Premarin

By Medically reviewed by hellodoktor

Generic Name: Premarin Brand Name(s): Generics only. No brands available.

Uses

What is Premarin® (conjugated estrogens) used for?

Premarin® is used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body.

Premarin® is sometimes used as part of cancer treatment in women and men.

How should I take Premarin® (conjugated estrogens)?

Take Premarin® exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Premarin® may increase your risk of developing a condition that may lead to uterine cancer. Your doctor may prescribe a progestin to take while you are using Premarin®, to help lower this risk. Report any unusual vaginal bleeding right away.

Premarin® is sometimes taken on a daily basis. For certain conditions, the medicine is given in a cycle, such as 3 weeks on followed by 1 week off. Follow your doctor’s instructions.

If you see what looks like part of a Premarin® tablet in your stool, talk with your doctor.

Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis, and have regular mammograms.

If you need surgery or medical tests or if you will be on bed rest, you may need to stop using Premarin® for a short time. Any doctor or surgeon who treats you should know that you are using Premarin®.

How do I store Premarin® (conjugated estrogens)?

Premarin® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Premarin® in the bathroom or the freezer. There may be different brands of Premarin® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Premarin® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Premarin® (conjugated estrogens)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Premarin® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

You should not use Premarin® if you have:

  • A history of heart attack, stroke, or blood clot (especially in your lung or your lower body)
  • Abnormal vaginal bleeding that has not been checked by a doctor
  • Any type of breast, uterine, or hormone-dependent cancer
  • Liver disease
  • A bleeding or blood-clotting disorder
  • If you are pregnant or may become pregnant
  • If you have ever had an allergic reaction to estrogens

Premarin® will not prevent heart disease, heart attack, stroke, breast cancer, or dementia, and may actually increase your risk of developing these conditions. Long-term use may also increase your risk of breast cancer or blood clot. Talk with your doctor about your individual risks.

To make sure Premarin® is safe for you, tell your doctor if you have:

  • Unusual vaginal bleeding
  • Heart disease
  • Asthma
  • Epilepsy or other seizure disorder
  • Liver or kidney disease
  • Hereditary angioedema
  • Endometriosis
  • A thyroid disorder
  • Lupus
  • High levels of calcium in your blood (hypercalcemia)
  • Migraines
  • Gallbladder disease
  • Risk factors for coronary artery disease (such as diabetes, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, being older than 40, or if you have had a hysterectomy)

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Premarin® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Premarin®. Premarin® is pregnancy risk category X, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Premarin® (conjugated estrogens)?

Get emergency medical help if you have signs of an allergic reaction to Premarin®: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • Abnormal vaginal bleeding
  • A lump in your breast
  • Confusion, problems with memory or concentration
  • Heart attack symptoms – chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating
  • Liver problems – nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes)
  • Signs of a stroke – sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance
  • Signs of a blood clot in the lung – chest pain, sudden cough, wheezing, rapid breathing, coughing up blood
  • Signs of a blood clot in your leg – pain, swelling, warmth, or redness in one or both legs

Common side effects may include:

  • Breast pain or tenderness
  • Headache
  • Swelling in your hands or feet
  • Vaginal itching or discharge, changes in your menstrual periods, light vaginal bleeding or spotting
  • Hair loss
  • Nausea, vomiting, bloating, stomach cramps

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Premarin® (conjugated estrogens)?

Premarin® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Premarin® (conjugated estrogens)?

Premarin® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Premarin® (conjugated estrogens)?

Premarin® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Premarin® (conjugated estrogens).

What is the dose of Premarin® (conjugated estrogens) for an adult?

Treatment of Moderate to Severe Vasomotor Symptoms due to Menopause

Patients should be treated with the lowest effective dose. Generally, women should be started at 0.3 mg Premarin® daily. Subsequent dosage adjustment may be made based upon the individual patient response. This dose should be periodically reassessed by the healthcare provider.

Premarin® therapy may be given continuously, with no interruption in therapy, or in cyclical regimens (regimens such as 25 days on drug followed by 5 days off drug), as is medically appropriate on an individual basis.

Treatment of Moderate to Severe Symptoms of Vulvar and Vaginal Atrophy due to Menopause

Patients should be treated with the lowest effective dose. Generally, women should be started at 0.3 mg Premarin® daily. Subsequent dosage adjustment may be made based upon the individual patient response. This dose should be periodically reassessed by the healthcare provider.

Premarin® therapy may be given continuously, with no interruption in therapy, or in cyclical regimens (regimens such as 25 days on drug followed by 5 days off drug), as is medically appropriate on an individual basis.

Treatment of Hypoestrogenism due to Hypogonadism, Castration, or Primary Ovarian Failure

Premarin® therapy should be initiated and maintained with the lowest effective dose to achieve clinical goals. Female hypogonadism: 0.3 mg or 0.625 mg daily, administered cyclically (e.g., three weeks on and one week off).

Doses are adjusted depending on the severity of symptoms and responsiveness of the endometrium.

Female castration or primary ovarian failure: 1.25 mg daily, cyclically. Adjust dosage, upward or downward, according to severity of symptoms and response of the patient. For maintenance, adjust dosage to lowest level that will provide effective control.

Treatment of Breast Cancer (for Palliation Only) in Appropriately Selected Women and Men with Metastatic Disease

Suggested dosage is 10 mg three times daily, for a period of at least three months.

Treatment of Advanced Androgen-Dependent Carcinoma of the Prostate (for Palliation Only)

1.25 mg to 2 × 1.25 mg three times daily. The effectiveness of therapy can be judged by phosphatase determinations as well as by symptomatic improvement of the patient.

Prevention of Postmenopausal Osteoporosis

Premarin® therapy may be given continuously, with no interruption in therapy, or in cyclical regimens (regimens such as 25 days on drug followed by 5 days off drug), as is medically appropriate on an individual basis.

Patients should be treated with the lowest effective dose. Generally, women should be started at 0.3 mg Premarin® daily. Subsequent dosage adjustment may be made based upon the individual clinical and bone mineral density responses. This dose should be periodically reassessed by the healthcare provider.

What is the dose of Premarin® (conjugated estrogens) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Premarin® (conjugated estrogens) available?

Premarin® is available in the following dosage forms and strengths:

  • Tablet, film coated: estrogens, conjugated 0.45mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Premarin®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: August 21, 2017 | Last Modified: September 13, 2019

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