What is prednisolone?

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Generic Name: Prednisolone Brand Name(s): Generics only. No brands available.

Know the basics

What is prednisolone used for?

Prednisolone is a man-made form of a natural substance (corticosteroid hormone) made by the adrenal gland. It is used to treat conditions such as arthritis, blood problems, immune system disorders, skin and eye conditions, breathing problems, cancer, and severe allergies. It decreases your immune system’s response to various diseases to reduce symptoms such as pain, swelling and allergic-type reactions.

How should I take prednisolone?

Take prednisolone by mouth, with food or milk to prevent stomach upset, exactly as directed by your doctor. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

There are many brands, strengths, and forms of liquid prednisolone available. Read the dosing instructions carefully for each product because the amount of prednisolone may be different between products. See also Precautions and Storage sections.

Follow the dosing schedule carefully. The dosage and length of treatment are based on your medical condition and response to treatment. Your doctor may direct you to take prednisolone 1 to 4 times a day or take a single dose every other day. It may help to mark your calendar with reminders.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Your dose may need to be gradually decreased.

If you have used prednisolone regularly for a long time or in high doses, you may have withdrawal symptoms if the drug is suddenly stopped. To prevent withdrawal symptoms (such as weakness, weight loss, nausea, muscle pain, headache, tiredness, dizziness), your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details, and report any withdrawal reactions immediately. See also Precautions section.

Tell your doctor if your condition persists or worsens.

How do I store prednisolone?

Prednisolone is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store prednisolone in the bathroom or the freezer. There may be different brands of prednisolone that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush prednisolone down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Know the precautions & warnings

What should I know before using prednisolone?

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of prednisolone in children. However, pediatric patients are more likely to have slower growth and bone problems if prednisolone is used for a long time. Recommended doses should not be exceeded, and the patient should be carefully monitored during therapy.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of prednisolone in the elderly. However, elderly patients are more likely to have age-related kidney and bone problems, which may require caution and an adjustment in the dose for elderly patients receiving prednisolone.

Is it safe to take prednisolone during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Know the side effects

What are the side effects of prednisolone?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • Problems with your vision;
  • Swelling, rapid weight gain, feeling short of breath;
  • Severe depression, unusual thoughts or behavior, seizure (convulsions);
  • Bloody or tarry stools, coughing up blood;
  • Pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate);
  • Low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling); or
  • Dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Less serious side effects may include:

  • Sleep problems (insomnia), mood changes;
  • Acne, dry skin, thinning skin, bruising or discoloration;
  • Slow wound healing;
  • Increased sweating;
  • Headache, dizziness, spinning sensation;
  • Nausea, stomach pain, bloating; or
  • Changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Know the interactions

What drugs may interact with prednisolone?

Prednisolone may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Rotavirus Vaccine, Live.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aldesleukin, Aripiprazole, Asparaginase, Bupropion, Carbamazepine, Ceritinib, Cobicistat, Dabrafenib, Daclatasvir, Eliglustat, Elvitegravir, Eslicarbazepine Acetate, Idelalisib, Itraconazole, Mitotane, Nilotinib, Piperaquine, Pixantrone, Ritonavir, Siltuximab, Sorafenib.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alatrofloxacin, Alcuronium, Amobarbital, Aspirin, Atracurium, Balofloxacin, Cinoxacin, Ciprofloxacin, Clinafloxacin, Desogestrel, Dienogest, Drospirenone, Enoxacin, Estradiol Cypionate, Estradiol Valerate, Ethinyl Estradiol, Ethynodiol Diacetate, Etonogestrel, Fleroxacin, Flumequine, Fosphenytoin, Gallamine, Gemifloxacin, Grepafloxacin, Hexafluorenium, Levofloxacin, Levonorgestrel, Licorice, Lomefloxacin, Medroxyprogesterone Acetate, Mestranol, Metocurine, Moxifloxacin, Norelgestromin, Norethindrone, Norfloxacin, Norgestimate, Norgestrel, Ofloxacin, Pefloxacin, Phenytoin, Primidone, Prulifloxacin, Rifampin, Rosoxacin, Rufloxacin, Saiboku-To, Sparfloxacin, Temafloxacin, Tosufloxacin, Trovafloxacin Mesylate, Vecuronium.

Does food or alcohol interact with prednisolone?

Prednisolone may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with prednisolone?

Prednisolone may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • Cataracts;
  • Congestive heart failure;
  • Cushing’s syndrome (adrenal gland problem);
  • Diabetes;
  • Eye infection;
  • Glaucoma;
  • Hyperglycemia (high blood sugar);
  • Hypertension (high blood pressure);
  • Infection (e.g., bacterial, virus, or fungus);
  • Mood changes, including depression;
  • Myasthenia gravis (severe muscle weakness);
  • Osteoporosis (weak bones);
  • Peptic ulcer, active or history of;
  • Personality changes;
  • Stomach or intestinal problems (e.g., diverticulitis, ulcerative colitis);
  • Tuberculosis, inactive—Use with caution. May make these conditions worse.
  • Fungal infections;
  • Herpes simplex eye infection—Should not be used in patients with these conditions.
  • Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Understand the dosage

The information provided is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist before using this medication.

What is the dose of Prednisolone for an adult?

Usual Adult Dose for Multiple Sclerosis

Tablets and syrup for acute exacerbations: 200 mg daily for one week followed by 80 mg every other day for 1 month.

Usual Adult Dose for Bronchopulmonary Dysplasia

Tablets and syrup for acute exacerbations: 200 mg daily for one week followed by 80 mg every other day for 1 month.

Usual Adult Dose for Anti-inflammatory

Sodium phosphate:

Oral: 5 to 60 mg per day in divided doses 1 to 4 times/day.

Intravenous or Intramuscular: 4 to 60 mg/day

For intraarticular, intralesional or soft tissue administration:

Large joints: 10 to 20 mg

Small joints: 4 to 5 mg

Bursae: 10 to 15 mg

Tendon sheaths: 2 to 5 mg

Soft tissue infiltration: 10 to 30 mg

Ganglia: 5 to 10 mg

Injectable suspension (tebutate) for intraarticular, intralesional or soft tissue administration:

Large joints: 20 to 30 mg (doses > 40 mg not recommended)

Small joints: 8 to 10 mg

Bursae: 20 to 30 mg

Tendon sheaths: 4 to 10 mg

Ganglia: 10 to 20 mg

Injectable suspension (acetate) for intraarticular, intralesional or soft tissue administration: 4 to 100 mg

Bursae: 10 to 15 mg

Tendon sheaths: 2 to 5 mg

Soft tissue infiltration: 10 to 30 mg

What is the dose of Prednisolone for a child?

Usual Pediatric Dose for Immunosuppression

Oral: 0.1 to 2 mg/kg/day in divided doses 1 to 4 times a day.

Intravenous: 0.1 to 2 mg/kg/day in divided doses 1 to 4 times a day.

Usual Pediatric Dose for Asthma – Acute

Oral: 1 to 2 mg/kg/day in divided doses 1 to 2 times a day for 3 to 5 days.

Intravenous: 2 to 4 mg/kg/day divided 3 or 4 times a day.

Usual Pediatric Dose for Nephrotic Syndrome

First 3 episodes: Initial dose: 2 mg/kg/day (maximum dose 80 mg/day) until urine is free of protein for 3 consecutive days (maximum: 28 days); followed by 1 to 1.5 mg/kg/dose every other day for 4 weeks.

Frequent relapses or long-term maintenance dose: 0.5 to 1 mg/kg/dose given every other day for 3 to 6 months.

Usual Pediatric Dose for Bronchopulmonary Dysplasia

2 mg/kg/day orally divided twice daily for 5 days, followed by 1 mg/kg/day once daily for 3 days, followed by 1 mg/kg/dose every other day for 3 doses.

How is prednisolone available?

Prednisolone is available in the following dosage forms and strengths:

  • Suspension, oral: 15 mg/ 5 mL

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services (115) or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of prednisolone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: May 30, 2016 | Last Modified: January 4, 2017

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