Generic Name: Rilonacept Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: C

Uses

What is Rilonacept used for?

Rilonacept is used to treat a certain group of inherited disorders called cryopyrin-associated periodic syndromes (CAPS), including familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Rilonacept works by blocking a certain natural protein in your body (interleukin-1) that may worsen the symptoms of CAPS. Rilonacept does not cure CAPS, but it can help lessen the symptoms, including rash, joint pain, fever, and tiredness.

How should I take Rilonacept?

Inject this medication under the skin, usually once weekly or as directed by your doctor. Dosage is based on your age, weight, medical condition, and response to treatment.

Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.

Before injecting each dose, clean the injection site with rubbing alcohol. It is important to change the location of the injection site each time to avoid problem areas under the skin. Do not inject into skin that is tender, red, or hard.

Tell your doctor if your condition does not improve or if it worsens.

How do I store Rilonacept?

Rilonacept is best stored in the refrigerator. To prevent drug damage, do not freeze. There may be different brands of Rilonacept that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Rilonacept down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Rilonacept?

Before using rilonacept, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (e.g., asthma), cancer, cuts or open sores, diabetes, immune system problems (e.g., HIV infection), current/recent/returning infection (including hepatitis and tuberculosis).

Rilonacept can make you more likely to get infections or may worsen any current infections. Therefore, do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose. Also avoid contact with people who have infections that may spread to others (e.g., chickenpox, flu). Wash your hands well to prevent the spread of infections.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Rilonacept during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Rilonacept. Rilonacept is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Rilonacept?

Bruising, itching, pain, redness, swelling, or hardening of the skin at the injection site may occur. Injection site reactions usually go away after 1 or 2 days. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

This medication can affect your immune system. It can lower your body’s ability to fight an infection. You may be more likely to get serious infections, such as pneumonia, bone/joint infections, skin infections, or sinusitis. It may also be harder to fight an infection you already have. Tell your doctor promptly if you develop any signs of an infection, such as worsening redness/swelling/tenderness at the injection site after 2 days, fever/chills, or cold/flu symptoms. This medication can affect the amount of cholesterol and other fats (lipids) in your blood. Your doctor may periodically order laboratory tests to monitor this side effect and prescribe treatment if needed.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Rilonacept?

Some products that may interact with this drug include: anti-cancer drugs, corticosteroids, live vaccines (e.g., polio vaccine taken by mouth, flu vaccine inhaled through the nose), drugs that block tumor necrosis factor-TNF (e.g., adalimumab, etanercept, infliximab), other drugs that block interleukin-1 (e.g., anakinra).

Rilonacept may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Rilonacept?

Rilonacept may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Rilonacept?

Rilonacept may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Rilonacept.

What is the dose of Rilonacept for an adult?

Usual Adult Dose for Familial Cold Autoinflammatory Syndrome

Loading dose: 320 mg delivered as two, 2 mL, subcutaneous injections of 160 mg each given on the same day at two different sites.

Dosing should be continued with a once-weekly injection of 160 mg administered as a single, 2-mL, subcutaneous injection.

Rilonacept should not be given more often than once weekly.

Usual Adult Dose for Muckle Wells Snydrome

Loading dose: 320 mg delivered as two, 2 mL, subcutaneous injections of 160 mg each given on the same day at two different sites.

Dosing should be continued with a once-weekly injection of 160 mg administered as a single, 2-mL, subcutaneous injection.

Rilonacept should not be given more often than once weekly.

Dose Adjustments

Dosage modification is not required based on advanced age or gender.

Precautions

Sites for subcutaneous injection, such as the abdomen, thigh, or upper arm, should be rotated. Injections should never be made at sites that are bruised, red, tender, or hard.

What is the dose of Rilonacept for a child?

Usual Pediatric Dose for Familial Cold Autoinflammatory Syndrome

Greater then or equal to 12 years of age:

Loading dose: 4.4 mg/kg, up to a maximum of 320 mg, delivered as one or two subcutaneous injections with a maximum single-injection volume of 2 mL. If the initial dose is given as two injections, they should be given on the same day at two different sites.

Dosing should be continued with a once-weekly injection of 2.2 mg/kg, up to a maximum of 160 mg, administered as a single subcutaneous injection, up to 2 mL.

Rilonacept should not be given more often than once weekly.

Usual Pediatric Dose for Muckle Wells Snydrome

Greater then or equal to 12 years of age:

Loading dose: 4.4 mg/kg, up to a maximum of 320 mg, delivered as one or two subcutaneous injections with a maximum single-injection volume of 2 mL. If the initial dose is given as two injections, they should be given on the same day at two different sites.

Dosing should be continued with a once-weekly injection of 2.2 mg/kg, up to a maximum of 160 mg, administered as a single subcutaneous injection, up to 2 mL.

Rilonacept should not be given more often than once weekly.

How is Rilonacept available?

Rilonacept is available in the following dosage forms and strengths:

  • Subcutaneous powder for injection.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Rilonacept, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

 

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: November 20, 2018 | Last Modified: November 20, 2018

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