By Medically reviewed by hellodoktor

Generic Name: Risordan Brand Name(s): Risordan and Risordan.


What is Risordan® (isosorbide dinitrate) used for?

Risordan® is a nitrate. It works by relaxing the blood vessels in the body, allowing them to widen. This lets more blood flow through the blood vessels, which reduces the work the heart has to do to pump blood. This reduces the oxygen needs of the heart and decreases chest pain.

It is commonly used for preventing symptoms of angina (chest pain) caused by heart disease. Risordan® is used alone or with other medicines.

Risordan® is not intended for the immediate relief of acute attacks of angina. It may also be used for other conditions as determined by your doctor.

How should I take Risordan® (isosorbide dinitrate)?

To take this drug,

  • Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
  • Isosorbide dinitrate is usually taken 2 or 3 times per day. Follow your doctor’s dosing instructions very carefully.
  • If possible, try to rest or stay seated when you take this medicine. Isosorbide dinitrate can cause dizziness or fainting.
  • Do not crush, chew, break, or open an extended-release capsule or tablet. Swallow it whole.
  • If you expect to engage in an activity that may cause angina, take the sublingual tablet about 15 minutes before the activity.
  • If you use the sublingual tablet to treat an angina attack that has already begun, use the medicine at the first sign of chest pain. Place the tablet under your tongue and allow it to dissolve slowly. Do not chew or swallow it.
  • It is important to keep this medicine on hand at all times in case of an angina attack. Get your prescription refilled before you run out of medicine completely.
  • You should not stop using isosorbide dinitrate suddenly if you take this medicine to prevent angina. Stopping suddenly may cause you to have a severe attack of angina.
  • Do not change brands of isosorbide dinitrate without the approval of your doctor.

How do I store Risordan® (isosorbide dinitrate)?

Risordan® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Risordan® in the bathroom or the freezer. There may be different brands of Risordan® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Risordan® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Risordan® (isosorbide dinitrate)?

Before using this drug, tell your doctor if:

  • You are allergic to any ingredient in isosorbide dinitrate.
  • You are pregnant, planning to become pregnant, or are breastfeeding.
  • You are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.
  • You have allergies to medicines, foods, or other substances

While using, you should notice:

  • Seek emergency medical attention if your chest pain gets worse or lasts more than 5 minutes, especially if you have trouble breathing or feel weak, dizzy, or nauseated, or lightheaded.
  • You may have very low blood pressure while taking this medicine. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. Prolonged illness can lead to a serious electrolyte imbalance, making it dangerous for you to use isosorbide dinitrate.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using Risordan® during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Risordan®.

Side effects

What side effects can occur from Risordan® (isosorbide dinitrate)?

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

  • Dizziness
  • Flushing of the face and neck
  • Headache
  • Light-headedness

Seek medical attention right away if any of these severe side effects occur:

  • Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue)
  • Fainting
  • Fast or slow heartbeat
  • Nausea
  • New or worsening chest pain
  • Vomiting

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Risordan® (isosorbide dinitrate)?

Risordan® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, including:

  • Avanafil
  • Riociguat
  • Sildenafil
  • Tadalafil
  • Vardenafil

Does food or alcohol interact with Risordan® (isosorbide dinitrate)?

Risordan® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Risordan® (isosorbide dinitrate)?

Risordan® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Especially if you have:

  • Bleeding in the brain
  • A recent head trauma
  • An overactive thyroid
  • Heart problems (e.g., heart failure, cardiomyopathy, history of heart attack),
  • Anemia (a low red blood cell count)


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Risordan® (isosorbide dinitrate).

What is the dose of Risordan® (isosorbide dinitrate) for an adult?



Immediate release:

  • The initial dose is 5-20 mg 2-3 times/day.
  • The maintenance dose is 10-40 mg 2-3 times/day or 5-80 mg 2-3 times/day.

Sustained release:

40-160 mg/day has been used in clinical trials (a nitrate free interval of at least 18 hours is recommended; however, a clinically efficacious dosage interval has not been clearly established) or 40 mg 1-2 times/day.


Prophylactic use: 2.5-5 mg administered 15 minutes prior to activities which may provoke an anginal episode.

Treatment of acute anginal episode (use only if patient has failed sublingual nitroglycerin): 2.5-5 mg every 5-10 minutes for maximum of 3 doses in 15-30 minutes.

Heart failure

Oral: Immediate release

  • The initial dose is 20 mg 3-4 times per day.
  • The target dose is 160 mg/day in 4 divided doses.

Esophageal spastic disorders

Oral, sublingual:

The immediate release dose is 10-30 mg before meals.

What is the dose of Risordan® (isosorbide dinitrate) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Risordan® (isosorbide dinitrate) available?

Risordan® is available in the following dosage forms and strengths:

  • Injectable; Injection; Isosorbide Dinitrate 1 mg / ml
  • Tablets; Oral; Isosorbide Dinitrate 10 mg
  • Tablets; Oral; Isosorbide Dinitrate 20 mg
  • Tablets; Oral; Isosorbide Dinitrate 5 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Risordan®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Review Date: February 6, 2017 | Last Modified: September 13, 2019

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