Generic Name: Provigil Brand Name(s): Generics only. No brands available.

Uses

What is Provigil® (modafinil) used for?

Provigil® is commonly used for treating excessive sleepiness due to narcolepsy and other sleep disorders, such as periods of stopped breathing during sleep (obstructive sleep apnea). It is also used to help you stay awake during hours if you have a work schedule that keeps you from having a normal sleep routine (shift work sleep disorder).

This medication does not cure these sleep disorders and may not get rid of all your sleepiness. Provigil® does not take the place of getting enough sleep. It should not be used to treat tiredness or hold off sleep in people who do not have a sleep disorder.

How should I take Provigil® (modafinil)?

For narcolepsy, take this medication by mouth with or without food as directed by your doctor, usually once daily in the morning. If your doctor directs you to, the total daily dose of Provigil® may be divided into a morning dose and a noon dose.

For obstructive sleep apnea, take this medication by mouth with or without food as directed by your doctor, usually once daily in the morning. Continue your other treatment (such as the CPAP machine, mouth device) unless your doctor tells you to stop.

If you are using modafinil for shift work sleep disorder, take it by mouth with or without food as directed by your doctor, usually once a day 1 hour before you start your work shift.

Modafinil may be addictive. Do not share Provigil® with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or distributing this medicine is illegal.

How do I store Provigil® (modafinil)?

Provigil® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Provigil® in the bathroom or the freezer. There may be different brands of Provigil® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Provigil® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Provigil® (modafinil)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Provigil® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

You should not use Provigil® if you have ever had an allergic reaction or skin rash while taking modafinil or armodafinil (Nuvigil).

To make sure Provigil® is safe for you, tell your doctor if you have:

  • Angina (chest pain)
  • Cirrhosis or other liver problem
  • Kidney disease
  • High blood pressure, heart disease, or history of heart attack
  • A history of mental illness or psychosis
  • History of alcoholism or drug addiction

Provigil® can make certain birth control less effective. Hormonal contraception (birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment. Talk with your doctor about the best methods of birth control to use while taking Provigil®.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Provigil® (modafinil)?

Common side effects may include:

  • Headache, dizziness
  • Feeling nervous or anxious
  • Back pain
  • Nausea, diarrhea, upset stomach
  • Sleep problems (insomnia)
  • Stuffy nose

Stop using Provigil® and call your doctor at once if you have:

  • Depression, anxiety, suicidal thoughts or actions
  • Hallucinations, unusual thoughts or behavior, aggression, being more active or talkative than usual
  • Chest pain, trouble breathing, uneven heart beats
  • The first sign of any skin rash, no matter how minor you think it might be

Get emergency medical help if you have signs of an allergic reaction to Provigil: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Provigil® can cause skin reactions that may be severe enough to need treatment in a hospital. Stop taking this medicine and get emergency medical help if you have:

  • Skin rash or hives, blisters or peeling
  • Mouth sores, trouble swallowing
  • Fever, shortness of breath
  • Swelling in your legs
  • Dark urine, jaundice (yellowing of the skin or eyes)
  • Swelling in your face, eyes, lips, tongue, or throat

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Provigil® (modafinil)?

Provigil® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are street drugs (such as methamphetamine, MDMA/”ecstasy”).

Does food or alcohol interact with Provigil® (modafinil)?

Provigil® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Provigil® (modafinil)?

Provigil® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Health conditions that may interact with this drug are:

  • Cardiac Disease
  • Hypertension
  • Liver Disease
  • Seizure Disorders
  • Psychiatric Disorders
  • Renal Dysfunction
  • Cardiovascular

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of Provigil® (modafinil) for an adult?

For Narcolepsy:

200 orally daily in the morning

For Obstructive Sleep Apnea/Hypopnea Syndrome:

200 orally daily in the morning

For Shift Work Sleep Disorder:

200 mg orally daily one hour prior to the start of the work shift

What is the dose of Provigil® (modafinil) for a child?

There isn’t enough information about the safety of using this medication during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication.

How is Provigil® (modafinil) available?

Provigil® is available in the following dosage forms and strengths:

  • Tablet: modafinil 100mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Provigil®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: September 2, 2017 | Last Modified: September 2, 2017

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