Generic Name: Prilosec Brand Name(s): Prilosec.

Uses

What is Prilosec® (omeprazole) used for?

Prilosec® is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Prilosec® is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions caused by excess stomach acid. Omeprazole is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid).

Prilosec® may also be given together with antibiotics to treat gastric ulcer caused by infection with helicobacter pylori (H. pylori).

Prilosec® is not for immediate relief of heartburn symptoms.

How should I take Prilosec® (omeprazole)?

Prilosec® is usually taken before eating (at least 1 hour before a meal). Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Prilosec® OTC (over-the-counter) should be taken only once every 24 hours for 14 days. Take the medicine in the morning before you eat breakfast. It may take up to 4 days for full effect. Do not take more than one tablet every 24 hours.

Allow at least 4 months to pass before you start another 14-day treatment with Prilosec® OTC. Call your doctor if you have additional symptoms and need treatment before the 4 months has passed.

Do not crush, chew, or break a delayed release tablet, or a Prilosec® OTC tablet. Swallow the tablet whole.

You may open the delayed-release capsule and sprinkle the medicine into a spoonful of applesauce to make swallowing easier. Swallow the mixture right away without chewing. Do not save for later use.

Use Prilosec® for the full prescribed length of time. Your symptoms may improve before your condition is completely cleared.

How do I store Prilosec® (omeprazole)?

Prilosec® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Prilosec® in the bathroom or the freezer. There may be different brands of Prilosec® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Prilosec® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Prilosec® (omeprazole)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Prilosec® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, and a general ill feeling.

Taking a proton pump inhibitor such as Prilosec® may increase your risk of bone fracture in the hip, wrist, or spine. This effect has occurred mostly in people who have taken the medication long term or at high doses, and in those who are age 50 and older. It is not clear whether Prilosec® is the actual cause of an increased risk of fracture.

Some conditions are treated with a combination of Prilosec® and antibiotics. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor’s advice.

It is not known whether Prilosec® will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Omeprazole can pass into breast milk and may harm a nursing baby. Do not use Prilosec without a doctor’s advice if you are breast-feeding.

This medicine can cause unusual results with certain medical tests, and you may need to stop using the medicine for a short time before a test. Tell any doctor who treats you that you are using Prilosec®.

Do not give Prilosec to a child younger than 1year old without the advice of a doctor.

If you use Prilosec® for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it.

Call your doctor if your symptoms do not improve, or if they get worse while using Prilosec®.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Prilosec® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Prilosec®. Prilosec® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Prilosec® (omeprazole)?

Get emergency medical help if you have signs of an allergic reaction to Prilosec: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • Severe stomach pain, diarrhea that is watery or bloody
  • Seizure (convulsions)
  • Kidney problems–urinating more or less than usual, blood in your urine, swelling, rapid weight gain
  • Symptoms of low magnesium–dizziness, confusion; fast or uneven heart rate; tremors (shaking) or jerking muscle movements; feeling jittery; muscle cramps, muscle spasms in your hands and feet; cough or choking feeling

Common side effects may include:

  • Stomach pain, gas
  • Nausea, vomiting, diarrhea
  • Headache

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Prilosec® (omeprazole)?

Prilosec® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • Cilostazol
  • Clopidogrel
  • Diazepam (Valium)
  • Digoxin
  • Disulfiram (Antabuse)
  • Erlotinib
  • Iron-containing medicines (ferrous fumarate, ferrous gluconate, ferrous sulfate, and others)
  • Methotrexate
  • Mycophenolate mofetil
  • Phenytoin
  • John’s wort
  • Tacrolimus
  • Warfarin (Coumadin, Jantoven)
  • An antibiotic–ampicillin, amoxicillin, clarithromycin, rifampin
  • Antifungal medicine–ketoconazole, voriconazole
  • HIV or AIDS medication–atazanavir, nelfinavir, saquinavir

Does food or alcohol interact with Prilosec® (omeprazole)?

Prilosec® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Prilosec® (omeprazole)?

Prilosec® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Health conditions that may interact with this drug are:

  • Liver disease
  • Low levels of magnesium in your blood
  • Osteoporosis or low bone mineral density (osteopenia)
  • Trouble or pain with swallowing
  • Bloody or black stools, vomit that looks like blood or coffee grounds
  • Heartburn that has lasted for over 3 months
  • Frequent chest pain, heartburn with wheezing
  • Unexplained weight loss
  • Nausea or vomiting, stomach pain

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Prilosec® (omeprazole).

What is the dose of Prilosec® (omeprazole) for an adult?

Usual Adult Dose of Prilosec for Duodenal Ulcer:

20 mg orally once a day before a meal. Most patients heal within 4 to 8 weeks.

Usual Adult Dose for Helicobacter pylori Infection:

Dual therapy: omeprazole 40 mg orally once a day in the morning plus clarithromycin 500 mg orally 3 times a day on days 1 to 14. Beginning on day 15, omeprazole 20 mg orally once a day in the morning on days 15 to 28.

Triple therapy: omeprazole 20 mg plus clarithromycin 500 mg plus amoxicillin 1000 mg all given orally twice a day for 10 days. If an ulcer is present at the initiation of therapy, continue omeprazole 20 mg orally once a day for an additional 18 days.

Usual Adult Dose of Prilosec for Gastric Ulcer:

40 mg orally once a day before a meal for 4 to 8 weeks.

Usual Adult Dose for Erosive Esophagitis:

20 mg orally once a day before a meal. This dosage may be increased to 40 mg per day based on desired clinical response and patient tolerance. Studies have been completed up to 12 months for maintenance therapy of erosive esophagitis.

Usual Adult Dose for Zollinger-Ellison Syndrome:

Initial: 60 mg orally once a day. Dosage should be individualized to patient’s needs.

Maintenance: doses up to 120 mg 3 times a day have been administered. Daily doses greater than 80 mg should be divided.

Usual Adult Dose for Gastroesophageal Reflux Disease:

Initial: 20 mg orally once a day before a meal for 4 to 8 weeks. This dosage may be increased to 40 mg per day if needed.

Maintenance: long-term treatment with doses of 10 to 20 mg per day may be required for maintenance therapy of refractory disease and appears to be safe.

Usual Adult Dose for Multiple Endocrine Adenomas:

Initial: 60 mg orally once a day before a meal. This dosage may be titrated based on desired clinical response and patient tolerance.

Maintenance: doses up to 120 mg 3 times a day have been administered. Daily doses greater than 80 mg should be divided.

Usual Adult Dose for Systemic Mastocytosis:

Initial: 60 mg orally once a day before a meal. This dosage may be titrated based on desired clinical response and patient tolerance.

Maintenance: doses up to 120 mg 3 times a day have been administered. Daily doses greater than 80 mg should be divided.

Usual Adult Dose for Dyspepsia:

Prevention of frequent heartburn: 20 mg orally once daily, before a meal, for 14 days.

What is the dose of Prilosec® (omeprazole) for a child?

Usual Pediatric Dose for Erosive Esophagitis:

Oral:

Infants:

GERD: 0.7 mg/kg/dose once daily reduced the percentage of time gastric and esophageal pH less than 4, as well as the number of reflux episodes in 10 neonates [mean PMA: 36.1 weeks, (34 to 40 weeks)] in a trial. Higher doses of 1 to 1.5 mg/kg/day have been reported.

Children and Adolescents 1 to 16 years:

GERD, ulcers, esophagitis:

Manufacturer recommendations:

  • 5 kg to less than 10 kg: 5 mg once daily
  • 10 kg to less than or equal to 20 kg: 10 mg once daily
  • Greater than 20 kg: 20 mg once daily

Alternate dosing:

Children 1 to 16 years:

  • 1 mg/kg/dose once or twice daily
  • Adjunctive therapy of duodenal ulcers associated with Helicobacter pylori (in combination with antibiotic therapy either clarithromycin or clarithromycin and amoxicillin) in children:
  • 15 to 30 kg: 10 mg twice daily
  • Greater than 30 kg: 20 mg twice daily

Usual Pediatric Dose for Gastroesophageal Reflux Disease:

Oral:

Infants:

GERD: 0.7 mg/kg/dose once daily reduced the percentage of time gastric and esophageal pH less than 4, as well as the number of reflux episodes in 10 neonates [mean PMA: 36.1 weeks, (34 to 40 weeks)] in a trial. Higher doses of 1 to 1.5 mg/kg/day have been reported

Children and Adolescents 1 to 16 years:

GERD, ulcers, esophagitis:

Manufacturer recommendations:

  • 5 kg to less than 10 kg: 5 mg once daily
  • 10 kg to less than or equal to 20 kg: 10 mg once daily
  • Greater than 20 kg: 20 mg once daily

Alternate dosing:

Children 1 to 16 years:

  • 1 mg/kg/dose once or twice daily
  • Adjunctive therapy of duodenal ulcers associated with Helicobacter pylori (in combination with antibiotic therapy either clarithromycin or clarithromycin and amoxicillin) in children:
  • 15 to 30 kg: 10 mg twice daily
  • Greater than 30 kg: 20 mg twice daily

How is Prilosec® (omeprazole) available?

Prilosec® is available in the following dosage forms and strengths:

  • Tablet

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Prilosec®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: November 14, 2017 | Last Modified: November 14, 2017

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