Quinapril + Hydrochlorothiazide

By Medically reviewed by hellodoktor

Generic Name: Quinapril + Hydrochlorothiazide Brand Name(s): Quinapril + Hydrochlorothiazide.

Uses

What is Quinapril + Hydrochlorothiazide used for?

Quinapril + Hydrochlorothiazide is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.

This product contains 2 medications: quinapril and hydrochlorothiazide. Quinapril belongs to a class of drugs known as ACE inhibitors and works by relaxing blood vessels so blood can flow more easily. Hydrochlorothiazide belongs to a class of drugs known as diuretics/”water pills.” It works by causing you to make more urine. This helps your body get rid of extra salt and water.

How should I take Quinapril + Hydrochlorothiazide?

Take this medication by mouth with or without food as directed by your doctor, usually once daily in the morning. If you take this drug too close to bedtime, you may need to wake up to urinate. It is best to take this medication at least 4 hours before your bedtime.

The dosage is based on your medical condition and response to treatment.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Keep taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

It may take several weeks before you get the full benefit of this product.

This product contains magnesium which may interfere with the absorption of some medications.

If you also take certain drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol), take this product at least 4 hours before or at least 4 to 6 hours after these medications.

Tell your doctor if your condition does not get better or if it gets worse (your blood pressure readings remain high or increase).

How do I store Quinapril + Hydrochlorothiazide?

Quinapril + Hydrochlorothiazide is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Quinapril + Hydrochlorothiazide in the bathroom or the freezer. There may be different brands of Quinapril + Hydrochlorothiazide that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Quinapril + Hydrochlorothiazide down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Quinapril + Hydrochlorothiazide?

Before taking this product, tell your doctor or pharmacist if you are allergic to either quinapril or hydrochlorothiazide; or to other ACE inhibitors (such as captopril, lisinopril); or to thiazides (such as chlorothiazide); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: history of an allergic reaction which included swelling of the face/lips/tongue/throat (angioedema), blood filtering procedures (such as LDL apheresis, dialysis), gout, kidney problems, liver disease, loss of too much body water (dehydration), untreated mineral imbalances (such as high or low potassium), lupus.

This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Severe sweating, diarrhea, or vomiting can increase the risk for a serious loss of body water (dehydration). Report prolonged diarrhea or vomiting to your doctor. To prevent dehydration, drink plenty of fluids unless your doctor directs you otherwise.

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

This product may affect your potassium levels. Before using potassium supplements or salt substitutes containing potassium, consult your doctor or pharmacist.

If you have diabetes, this product may affect your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Tell your doctor right away if you have symptoms of high blood sugar such as increased thirst/urination. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

Older adults may be more sensitive to the side effects of this drug, especially change in the amount of urine (kidney problems) and dizziness.

This medication is not recommended for use during pregnancy due to the risk for harm to an unborn baby. Consult your doctor for more details. This medication passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Quinapril + Hydrochlorothiazide during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Quinapril + Hydrochlorothiazide. Quinapril + Hydrochlorothiazide is pregnancy risk category D according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Quinapril + Hydrochlorothiazide?

Tiredness, headache, dizziness, or lightheadedness may occur as your body adjusts to the medication. Dry cough may also occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This product may cause a loss of too much body water (dehydration) and salt/minerals. Tell your doctor right away if you have any symptoms of dehydration or mineral loss, including: extreme thirst, very dry mouth, muscle cramps/weakness, fast/slow/irregular heartbeat, confusion, decreased urination.

Tell your doctor right away if you have any serious side effects, including: signs of kidney problems (such as change in the amount of urine), symptoms of a high potassium blood level (such as muscle weakness, slow/irregular heartbeat), fainting, decrease in vision, eye pain.

This drug may rarely cause serious (possibly fatal) liver disease. Get medical help right away if you have any symptoms of liver damage, such as: nausea/vomiting that doesn’t stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat/neck), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Quinapril + Hydrochlorothiazide?

Some products that may interact with this drug are: aliskiren, dofetilide, lithium, gold injections, sacubitril, certain drugs that weaken the immune system/increase the risk of infection (such as everolimus, sirolimus), drugs that may increase the level of potassium in the blood (such as ARBs including losartan/valsartan, birth control pills containing drospirenone).

This product contains magnesium which can interfere with your body’s ability to absorb certain drugs, especially if you take them around the same time. These drugs include quinolone antibiotics (such as ciprofloxacin, levofloxacin), tetracycline antibiotics (such as doxycycline, minocycline), thyroid medications (such as levothyroxine), and drugs for osteoporosis (bisphosphonates such as alendronate). This is not a complete list. Ask your doctor or pharmacist how long to wait between doses and when you should take your medications.

Some products have ingredients that could raise your blood pressure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).

A very serious reaction may occur if you are getting injections for bee/wasp sting allergy (desensitization) and are also taking quinapril/hydrochlorothiazide. Make sure all your doctors know which medicines you are using.

This product may interfere with certain lab tests (such as parathyroid function), possibly causing false test results. Make sure lab personnel and all your doctors know you use this product.

Quinapril + Hydrochlorothiazide may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Quinapril + Hydrochlorothiazide?

Quinapril + Hydrochlorothiazide may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Quinapril + Hydrochlorothiazide?

Quinapril + Hydrochlorothiazide may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Quinapril + Hydrochlorothiazide.

What is the dose of Quinapril + Hydrochlorothiazide for an adult?

Usual Adult Dose for Hypertension

Hydrochlorothiazide 12.5 to 25 mg-quinapril 10 to 20 mg orally once a day

Comments:

-The initial dosage of hydrochlorothiazide-quinapril should be based on the patient requirements for each drug individually.

Renal Dose Adjustments

CrCl less than 25 mL/min: Not recommended

Liver Dose Adjustments

Caution is recommended.

What is the dose of Quinapril + Hydrochlorothiazide for a child?

Dialysis

Quinapril is not removed by hemodialysis or peritoneal dialysis.

Other Comments

-Hydrochlorothiazide-quinapril should be administered at the same time each day without regard to food.

-In patients with renal impairment requiring concomitant diuretic therapy, a loop diuretic is preferred over a thiazide diuretic.

How is Quinapril + Hydrochlorothiazide available?

Quinapril + Hydrochlorothiazide is available in the following dosage forms and strengths:

  • Oral tablet

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Quinapril + Hydrochlorothiazide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: April 21, 2018 | Last Modified: September 12, 2019

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