By Medically reviewed by hellodoktor

Generic Name: Reglan Brand Name(s): Generics only. No brands available.


What is Reglan® (metoclopramide) used for?

Reglan® increases muscle contractions in the upper digestive tract. This speeds up the rate at which the stomach empties into the intestines.

Reglan® is used short-term to treat heartburn caused by gastroesophageal reflux in people who have used other medications without relief of symptoms.

Reglan® may also be used for purposes not listed in this medication guide.

How should I take Reglan® (metoclopramide)?

Take Reglan® exactly as prescribed by your doctor. Reglan® is usually taken for only 4 to 12 weeks. Follow the directions on your prescription label.

Never take Reglan® in larger amounts than recommended, or for longer than 12 weeks.

High doses or long-term use of Reglan® can cause a serious movement disorder that may not be reversible. Symptoms of this disorder include uncontrollable muscle movements of your lips, tongue, eyes, face, arms, or legs. The longer you take Reglan®, the more likely you are to develop a serious movement disorder. The risk of this side effect is higher in women, diabetics, and older adults.

Take Reglan® 30 minutes before eating. Reglan® is usually taken before meals and at bedtime. Your doctor may want you to take the medication as needed only with meals that usually cause heartburn. Follow your doctor’s instructions.

Measure the liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Do not take two different forms of Reglan® (such as tablets and oral syrup) at the same time.

How do I store Reglan® (metoclopramide)?

Reglan® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Reglan® in the bathroom or the freezer. There may be different brands of Reglan® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Reglan® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Reglan® (metoclopramide)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Reglan® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

You should not take Reglan® if you have:

  • Bleeding or blockage in your stomach or intestines
  • A perforation (hole) in your stomach or intestines
  • Epilepsy or other seizure disorder
  • An adrenal gland tumor (pheochromocytoma)

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Reglan® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Reglan®. Reglan® is pregnancy risk category B, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Reglan® (metoclopramide)?

Get emergency medical help if you have any of these signs of an allergic reaction to Reglan®: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking Reglan® and call your doctor at once if you have any of these signs of a serious movement disorder, which may occur within the first 2 days of treatment:

  • Tremors or shaking in your arms or legs
  • Uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement)
  • Any new or unusual muscle movements you cannot control

Stop taking Reglan® and call your doctor at once if you have any of these other serious side effects:

  • Slow or jerky muscle movements, problems with balance or walking
  • Mask-like appearance in your face
  • Very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out
  • Depressed mood, thoughts of suicide or hurting yourself
  • Hallucinations, anxiety, agitation, jittery feeling, trouble staying still
  • Swelling, feeling short of breath, rapid weight gain
  • Jaundice (yellowing of your skin or eyes)
  • Seizure (convulsions)

Less serious Reglan side effects may include:

  • Feeling restless, drowsy, tired, or dizzy
  • Headache, sleep problems (insomnia)
  • Nausea, vomiting, diarrhea
  • Breast tenderness or swelling
  • Changes in your menstrual periods
  • Urinating more than usual

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Reglan® (metoclopramide)?

Reglan® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • Acetaminophen (Tylenol)
  • Cyclosporine (Gengraf, Neoral, Sandimmune)
  • Digoxin (digitalis, Lanoxin)
  • Glycopyrrolate (Robinul)
  • Insulin
  • Levodopa (Larodopa, Atamet, Parcopa, Sinemet)
  • Mepenzolate (Cantil)
  • Tetracycline (Ala-Tet, Brodspec, Panmycin, Sumycin, Tetracap)
  • Atropine (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop)
  • Bladder or urinary medications such as darifenacin (Enablex), flavoxate (Urispas), oxybutynin (Ditropan, Oxytrol), tolterodine (Detrol), or solifenacin (Vesicare)
  • Blood pressure medications
  • Bronchodilators such as ipratroprium (Atrovent) or tiotropium (Spiriva)
  • Irritable bowel medications such as dicyclomine (Bentyl), hyoscyamine (Anaspaz, Cystospaz, Levsin), or propantheline (Pro-Banthine)
  • An MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate)
  • Medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (Clozaril, FazaClo), haloperidol (Haldol), olanzapine (Zyprexa, Symbyax), prochlorperazine (Compazine), risperidone (Risperdal), thiothixene (Navane), and others

Does food or alcohol interact with Reglan® (metoclopramide)?

Reglan® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Reglan® (metoclopramide)?

Reglan® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Health conditions that may interact with this drug are:

  • Kidney disease
  • Liver disease (especially cirrhosis)
  • Congestive heart failure, a heart rhythm disorder
  • High blood pressure
  • Breast cancer
  • Parkinson’s disease
  • Diabetes (your insulin dose may need adjusting)
  • Depression or mental illness


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Reglan® (metoclopramide).

What is the dose of Reglan® (metoclopramide) for an adult?

For the Relief of Symptoms Associated with Diabetic Gastroparesis (Diabetic Gastric Stasis)

If only the earliest manifestations of diabetic gastric stasis are present, oral administration of metoclopramide may be initiated. However, if severe symptoms are present, therapy should begin with Reglan® Injection (IM or IV). Doses of 10 mg may be administered slowly by the intravenous route over a 1- to 2-minute period.

Administration of Reglan® Injection (metoclopramide injection, USP) up to 10 days may be required before symptoms subside, at which time oral administration of metoclopramide may be instituted. The physician should make a thorough assessment of the risks and benefits prior to prescribing further metoclopramide treatment.

For the Prevention of Nausea and Vomiting Associated with Emetogenic Cancer Chemotherapy

Intravenous infusions should be made slowly over a period of not less than 15 minutes, 30 minutes before beginning cancer chemotherapy and repeated every 2 hours for two doses, then every 3 hours for three doses.

The initial two doses should be 2 mg/kg if highly emetogenic drugs such as cisplatin or dacarbazine are used alone or in combination. For less emetogenic regimens, 1 mg/kg per dose may be adequate.

For doses in excess of 10 mg, Reglan® Injection should be diluted in 50 mL of a parenteral solution.

The preferred parenteral solution is Sodium Chloride Injection (normal saline), which when combined with Reglan® Injection, can be stored frozen for up to 4 weeks. Reglan® Injection is degraded when admixed and frozen with Dextrose-5% in Water. Reglan® Injection diluted in Sodium Chloride Injection, Dextrose-5% in Water, Dextrose-5% in 0.45% Sodium Chloride, Ringer’s Injection, or Lactated Ringer’s Injection may be stored up to 48 hours (without freezing) after preparation if protected from light. All dilutions may be stored unprotected from light under normal light conditions up to 24 hours after preparation.

If acute dystonic reactions should occur, inject 50 mg Benadryl® (diphenhydramine hydrochloride) intramuscularly, and the symptoms usually will subside.

For the Prevention of Postoperative Nausea and Vomiting

Reglan® Injection should be given intramuscularly near the end of surgery. The usual adult dose is 10 mg; however, doses of 20 mg may be used.

To Facilitate Small Bowel Intubation

If the tube has not passed the pylorus with conventional maneuvers in 10 minutes, a single dose (undiluted) may be administered slowly by the intravenous route over a 1- to 2-minute period.

The recommended single dose is:

  • Pediatric patients above 14 years of age and adults — 10 mg metoclopramide base.
  • Pediatric patients (6-14 years of age) — 2.5 to 5 mg metoclopramide base; (under 6 years of age) — 0.1 mg/kg metoclopramide base.

To Aid in Radiological Examinations

In patients where delayed gastric emptying interferes with radiological examination of the stomach and/or small intestine, a single dose may be administered slowly by the intravenous route over a 1- to 2-minute period.

For dosage, see intubation above.

What is the dose of Reglan® (metoclopramide) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Reglan® (metoclopramide) available?

Reglan® is available in the following dosage forms and strengths:

  • Injection, solution metoclopramide hydrochloride 5.0mg in 1.0mL

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Reglan®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

msBahasa Malaysia

Review Date: July 26, 2017 | Last Modified: September 13, 2019

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