By Medically reviewed by hellodoktor

Generic Name: Progestogel Brand Name(s): Progestogel.


What is Progestogel (progesterone) used for?

Progestogel is vaginal gel containing progesterone. It is commonly used for:

  • Treating certain women who do not menstruate.
  • Treating the secondary amenorrhea (absence of menses).
  • Supplementing or replacing progesterone in infertile women with progesterone deficiency who are receiving treatment utilizing assisted reproductive technology.

How should I take Progestogel (progesterone)?

Use progesterone gel as directed by your doctor. Check the label on the medicine for exact dosing instructions.

How do I store Progestogel (progesterone)?

Progestogel is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Progestogel in the bathroom or the freezer. There may be different brands of Progestogel that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Progestogel down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Progestogel (progesterone)?

Before using Progestogel, tell your doctor if you have:

  • Allergic reaction to excipients using for dosage form containing Progestogel.
  • Allergic reaction to any other medicines, foods, dyes, preservatives, or animals.
  • Used any other health conditions, drugs that have a risk of interaction with Progestogel.

Is it safe during pregnancy or breastfeeding?


In case of corpus luteum deficiency, Progestogel can be used during the first month of pregnancy.


Do not use during lactation.

Side effects

What side effects can occur from Progestogel (progesterone)?

As taking others medicines, taking Progestogel can cause some side effects. Most of them are rarely occurring and do not need any supplementary treatment. However, it is always important for you to consult your doctor if you have any problem after taking this medicine.

Some of side effects are listed below:

  • Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue)
  • Abnormal vaginal bleeding
  • Breast lumps
  • Change in emotions, mood, or behavior
  • Coughing blood
  • Inflammation of the eye
  • Numbness of arm or leg
  • One-sided weakness
  • Pain in the groin
  • Partial or complete loss of vision
  • Seizure
  • Stomach pain, swelling, or tenderness
  • Sudden, severe headache, vomiting, dizziness, or fainting
  • Swelling of hands, ankles, or feet
  • Tremor
  • Unusual vaginal discharge or odor
  • Visual or speech disturbances
  • Yellowing of the skin or eyes
  • Breast enlargement
  • Constipation
  • Cramps
  • Depression
  • Diarrhea
  • Difficult or painful sexual intercourse
  • Drowsiness
  • Fatigue
  • Fluid retention/bloating
  • Increased appetite
  • Joint pain
  • Nausea
  • Nervousness
  • Pain around vaginal area
  • Sleep disorder
  • Urination at night

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Progestogel (progesterone)?

Progestogel may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Progestogel (progesterone)?

Progestogel may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Progestogel (progesterone)?

Progestogel may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Progestogel.

What is the dose of Progestogel (progesterone) for an adult?

Consult your doctor for information about the dose of Progestogel.

Recommended doses in some cases are listed below:

Treatment of infertility due to inadequate luteal phase: the recommended dose is one application (1.125g 8% gel) every day, starting after documented ovulation or arbitrarily on the 18th – 21st day of the cycle.

Use during in-vitro fertilization: daily application should be continued for 30 days if there is laboratory evidence of pregnancy.

What is the dose of Progestogel (progesterone) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Progestogel (progesterone) available?

Progestogel is available in the following dosage forms and strengths:

  • Gel; Local; Progesterone 1%

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Progestogel, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Review Date: January 13, 2017 | Last Modified: September 12, 2019

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