24 hours or more, as tolerated.

Target dose: 1 to 2.5 mg orally per day

Maximum dose: 6 mg orally per day

Usual Pediatric Dose for Autism

Ages 5 to 17 years:

Weight greater than 15 kg and less than 20 kg:

Initial dose: 0.25 mg orally once a day

Titration: after a minimum of 4 days, may increase to 0.5 mg per day; maintain this dose for a minimum of 14 days; subsequent dose increases may be made in increments of 0.25 mg at intervals of 2 weeks or more, as tolerated

Recommended dose: 0.5 mg orally per day

Weight 20 kg or greater:

Initial dose: 0.5 mg orally once a day

Titration: After a minimum of 4 days, may increase to 1 mg per day; maintain this dose for a minimum of 14 days; subsequent dose increases in increments of 0.5 mg at intervals of 2 weeks or more, as tolerated.

Recommended dose: 1 mg orally per day

Effective dose range: 0.5 mg to 3 mg orally per day; individualize dose according to response and tolerability.

Maximum dose: 3 mg orally per day

Maintenance dose: Once sufficient clinical response has been achieved and maintained, consider gradually reducing the dose to achieve the optimal balance of safety and efficacy.

How is risperidone available?

Risperidone is available in the following dosage forms and strengths:

Tablet 0.25 mg; 0.5 mg; 1 mg; 2 mg; 3 mg; 4 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

Symptoms of overdose may include:

  • drowsiness
  • fast, pounding, or irregular heartbeat
  • upset stomach
  • blurred vision
  • fainting
  • dizziness
  • seizures

What should I do if I miss a dose?

If you miss a dose of risperidone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: May 30, 2016 | Last Modified: January 4, 2017

Want to live your best life?
Get the Hello Doktor Daily newsletter for health tips, wellness updates and more.
You might also like