Generic Name: Polysporin Brand Name(s): Generics only. No brands available.


What is Polysporin® (bacitracin and polymyxin B) used for?

Polysporin® is commonly used to avoid or treat skin infections.

How should I take Polysporin® (bacitracin and polymyxin B)?

Use Polysporin® as ordered by your doctor. Read all information given to you. Follow all instructions closely.

To gain the most benefit, do not miss doses.

Use as you have been told, even if your signs get better.

Do not take this medicine by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).

Clean affected part before use. Make sure to dry well.

Wash your hands before and after use. Do not wash your hands after use if putting this on your hand.

The treated part may be covered with a dressing.

Put a thin layer on the affected skin and rub in gently.

How do I store Polysporin® (bacitracin and polymyxin B)?

Polysporin® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Polysporin® in the bathroom or the freezer. There may be different brands of Polysporin® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Polysporin® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Polysporin® (bacitracin and polymyxin B)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Polysporin® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Tell all of your health care providers that you take Polysporin®. This includes your doctors, nurses, pharmacists, and dentists.

Do not use longer than you have been told. A second infection may happen.

Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine while you are pregnant.

Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using Polysporin® during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Polysporin®.

Side effects

What side effects can occur from Polysporin® (bacitracin and polymyxin B)?

Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Swelling.
  • Very bad skin irritation.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Polysporin® (bacitracin and polymyxin B)?

Polysporin® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Polysporin® (bacitracin and polymyxin B)?

Polysporin® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Polysporin® (bacitracin and polymyxin B)?

Polysporin® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Polysporin® (bacitracin and polymyxin B).

What is the dose of Polysporin® (bacitracin and polymyxin B) for an adult?

Consult your doctor for further information.

What is the dose of Polysporin® (bacitracin and polymyxin B) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Polysporin® (bacitracin and polymyxin B) available?

Polysporin® is available in the following dosage forms and strengths:

  • Ointment

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Polysporin®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: November 13, 2017 | Last Modified: November 13, 2017