Risedronate

By Medically reviewed by hellodoktor

Generic Name: Risedronate Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: C

Uses

What is Risedronate used for?

Risedronate is used to prevent and treat certain types of bone loss (osteoporosis) in adults. Osteoporosis causes bones to become thinner and break more easily. Your chance of developing osteoporosis increases as you age, after menopause, or if you are taking corticosteroid medications (such as prednisone) for long periods of time.

This medication works by slowing bone loss to help maintain strong bones and reduce the risk of broken bones (fractures). Risedronate belongs to a class of medications called bisphosphonates.

How should I take Risedronate?

Take this medication by mouth as directed by your doctor, usually once a day. Take it after getting up for the day and before taking your first food, beverage or other medication. Do not take it at bedtime or while you are still in bed.

Take this medication with a full glass of plain water (180 to 240 milliliters). Do not take it with any other beverage. Swallow the tablet whole. Do not chew or suck on it. Then stay fully upright (sitting, standing or walking) for at least 30 minutes, and do not lie down until after your first food of the day. Wait at least 30 minutes after taking risedronate before you eat or drink anything other than plain water and before taking any other medication by mouth.

Calcium or iron supplements, vitamins with minerals, antacids containing calcium/magnesium/aluminum, dairy products (such as milk, yogurt), and calcium-enriched juice may interfere with absorption of risedronate. Medications such as quinapril, certain forms of didanosine (chewable/dispersible buffered tablets or pediatric oral solution), sucralfate, and bismuth subsalicylate may also interfere with absorption. Do not take these products for at least 30 minutes after taking risedronate.

Use this medication regularly in order to get the most benefit from it. Remember to take it at the same time each morning. Talk to your doctor about the risks and benefits of long-term use of this medication.

How do I store Risedronate?

Risedronate is best stored at room temperature away from direct light and moisture. Keep unused effervescent tablets in the foil blister pack. To prevent drug damage, you should not store Risedronate in the bathroom or the freezer. There may be different brands of Risedronate that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Risedronate down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Risedronate?

Before taking risedronate, tell your doctor or pharmacist if you are allergic to it; or to other bisphosphonates (such as alendronate, etidronate, pamidronate); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: esophagus problems (such as esophageal stricture, achalasia), difficult or painful swallowing, low blood calcium levels (hypocalcemia), inability to sit upright or stand for at least 30 minutes, severe kidney disease, stomach/intestinal disorders (such as ulcers).

Some people taking risedronate may have serious jawbone problems. Your doctor should check your mouth before you start this medication. Tell your dentist that you are taking this medication before you have any dental work done. To help prevent jawbone problems, have regular dental exams and learn how to keep your teeth and gums healthy. If you have jaw pain, tell your doctor and dentist right away.

Before having any surgery (especially dental procedures), tell your doctor and dentist about this medication and all other products you use (including prescription drugs, nonprescription drugs, and herbal products). Your doctor or dentist may tell you to stop taking risedronate before your surgery. Ask for specific instructions about stopping or starting this medication.

Caution is advised if you are pregnant or planning to become pregnant in the future. This medication may stay in your body for many years. Its effects on an unborn baby are not known. Discuss the risks and benefits with your doctor before starting treatment with risedronate.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Risedronate during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Risedronate. Risedronate is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Risedronate?

Upset stomach may occur. If this effect persists or worsens, tell your doctor or pharmacist promptly.

Tell your doctor right away if you have any serious side effects, including: increased or severe bone/joint/muscle pain, new or unusual hip/thigh/groin pain, jaw pain, eye/vision problems.

This medication may rarely cause irritation and ulcers in your stomach or esophagus. Get medical help right away if any of these serious side effects occur: new/severe/worsening heartburn, chest pain, difficult or painful swallowing, severe stomach/abdominal pain, black/tarry stools, vomit that looks like coffee grounds.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Risedronate?

This medication may affect the results of certain lab tests (bone-imaging agents). Be sure to tell your doctor or laboratory personnel that you are taking this medication.

Risedronate may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Risedronate?

Risedronate may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Risedronate?

Risedronate may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Risedronate.

What is the dose of Risedronate for an adult?

Usual Adult Dose for Osteoporosis

Treatment of Postmenopausal Osteoporosis:

Immediate release:

-5 mg orally once a day or

-35 mg orally once a week or

-75 mg orally on two consecutive days for a total of two tablets each month or

-150 mg orally once a month

Delayed release:

-35 mg orally once a week

Treatment to Increase Bone Mass in Men with Osteoporosis:

Immediate release:

-35 mg orally once a week

Treatment of Glucocorticoid-Induced Osteoporosis:

Immediate release:

-5 mg orally once a day

Uses:

-Treatment to reduce the incidence of vertebral fractures and composite endpoint of nonvertebral osteoporosis-related fractures in postmenopausal women

-Treatment to increase bone mass in men with osteoporosis

-Treatment of glucocorticoid-induced osteoporosis in men and women who are either initiating or continuing systemic glucocorticoid treatment (daily dosage of greater than or equal to 7.5 mg of prednisone or equivalent) for chronic diseases

Usual Adult Dose for Prevention of Osteoporosis

Prevention of Postmenopausal Osteoporosis:

-5 mg orally once a day or

-35 mg orally once a week or

-75 mg orally on two consecutive days for a total of two tablets each month or

-150 mg orally once a month

Prevention of Glucocorticoid-Induced Osteoporosis:

-5 mg orally once a week

Uses:

-Prevention of osteoporosis in postmenopausal women

-Prevention of glucocorticoid-induced osteoporosis in men and women who are either initiating or continuing systemic glucocorticoid treatment (daily dosage of greater than or equal to 7.5 mg of prednisone or equivalent) for chronic diseases

Usual Adult Dose for Paget’s Disease

-30 mg orally once a day for 2 months

Use: Treatment of Paget’s disease of bone in men and women

Renal Dose Adjustments

Mild to moderate renal dysfunction (CrCl 30 mL/min or more): No adjustment recommended.

Severe renal dysfunction (CrCl less than 30 mL/min): Not recommended.

Liver Dose Adjustments

No adjustment recommended.

What is the dose of Risedronate for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Risedronate available?

Risedronate is available in the following dosage forms and strengths:

  • Oral tablet,
  • Oral delayed release tablet.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Risedronate, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: November 13, 2018 | Last Modified: September 12, 2019

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