Generic Name: Rabeprazole Brand Name(s): Generics only. No brands available.


What is Rabeprazole used for?

Rabeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It works by decreasing the amount of acid your stomach makes. It relieves symptoms such as heartburn, difficulty swallowing, and persistent cough. This medication helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus. Rabeprazole belongs to a class of drugs known as proton pump inhibitors (PPIs).

How should I take Rabeprazole?

If you are using the tablets, take your dose by mouth with or without food as directed by your doctor, usually 1 to 2 times daily. Swallow the tablet whole with water. Do not crush, chew, or split the tablet. Doing so can release all of the drug at once, increasing the risk of side effects.

If you are using the capsules, take the dose 30 minutes before a meal as directed by your doctor, usually once daily. Do not swallow the capsule whole. Open the capsule and sprinkle the contents onto a small amount of soft food (such as applesauce or yogurt) or liquid. The food or liquid that you use should be at or below room temperature. Swallow the entire mixture within 15 minutes of preparing it. Do not chew or crush the prepared mixture.

The dosage and length of treatment are based on your medical condition and response to treatment. In children, the dosage is also based on weight.

If needed, antacids may be taken along with this medication. If you are also taking sucralfate, take rabeprazole at least 30 minutes before sucralfate.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day. Continue to take this medication for the prescribed length of treatment even if you are feeling better.

Tell your doctor if your condition persists or worsens. The risk of side effects goes up over time. Ask your doctor how long you should take this medication.

How do I store Rabeprazole?

Rabeprazole is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Rabeprazole in the bathroom or the freezer. There may be different brands of Rabeprazole that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Rabeprazole down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Rabeprazole?

Before taking rabeprazole, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as lansoprazole, omeprazole); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, lupus.

Some symptoms may actually be signs of a more serious condition. Get medical help right away if you have: heartburn with lightheadedness/sweating/dizziness, chest/jaw/arm/shoulder pain (especially with shortness of breath, unusual sweating), unexplained weight loss.

Proton pump inhibitors (such as rabeprazole) may increase your risk for bone fractures, especially with longer use, higher doses, and in older adults. Talk with your doctor or pharmacist about ways to prevent bone loss/fracture, such as by taking calcium (such as calcium citrate) and vitamin D supplements.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. However, similar drugs pass into breast milk. The effects on a nursing infant are unknown. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Rabeprazole during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Rabeprazole. Rabeprazole is pregnancy risk category N according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Rabeprazole?

Headache may occur. If this effect persists or worsens, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: symptoms of a low magnesium blood level (such as unusually fast/slow/irregular heartbeat, persistent muscle spasms, seizures), signs of lupus (such as rash on nose and cheeks, new or worsening joint pain).

This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of bacteria. Do not use anti-diarrhea products or narcotic pain medications if you have any of the following symptoms because these products may make them worse. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain/cramping, fever, blood/mucus in your stool.

Rarely, proton pump inhibitors (such as rabeprazole) have caused vitamin B-12 deficiency. The risk is increased if they are taken every day for a long time (3 years or longer). Tell your doctor right away if you develop symptoms of vitamin B-12 deficiency (such as unusual weakness, sore tongue, or numbness/tingling of the hands/feet).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, signs of kidney problems (such as change in the amount of urine).

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Rabeprazole?

A product that may interact with this drug is: methotrexate (especially high-dose treatment).

Some products need stomach acid so that the body can absorb them properly. Rabeprazole decreases stomach acid, so it may change how well these products work. Some affected products include ampicillin, atazanavir, erlotinib, nelfinavir, pazopanib, rilpivirine, certain azole antifungals (itraconazole, ketoconazole, posaconazole), among others.

This medication may interfere with certain laboratory tests, possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Rabeprazole may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Rabeprazole?

Rabeprazole may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Rabeprazole?

Rabeprazole may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Rabeprazole.

What is the dose of Rabeprazole for an adult?

Usual Adult Dose for Duodenal Ulcer

20 mg orally once a day

-Duration of therapy: 4 weeks

Comment: While most patients achieve ulcer healing after 4 weeks, some patients may need an additional course of therapy to achieve ulcer healing.

Use: Healing and symptomatic relief of duodenal ulcers

Usual Adult Dose for Erosive Esophagitis

20 mg orally once a day

-Duration of therapy: 4 to 8 weeks

Comment: If patients are not healed after 8 weeks, treatment for another 8 weeks may be considered.

Use: Short-term treatment for healing and symptomatic relief of erosive or ulcerative gastroesophageal reflux disease (GERD)

Usual Adult Dose for Gastric Ulcer

20 mg orally once a day

-Duration of therapy: 4 to 8 weeks

Comment: If patients are not healed after 8 weeks, treatment for another 8 weeks may be considered.

Use: Short-term treatment for healing and symptomatic relief of erosive or ulcerative gastroesophageal reflux disease (GERD)

Usual Adult Dose for Duodenal Ulcer Prophylaxis

20 mg orally once a day

-Duration of therapy: Up to 12 months

Comment: Controlled studies for maintenance therapy have not extended beyond 12 months.

Use: Maintenance of healing and reduction in relapse rates of heartburn symptoms in patients with erosive or ulcerative GERD

Usual Adult Dose for Gastroesophageal Reflux Disease

20 mg orally once a day

-Duration of therapy: Up to 4 weeks

Comment: If symptoms do not resolve after 4 weeks of therapy, an additional course of treatment may be considered.

Use: Treatment of daytime and nighttime heartburn and other symptoms associated with GERD

Usual Adult Dose for Helicobacter pylori Infection

20 mg orally 2 times a day, taken concomitantly with amoxicillin and clarithromycin

-Duration of therapy: 7 days


-Refer to the manufacturer product information for dosing for amoxicillin and clarithromycin.

-All medications should be taken with morning and evening meals.

-Eradication of Helicobacter pylori has been shown to decrease the risk of duodenal ulcer recurrence.

-Patients who fail therapy should undergo susceptibility testing and/or begin alternative antimicrobial therapy.

Use: Treatment and eradication of H pylori and active/history of duodenal ulcer disease within 5 years

Usual Adult Dose for Zollinger-Ellison Syndrome

Initial dose: 60 mg orally once a day

Maintenance dose: 60 mg orally 2 times a day or 100 mg orally once a day

Duration of therapy: Up to 1 year


-Doses should be patient-specific and should continue for as long as clinically necessary.

-Divided dosing may be required in some patients.

Use: Long-term treatment of pathological hypersecretory conditions (e.g., Zollinger-Ellison syndrome)

Other Comments

Administration advice:

-Avoid chewing/crushing/splitting the dose form.

-Tablets may be taken without regard to food.

-Capsule/granules should be taken 30 minutes before a meal.

Storage requirements: The manufacturer product information should be consulted.


-Patients on long-term therapy should be evaluated regularly for the continued need of this drug.

-Compliance for once a day dosing may improve if this drug is taken in the morning before eating.

-There are no data for use with antibiotic therapy in patients with renal or hepatic impairment.

-Patients using this drug to treat gastroesophageal reflux disease symptoms for longer than 6 months should be further reevaluated.


-Magnesium levels, especially in patients taking other drugs that could result in hypomagnesemia or those on long-term therapy

-Vitamin B12 levels, especially in patients on long-term therapy

-Bone fractures, especially in patients at high risk for osteoporosis-related events

-Calcium and vitamin D levels, especially in patients on long-term therapy

-INR and prothrombin time in patients receiving concomitant treatment with warfarin

Patient advice:

-Capsules may be opened and sprinkled onto room temperature or colder soft food or into a small amount of liquid. Patients should consume the whole dose within 15 minutes of preparation.

-If using this drug to treat Helicobacter pylori, tell patients that it is important to complete the 7-day regimen.

-Instruct patients to seek medical attention if signs/symptoms of hypersensitivity, Clostridium difficile, or systemic cutaneous lupus erythematosus occur.

-Advise patients to speak to their healthcare provider if they become pregnant, intend to become pregnant, or are breastfeeding.

What is the dose of Rabeprazole for a child?

Usual Pediatric Dose for Gastroesophageal Reflux Disease

1 to 11 years:

Less than 15 kg: 5 mg orally once a day, with the option to increase to 10 mg if inadequate response

15 kg or more: 10 mg orally once a day

Duration of therapy: Up to 12 weeks

12 years or older: 20 mg orally once a day

-Duration of therapy: Up to 8 weeks


-Treatment of GERD

-Treatment of symptomatic GERD

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Mild to moderate hepatic impairment (Child-Pugh A and B): No adjustment recommended.

Severe hepatic impairment (Child-Pugh C): Use with caution.


Safety and efficacy have not been established in patients younger than 1 year (some granule formulations) and 12 years (some tablet formulations).

How is Rabeprazole available?

Rabeprazole is available in the following dosage forms and strengths:

  • Oral delayed release tablet,
  • Oral delayed release capsule.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Rabeprazole, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: April 21, 2018 | Last Modified: April 21, 2018

You might also like