Generic Name: Podophyllum resin Brand Name(s): Generics only. No brands available.

Uses

What is podophyllum resin used for?

Podophyllum resin is a cytotoxic agent. It works by preventing the growth of the wart tissue.

Podophyllum resin is commonly used for removing genital warts. It may also be used for other conditions as determined by your doctor.

How should I take podophyllum resin?

Podophyllum resin is usually administered at your doctor’s office, hospital, or clinic. If you are using podophyllum resin at home, carefully follow the procedures taught to you by your health care provider.

Thoroughly clean the affected area. Use the supplied applicator to apply the medicine sparingly to the wart. Avoid contact with healthy skin. Allow drying completely.

After the appropriate treatment time has elapsed, remove the dried medicine with alcohol or soap and water as directed by your doctor.

Ask your health care provider any questions you may have about how to use podophyllum resin.

How do I store podophyllum resin?

Podophyllum resin is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store podophyllum resin in the bathroom or the freezer. There may be different brands of podophyllum resin that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush podophyllum resin down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using podophyllum resin?

Podophyllum resin is for external use only. Do not get podophyllum resin in your eyes, nose, or mouth. If you get podophyllum resin in your eyes, rinse immediately with cool water.

Do not use podophyllum resin on bleeding warts, warts with hair growing from them, moles, or birthmarks.

Do not use podophyllum resin if the wart to be treated or the surrounding skin is inflamed or irritated.

Do not treat large areas or numerous warts at the same time.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using podophyllum resin during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking podophyllum resin. Podophyllum resin is pregnancy risk category X, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from podophyllum resin?

All medicines may cause side effects, but many people have no, or minor, side effects. When used in small doses, no common side effects have been reported with podophyllum resin. Seek medical attention right away if any of these severe side effects occur:

  • Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue)
  • Burning, tingling, or numbness of the skin, hands, legs, or feet
  • Diarrhea
  • Fever, chills, or persistent sore throat
  • Loss of consciousness
  • Nausea
  • Severe or persistent constipation
  • Unusual bruising or bleeding
  • Vomiting

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with podophyllum resin?

Podophyllum resin may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Especially, if you are taking steroids (e.g., prednisone) because they decrease podophyllum resin’s effectiveness.

Does food or alcohol interact with podophyllum resin?

Podophyllum resin may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with podophyllum resin?

Podophyllum resin may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using podophyllum resin.

What is the dose of podophyllum resin for an adult?

Condyloma Acuminata

Thoroughly cleanse the area.

Use supplied applicator to apply thoroughly to the lesion; allow to dry thoroughly; leave first application in contact for only a few minutes (30-40 min) to test for sensitivity.

Leave on subsequent applications for 1-4 hr depending on the condition of lesion and patient.

Protect adjacent normal skin with petrolatum.

Remove dried podophyllum resin thoroughly with alcohol or soap and water after treatment time has elapsed.

What is the dose of podophyllum resin for a child?

Condyloma Acuminata

Thoroughly cleanse the area.

Use supplied applicator to apply thoroughly to the lesion; allow to dry thoroughly; leave first application in contact for only a few minutes (30-40 min) to test for sensitivity.

Leave on subsequent applications for 1-4 hr depending on the condition of lesion and patient.

Protect adjacent normal skin with petrolatum.

Remove dried podophyllum resin thoroughly with alcohol or soap and water after treatment time has elapsed.

How is podophyllum resin available?

Podophyllum resin is available in the following dosage forms and strengths:

  • Podophyllum resin solution 25%

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of podophyllum resin, contact your doctor immediately.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: March 24, 2017 | Last Modified: March 24, 2017

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