Generic Name: Pitavastatin Brand Name(s): Generics only. No brands available.

Uses

What is Pitavastatin used for?

Pitavastatin is used along with a proper diet to help lower “bad” cholesterol and fats (such as LDL, triglycerides) and raise “good” cholesterol (HDL) in the blood. It belongs to a group of drugs known as “statins.” It works by reducing the amount of cholesterol made by the liver. Lowering “bad” cholesterol and triglycerides and raising “good” cholesterol decreases the risk of heart disease and helps prevent strokes and heart attacks.

In addition to eating a proper diet (such as a low-cholesterol/low-fat diet), other lifestyle changes that may help this medication work better include exercising, losing weight if overweight, and stopping smoking. Consult your doctor for more details.

How should I take Pitavastatin?

Take this medication by mouth with or without food as directed by your doctor, usually once daily.

Dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

If you also take certain other drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol), take pitavastatin at least 1 hour before or at least 4 hours after taking these medications. These products can react with pitavastatin, preventing its full absorption.

Take this medication regularly in order to get the most benefit from it. Remember to take it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with high cholesterol or triglycerides do not feel sick.

It is very important to continue to follow your doctor’s advice about diet and exercise. It may take up to 4 weeks before you get the full benefit of this drug.

How do I store Pitavastatin?

Pitavastatin is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Pitavastatin in the bathroom or the freezer. There may be different brands of Pitavastatin that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Pitavastatin down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Pitavastatin?

Before taking pitavastatin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, alcohol use.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Limit alcoholic beverages. Daily use of alcohol may increase your risk for liver problems, especially when combined with pitavastatin. Ask your doctor or pharmacist for more information.

Older adults may be more sensitive to the side effects of this drug, especially muscle problems.

This medication must not be used during pregnancy. Pitavastatin may harm an unborn baby. Therefore, it is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control (such as condoms, birth control pills) while taking this medication. If you become pregnant or think you may be pregnant, tell your doctor right away. Discuss with your doctor when you should stop pitavastatin if you are trying to become pregnant.

It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Pitavastatin during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Pitavastatin. Pitavastatin is pregnancy risk category X according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Pitavastatin?

A very small number of people taking pitavastatin may have mild memory problems or confusion. If these rare effects occur, talk to your doctor.

Rarely, statins may cause or worsen diabetes. Talk to your doctor about the benefits and risks.

This drug may rarely cause muscle problems (which can rarely lead to very serious conditions called rhabdomyolysis and autoimmune myopathy). Tell your doctor right away if you develop any of these symptoms during treatment and if these symptoms persist after your doctor stops this drug: muscle pain/tenderness/weakness (especially with fever or unusual tiredness), signs of kidney problems (such as change in the amount of urine).

This medication may rarely cause liver problems. If you notice any of the following serious side effects, tell your doctor right away: stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin, dark urine.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Pitavastatin?

Some products that may interact with this drug include: colchicine, gemfibrozil.

Other medications can affect the removal of pitavastatin from your body, which may affect how pitavastatin works. Examples include cyclosporine, letermovir, macrolide antibiotics (such as erythromycin), rifamycins (such as rifampin), sofosbuvir/velpatasvir/voxilaprevir, among others.

Pitavastatin may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Pitavastatin?

Pitavastatin may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

Do not take any red yeast rice products while you are taking pitavastatin because some red yeast rice products may also contain a statin called lovastatin. Taking pitavastatin and red yeast rice products together can increase your risk of serious muscle and liver problems.

What health conditions may interact with Pitavastatin?

Pitavastatin may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Pitavastatin.

What is the dose of Pitavastatin for an adult?

Usual Adult Dose for Hyperlipidemia

Initial dose: 2 mg orally once a day

Maintenance dose: 1 mg to 4 mg orally once a day

Maximum dose: 4 mg/day

Comments:

-Doses greater than 4 mg once a day have been associated with an increased risk for severe myopathy in premarketing studies and thus doses should not exceed 4 mg/day.

Use: As an adjunct to diet to reduce total cholesterol, low density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), and triglycerides, and to increase high density lipoprotein cholesterol (HDL-C) in patients with primary hyperlipidemia or mixed dyslipidemia

Usual Adult Dose for Dyslipidemia

Initial dose: 2 mg orally once a day

Maintenance dose: 1 mg to 4 mg orally once a day

Maximum dose: 4 mg/day

Comments:

-Doses greater than 4 mg once a day have been associated with an increased risk for severe myopathy in premarketing studies and thus doses should not exceed 4 mg/day.

Use: As an adjunct to diet to reduce total cholesterol, low density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), and triglycerides, and to increase high density lipoprotein cholesterol (HDL-C) in patients with primary hyperlipidemia or mixed dyslipidemia

Renal Dose Adjustments

Moderate to severe renal dysfunction (not receiving hemodialysis [GFR 15 to 59 mL/min/1.73 m2]):

-Initial dose: 1 mg orally once a day

-Maximum dose: 2 mg orally once a day

Liver Dose Adjustments

Active liver disease (including unexplained persistent elevations in hepatic transaminase levels): Contraindicated

Dose Adjustments

Concomitant use with erythromycin:

-Maximum dose: 1 mg orally once a day

Concomitant use with rifampin:

-Maximum dose: 2 mg orally once a day

Dialysis

ESRD receiving hemodialysis:

-Initial dose: 1 mg orally once a day

-Maximum dose: 2 mg orally once a day

Other Comments

Administration advice:

-Take orally once a day, at any time of day, with or without food

Storage requirements:

-Protect from light.

General:

-This drug has not been studied in Fredrickson Type I, III, and V dyslipidemias.

-Dosages should be individualized according to patient characteristics, including goals of therapy and response to therapy.

-This drug should be used in addition to a diet restricted in saturated fat and cholesterol and only when response to diet and other nonpharmacologic measures alone has been inadequate.

Monitoring:

-Hepatic: Measure liver enzymes prior to initiating therapy and repeat if signs/symptoms of liver injury occur.

-Metabolic: Following initiation or upon titration, lipid levels should be measured after 4 weeks and the dose adjusted accordingly.

Patient advice:

-Report immediately any unexplained muscle pain, tenderness, or weakness, especially if accompanied by malaise or fever, or if muscle signs/symptoms persist after discontinuing therapy.

-Promptly report any symptoms that may be indicative of liver injury, including fatigue, anorexia, right upper abdominal discomfort, dark urine, or jaundice.

-Contraceptive methods should be used while taking this drug.

-Talk to your health care provider if you are pregnant, planning to become pregnant, or breastfeeding; this drug is not recommended for use during pregnancy or in nursing mothers.

What is the dose of Pitavastatin for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Pitavastatin available?

Pitavastatin is available in the following dosage forms and strengths:

  • Oral tablet.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Pitavastatin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

 

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: April 20, 2018 | Last Modified: April 20, 2018