Reserpine

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Generic Name: Reserpine Brand Name(s): Generics only. No brands available.

Uses

What is Reserpine used for?

Reserpine is used with or without other medications to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. It works by decreasing certain substances in the body (such as norepinephrine). This causes the blood vessels to relax so that blood can flow more easily and also slows the heart rate. These effects help to lower blood pressure.

How should I take Reserpine?

Take this medication by mouth with or without food, usually 1 to 2 times daily or as directed by your doctor.

The dosage is based on your medical condition and response to treatment. Do not increase your dose or take this medication more often than prescribed. The risk of serious side effects may be increased.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

It may take several weeks before you get the full benefit of this medication. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

Tell your doctor if your condition does not improve or if it worsens (for example, your routine blood pressure readings remain high or increase).

How do I store Reserpine?

Reserpine is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Reserpine in the bathroom or the freezer. There may be different brands of Reserpine that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Reserpine down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Reserpine?

Before taking reserpine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This drug may make you dizzy or drowsy. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Older adults may be more sensitive to the side effects of this drug, especially dizziness.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk and may have undesirable effects on a nursing infant. Discuss the risks and benefits with your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Reserpine during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Reserpine. Reserpine is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Reserpine?

Drowsiness, dizziness, tiredness, nausea, vomiting, diarrhea, slow heartbeat, and stuffy nose may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: severe stomach/abdominal pain, black stools, fainting, severe dizziness, shortness of breath, swelling ankles/feet, unexplained/sudden weight gain, enlarged breasts (in males), unusual breast discharge (in females).

Tell your doctor right away if any of these rare but very serious side effects occur: very slow/fast/irregular heartbeat, unusual bleeding/bruising, unusual/uncontrolled movements (such as tremor), muscle stiffness.

This medication has caused depression. Depression may persist for several months after stopping the drug. Tell your doctor right away if you develop any signs of depression, including mental/mood changes (such as persistent/severe sadness, thoughts of suicide), trouble sleeping, loss of appetite, decreased sexual interest/ability.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Reserpine?

Some products that may interact with this drug are: deutetrabenazine, tetrabenazine, MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine).

Tell your doctor or pharmacist if you are taking other products that cause drowsiness, including alcohol, marijuana, antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, and narcotic pain relievers (such as codeine).

Check the labels on all your medicines (such as cough-and-cold products, diet aids, nonsteroidal anti-inflammatory drugs-NSAIDs such as ibuprofen for pain/fever reduction) because they may contain ingredients that cause drowsiness or could increase your blood pressure or heart rate. Ask your pharmacist about using those products safely.

This medication may interfere with certain urine laboratory tests (including 17-OHCS and 17-ketosteroids test), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Reserpine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Reserpine?

Reserpine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Reserpine?

Reserpine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: current or previous depression (especially with suicidal thoughts/attempts), current stomach/intestinal ulcer, a certain bowel disease (ulcerative colitis), current shock treatments (electroconvulsive therapy-ECT).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of stomach/intestinal ulcer, gallbladder disease (gallstones), liver disease.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Reserpine.

What is the dose of Reserpine for an adult?

Usual Adult Dose for Hypertension

Initial dose: 0.5 mg orally once a day for 1 to 2 weeks.

Maintenance dose: 0.1 to 0.25 mg orally once a day.

Usual Adult Dose for Schizophrenia

Initial dose: 0.5 mg orally once a day, but may range from 0.1 to 1 mg.

Maintenance dose: Adjust dose upward or downward according to patient response.

Usual Adult Dose for Hyperthyroidism

The value of orally administered reserpine during thyrotoxic crisis is not known.

Limited data in which seven patients with thyrotoxic crisis received reserpine 1 to 5 mg intramuscularly, then 0.07 to 0.3 mg per kg in the first 24 hours reveal significant, dose-related improvement in symptoms within four to eight hours of drug administration.

Renal Dose Adjustments

The elimination half-life of reserpine may be significantly increased in patients with renal insufficiency, therefore reserpine is not recommended in patients with renal dysfunction.

Dose Adjustments

Full antihypertensive effects may take as long as 3 weeks to occur.

Precautions

Use higher doses cautiously because occurrence of serious mental depression and other side effects may increase considerably.

Dialysis

Reserpine is not dialyzable.

What is the dose of Reserpine for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Reserpine available?

Reserpine is available in the following dosage forms and strengths:

  • Oral tablet.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Reserpine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: April 21, 2018 | Last Modified: April 21, 2018

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