Quinapril

By Medically reviewed by hellodoktor

Generic Name: Quinapril Brand Name(s): Quinapril.

Uses

What is Quinapril used for?

Quinapril is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This medication is also used to treat heart failure. Quinapril belongs to a class of drugs known as ACE inhibitors. It works by relaxing blood vessels so blood can flow more easily.

How should I take Quinapril?

Take this medication by mouth with or without food as directed by your doctor, usually once or twice a day. High-fat meals may decrease the absorption of this medication.

To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor’s instructions carefully.

The dosage is based on your medical condition and response to treatment.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day. Keep taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

For the treatment of high blood pressure, it may take 1 to 2 weeks before you get the full benefit of this medication. For the treatment of heart failure, it may take weeks to months before you get the full benefit of this medication.

This product contains magnesium which may interfere with the absorption of some medications. See the Drug Interactions section and consult your pharmacist for more information.

Tell your doctor if your condition does not get better or if it gets worse (for example, your blood pressure readings remain high or increase).

How do I store Quinapril?

Quinapril is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Quinapril in the bathroom or the freezer. There may be different brands of Quinapril that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Quinapril down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Quinapril?

Before taking quinapril, tell your doctor or pharmacist if you are allergic to it; or to other ACE inhibitors (such as benazepril); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of an allergic reaction which included swelling of the face/lips/tongue/throat (angioedema), blood filtering procedures (such as LDL apheresis, dialysis), high level of potassium in the blood, liver disease.

This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

Too much sweating, diarrhea, or vomiting may cause loss of too much body water (dehydration) and increase your risk of lightheadedness. Report prolonged diarrhea or vomiting to your doctor. Be sure to drink enough fluids to prevent dehydration unless your doctor directs you otherwise.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This product may increase your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist.

Older adults may be more sensitive to the side effects of this drug, including dizziness and increases in potassium level.

This medication is not recommended for use during pregnancy. It may harm an unborn baby. Consult your doctor for more details. See also Warning section.

This medication passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Quinapril during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Quinapril. Quinapril is pregnancy risk category D according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Quinapril?

Dizziness, lightheadedness, or tiredness may occur as your body adjusts to the medication. Dry cough, nausea, or vomiting may also occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: symptoms of a high potassium blood level (such as muscle weakness, slow/irregular heartbeat), fainting.

Although quinapril may be used to prevent kidney problems or treat people who have kidney problems, it may also rarely cause serious kidney problems or make them worse. Your doctor will check your kidney function while you are taking quinapril. Tell your doctor right away if you have any signs of kidney problems such as a change in the amount of urine.

This drug may rarely cause serious (possibly fatal) liver disease. Get medical help right away if you have any symptoms of liver damage, such as: nausea/vomiting that doesn’t stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Quinapril?

Some products that may interact with this drug include: aliskiren, gold injections, lithium, sacubitril, certain drugs that weaken the immune system/increase the risk of infection (such as everolimus, sirolimus), drugs that may increase the level of potassium in the blood (such as ARBs including losartan/valsartan, birth control pills containing drospirenone).

This product contains magnesium which can interfere with your body’s ability to absorb certain drugs, especially if you take them around the same time. These drugs include quinolone antibiotics (such as ciprofloxacin, levofloxacin), tetracycline antibiotics (such as doxycycline, minocycline), thyroid medications (such as levothyroxine), and drugs for osteoporosis (bisphosphonates such as alendronate). This is not a complete list. Ask your doctor or pharmacist how long to wait between doses and when you should take your medications.

Some products have ingredients that could raise your blood pressure or worsen your heart failure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).

A very serious reaction may occur if you are getting injections for bee/wasp sting allergy (desensitization) and are also taking quinapril. Make sure all your doctors know which medicines you are using.

Quinapril may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Quinapril?

Quinapril may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Quinapril?

Quinapril may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Quinapril.

What is the dose of Quinapril for an adult?

Usual Adult Dose for Hypertension

Initial dose: 10 or 20 mg orally once a day in patients not on diuretics

Maintenance dose: 20 to 80 mg orally per day, administered as a single dose or in two equally divided doses

Use:

-Treatment of hypertension

Usual Adult Dose for Congestive Heart Failure

Initial dose: 5 mg orally twice a day

Maintenance dose: 20 to 40 mg orally per day administered in two equally divided doses

Comments:

-This dose may improve symptoms of heart failure, but increases in exercise duration have generally required higher doses.

-If the initial dosage is well tolerated, patients should then be titrated at weekly intervals until an effective dose.

Use:

-Management of heart failure as adjunctive therapy when added to conventional therapy including diuretics and/or digitalis

Usual Geriatric Dose for Congestive Heart Failure

10 mg orally once a day

Comments: Dose should be titrated the same way as for other adult patients.

Uses:

-Treatment of hypertension

-Management of heart failure as adjunctive therapy when added to conventional therapy including diuretics and/or digitalis

Usual Geriatric Dose for Hypertension

10 mg orally once a day

Comments: Dose should be titrated the same way as for other adult patients.

Uses:

-Treatment of hypertension

-Management of heart failure as adjunctive therapy when added to conventional therapy including diuretics and/or digitalis

Renal Dose Adjustments

CrCl greater than 60 mL/min: Initial dose: 10 mg orally once a day

CrCl 30 to 60 mL/min: Initial dose: 5 mg orally once a day

CrCl 10 to 30 mL/min: Initial dose: 2.5 mg orally once a day

Dose Adjustments

-Doses used for hypertension should be adjusted according to blood pressure response measured at peak (2 to 6 hours after dosing) and trough (predosing). Usually, dosage adjustments should be made at intervals of at least 2 weeks.

-In patients in whom the antihypertensive effect may diminish toward the end of the dosing interval, an increase in dosage or twice a day administration may be justified. Doses of 40 to 80 mg and divided doses give a greater effect at the end of the dosing interval.

-Doses used for heart failure should be titrated at weekly intervals until an effective dose is reached or undesirable hypotension, orthostasis, or azotemia precludes this dose titration.

-If blood pressure is not controlled, a diuretic can be added. An initial dose of 5 mg orally once a day should be administered with medical supervision and until blood pressure has stabilized.

-In the absence of excessive hypotension or significant deterioration of renal function, the dose may be increased at weekly intervals based on clinical and hemodynamic response.

Dialysis

Hemodialysis and peritoneal dialysis: Little effect on the elimination of quinapril

Other Comments

Administration advice:

-If blood pressure is not adequately controlled with quinapril monotherapy, a diuretic may be added.

-To reduce the likelihood of hypotension, the diuretic should, if possible, be discontinued 2 to 3 days prior to beginning therapy with quinapril.

Storage requirements:

-Protect from light

Monitoring:

-Cardiovascular: Closely monitor blood pressure

-Renal: Closely monitor renal function

-Metabolic: Closely monitor electrolytes

What is the dose of Quinapril for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Quinapril available?

Quinapril is available in the following dosage forms and strengths:

  • Oral tablet.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Quinapril, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: April 21, 2018 | Last Modified: September 12, 2019

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