What is Propantheline used for?
Propantheline is used with other medications to treat peptic ulcers. It works by decreasing the release of acid in the stomach.
How should I take Propantheline?
Take this medication by mouth, usually 30 minutes before each meal and at bedtime or as directed by your doctor.
Dosage is based on your medical condition and response to therapy.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.
Inform your doctor if your condition persists or worsens.
How do I store Propantheline?
Propantheline is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Propantheline in the bathroom or the freezer. There may be different brands of Propantheline that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.
You should not flush Propantheline down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.
Precautions & warnings
What should I know before using Propantheline?
Before taking propantheline, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: glaucoma, myasthenia gravis, movement/blockage disorders of the stomach/bowels (e.g., paralytic ileus, pyloroduodenal stenosis, achalasia, intestinal atony), difficulty urinating (e.g., prostatic hypertrophy), overactive thyroid (hyperthyroidism), liver disease, kidney disease, high blood pressure, heart/blood vessel disease (e.g., congestive heart failure, coronary artery disease, tachycardia), esophagus problems (e.g., GERD), nerve disorders (e.g., autonomic neuropathy), diarrhea, breathing problems (e.g., asthma), ulcerative colitis.
Before having surgery, tell your doctor or dentist that you are using this medication.
This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.
This medication can decrease sweating. To prevent heatstroke, avoid becoming overheated in hot weather, in saunas, and during exercise/other strenuous activities.
Caution is advised when using this drug in the elderly because they may be more sensitive to the side effects.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.
Is it safe during pregnancy or breast-feeding?
There are no adequate studies in women for determining risk when using this Propantheline during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Propantheline. Propantheline is pregnancy risk category C according to the US Food and Drug Administration (FDA).
FDA pregnancy risk category reference below:
- A=No risk,
- B=No risk in some studies,
- C=There may be some risk,
- D=Positive evidence of risk,
What side effects can occur from Propantheline?
Dry mouth, decreased sweating, dizziness, drowsiness, blurred vision, widened pupils, nausea/vomiting, or constipation may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Tell your doctor right away if any of these unlikely but serious side effects occur: mental/mood changes, eye pain/pressure, fast/pounding heartbeat, difficulty urinating.
A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.
What drugs may interact with Propantheline?
Some products that may interact with this drug include: antispasmodics (e.g., dicyclomine), belladonna alkaloids (e.g., scopolamine, atropine), certain antiarrhythmic drugs (e.g., quinidine), certain drugs for Parkinson’s disease (e.g., benztropine, trihexyphenidyl), corticosteroids (e.g., prednisone), digoxin (slow-dissolving type), drugs which depend on stomach acidity (e.g., ketoconazole), MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine), phenothiazines (e.g., chlorpromazine), potassium tablets/capsules, pramlintide, tricyclic antidepressants (e.g., amitriptyline).
Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana, drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).
Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.
Propantheline may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.
Does food or alcohol interact with Propantheline?
Propantheline may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.
What health conditions may interact with Propantheline?
Propantheline may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.
The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Propantheline.
What is the dose of Propantheline for an adult?
Usual Adult Dose for Peptic Ulcer
Initial dose: 15 mg orally taken 30 minutes before each meal and 30 mg orally at bedtime (a total of 75 mg/day)
Patients with mild manifestations and patients of small stature may be given 7.5 mg orally 3 times a day, taken 30 minutes before each meal.
Usual Geriatric Dose for Peptic Ulcer
Initial dose: 7.5 mg orally 3 times a day, taken 30 minutes before each meal
Renal Dose Adjustments
The manufacturer recommends caution when administering this drug to patients with renal disease.
Liver Dose Adjustments
The manufacturer recommends caution when administering this drug to patients with hepatic disease.
Subsequent dosage adjustment should be made according to the patient’s individual response and tolerance.
Propantheline is contraindicated in patients with glaucoma, obstructive disease of the gastrointestinal tract, obstructive uropathy, intestinal atony of the elderly or debilitated patient, severe ulcerative colitis or toxic megacolon complicating ulcerative colitis, unstable cardiovascular adjustment in acute hemorrhage, and myasthenia gravis.
Propantheline should be used with caution in the elderly and in all patients with autonomic neuropathy, hyperthyroidism, coronary heart disease, congestive heart failure, cardiac tachyarrhythmias, hypertension, or hiatal hernia associated with reflux esophagitis.
Because gastrointestinal antispasmodics are highly anticholinergic drugs, propantheline meets Beers criteria as a medication that is potentially inappropriate for use in older adults.
With overdose, a curare-like action may occur, characterized by muscular weakness and possible paralysis.
Propantheline may cause drowsiness or blurred vision. Patients should be cautioned regarding activities requiring mental alertness (such as operating a motor vehicle or other machinery or performing hazardous work) while taking this drug.
What is the dose of Propantheline for a child?
The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.
How is Propantheline available?
Propantheline is available in the following dosage forms and strengths:
- Oral tablet,
- Compounding powder.
What should I do in case of an emergency or overdose?
In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.
What should I do if I miss a dose?
If you miss a dose of Propantheline, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.
Hello Health Group does not provide medical advice, diagnosis or treatment.
Propantheline Dosage. https://www.drugs.com/dosage/propantheline.html. Accessed April 9, 2018.
Propantheline BROMIDE. https://www.webmd.com/drugs/2/drug-3946/propantheline-oral/details. Accessed April 9, 2018.
Review Date: April 21, 2018 | Last Modified: April 21, 2018