Generic Name: Phenobarb + Hyoscy + Atropine + Scop Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: D

Uses

What is Phenobarb + Hyoscy + Atropine + Scop used for?

This product contains several medications: belladonna alkaloids (made up of the drugs hyoscyamine, atropine, and scopolamine) and phenobarbital. Belladonna alkaloids help to reduce the symptoms of stomach and intestinal cramping. They work by slowing the natural movements of the gut and by relaxing the muscles in the stomach and intestines. Belladonna alkaloids belong to a class of drugs known as anticholinergics/antispasmodics. Phenobarbital helps to reduce anxiety. It acts on the brain to produce a calming effect. Phenobarbital belongs to a class of drugs known as barbiturate sedatives.

How should I take Phenobarb + Hyoscy + Atropine + Scop?

Take this medication by mouth as directed by your doctor. If you are taking the immediate-release tablets or liquid form of this medication, take it usually 3 to 4 times a day or as directed by your doctor.

If you are using the liquid, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

If you are taking the extended-release tablets, take them usually every 12 hours or as directed by your doctor. Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

Antacids lower the absorption of this medication. If you are taking an antacid, take it at least 2 hours apart from this medication.

The dosage is based on your medical condition and response to treatment. In children, the dosage is also based on weight.

Do not increase your dose or take this drug more often without your doctor’s approval. Your condition will not improve any faster and the risk of serious side effects may increase.

This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. In such cases, withdrawal symptoms (such as anxiety, muscle twitching, shakiness, dizziness, worsening weakness, nausea, vomiting) may occur if you suddenly stop using this medication. Withdrawal from the phenobarbital can be severe and include seizures and (rarely) death. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details, and report any withdrawal reactions right away.

When this medication is used for a long time, it may not work as well. Your doctor may need to increase your dose or change your medication. Talk with your doctor if this medication stops working well.

Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details.

Tell your doctor if your condition persists or worsens.

How do I store Phenobarb + Hyoscy + Atropine + Scop?

Phenobarb + Hyoscy + Atropine + Scop is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Phenobarb + Hyoscy + Atropine + Scop in the bathroom or the freezer. There may be different brands of Phenobarb + Hyoscy + Atropine + Scop that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Phenobarb + Hyoscy + Atropine + Scop down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Phenobarb + Hyoscy + Atropine + Scop?

Before taking this medication, tell your doctor or pharmacist if you are allergic to hyoscyamine, atropine, scopolamine, or phenobarbital; or to primidone; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: personal or family history of glaucoma (angle-closure type), problems with urination (due to enlarged prostate, a blocked urinary tract), other stomach/intestinal problems (such as slow gut, blockage, ulcerative colitis, infection, little/no stomach acid, ileostomy/colostomy patients with diarrhea), overactive thyroid, heart problems (such as coronary artery disease, angina, congestive heart failure, fast/irregular heartbeat, heart problems due to severe bleeding), high blood pressure, heartburn problems (such as acid reflux, hiatal hernia, esophagus problems), certain nervous system problem (autonomic neuropathy), myasthenia gravis, liver problems, kidney problems, a certain blood disorder (porphyria), restlessness or excitement during past use of phenobarbital, breathing/lung problems, personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), mental/mood conditions (such as depression, thoughts of suicide, psychosis).

This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana.

The liquid form of this product may contain alcohol or sugar. Caution is advised if you have diabetes, alcohol dependence, liver disease, or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely.

This medication may make you sweat less, making you more likely to get heat stroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest. Get medical help right away if you have a fever that does not go away, mental/mood changes, headache, or dizziness.

Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, unusual excitement, constipation, and urination problems. Drowsiness and confusion can increase the risk of falling.

Children may be more sensitive to the side effects of this drug. This drug can often cause excitement instead of drowsiness in young children.

This medication is not recommended for use during pregnancy. It may harm an unborn baby. Consult your doctor for details. Hormonal birth control products (such as pills, patch, ring) may not be effective if taken with this medication. Discuss reliable forms of birth control with your doctor.

This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Phenobarb + Hyoscy + Atropine + Scop during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Phenobarb + Hyoscy + Atropine + Scop. Phenobarb + Hyoscy + Atropine + Scop is pregnancy risk category D according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Phenobarb + Hyoscy + Atropine + Scop?

Dizziness, drowsiness, weakness, blurred vision, dry eyes, dry mouth, nausea, constipation, and abdominal bloating may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute. To relieve dry eyes, consult your pharmacist for artificial tears or other eye lubricants.

To prevent constipation, eat a diet adequate in fiber, drink plenty of water, and exercise. Consult your pharmacist for help in selecting a laxative (such as a stimulant type with stool softener).

Tell your doctor right away if you have any serious side effects, including: decreased sweating, dry/hot/flushed skin, fast/irregular heartbeat, loss of coordination, slurred speech, fainting, mental/mood changes (such as confusion, agitation, unusual excitement, depression, rare thoughts of suicide), difficulty urinating, decreased sexual ability, signs of anemia (such as unusual tiredness, pale skin), signs of infection (such as fever, persistent sore throat), easy bruising/bleeding.

Get medical help right away if you have any very serious side effects, including: eye pain/swelling/redness, vision changes (such as seeing rainbows around lights at night), slow/shallow breathing.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Phenobarb + Hyoscy + Atropine + Scop?

Some products that may interact with this drug include: darunavir, etravirine, potassium tablets/capsules, rilpivirine, sodium oxybate, drugs that are affected by slowed gut movement (such as pramlintide).

This medication may affect the absorption of other products such as griseofulvin, certain azole anti-fungal drugs (ketoconazole, itraconazole), slowly dissolving forms of digoxin, among others.

Other medications can affect the removal of phenobarbital from your body, which may affect how this product works. Examples include St. John’s wort, among others.

Phenobarbital can speed up the removal of other medications from your body, which may affect how they work. Examples of affected drugs include artemether/lumefantrine, asunaprevir, atazanavir, boceprevir, cobicistat, lurasidone, ranolazine, sofosbuvir, sorafenib, voriconazole, certain calcium channel blockers such as felodipine/nimodipine, among others.

This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use reliable backup birth control methods while using this medication. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well.

The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also cause drowsiness or breathing problems. Tell your doctor or pharmacist if you are taking other products such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana, other drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).

Check the labels on all your medicines (such as allergy or cough-and-cold products, diet aids) because they may contain ingredients that cause drowsiness or a fast heartbeat. Ask your pharmacist about using those products safely.

This medication may interfere with certain laboratory tests (including gastric secretion tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Phenobarbital is very similar to primidone. Do not use medications containing primidone while using phenobarbital.

Phenobarb + Hyoscy + Atropine + Scop may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Phenobarb + Hyoscy + Atropine + Scop?

Phenobarb + Hyoscy + Atropine + Scop may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Phenobarb + Hyoscy + Atropine + Scop?

Phenobarb + Hyoscy + Atropine + Scop may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Phenobarb + Hyoscy + Atropine + Scop.

What is the dose of Phenobarb + Hyoscy + Atropine + Scop for an adult?

Usual Adult Dose for Duodenal Ulcer

Elixir: 1 or 2 teaspoonfuls orally 3 or 4 times a day according to severity of symptoms

Regular Release Tablets: 1 or 2 tablets orally 3 or 4 times a day according to severity of symptoms

Extended release tablets: 1 tablet orally every 12 hours

-If indicated, 1 tablet orally every 8 hours

Comments:

-Adjust dose to patient needs to assure symptomatic control with minimum adverse effects.

Usual Adult Dose for Irritable Bowel Syndrome

Elixir: 1 or 2 teaspoonfuls orally 3 or 4 times a day according to severity of symptoms

Regular Release Tablets: 1 or 2 tablets orally 3 or 4 times a day according to severity of symptoms

Extended release tablets: 1 tablet orally every 12 hours

-If indicated, 1 tablet orally every 8 hours

Comments:

-Adjust dose to patient needs to assure symptomatic control with minimum adverse effects.

Usual Adult Dose for Enterocolitis

Elixir: 1 or 2 teaspoonfuls orally 3 or 4 times a day according to severity of symptoms

Regular Release Tablets: 1 or 2 tablets orally 3 or 4 times a day according to severity of symptoms

Extended release tablets: 1 tablet orally every 12 hours

-If indicated, 1 tablet orally every 8 hours

Comments:

-Adjust dose to patient needs to assure symptomatic control with minimum adverse effects.

Renal Dose Adjustments

Use with caution.

Liver Dose Adjustments

Use with caution.

-Barbiturates are hepatically metabolized, so initial doses should be small in patients with hepatic dysfunction.

What is the dose of Phenobarb + Hyoscy + Atropine + Scop for a child?

Usual Pediatric Dose for Duodenal Ulcer

Elixir:

Initial oral dose by weight:

4.5 kg: 0.5 mL every 4 hours OR 0.75 mL every 6 hours

9.1 kg: 1 mL every 4 hours OR 1.5 mL every 6 hours

13.6 kg: 1.5 mL every 4 hours OR 2 mL every 6 hours

22.7 kg: 2.5 mL every 4 hours OR 3.75 mL every 6 hours

34 kg: 3.75 mL every 4 hours OR 5 mL every 6 hours

45.4 kg: 5 mL every 4 hours OR 7.5 mL every 6 hours

Comments:

-Adjust dose to patient needs to assure symptomatic control with minimum adverse effects.

-Use a pediatric dosing device or oral syringe to measure the dose.

Usual Pediatric Dose for Irritable Bowel Syndrome

Elixir:

Initial oral dose by weight:

4.5 kg: 0.5 mL every 4 hours OR 0.75 mL every 6 hours

9.1 kg: 1 mL every 4 hours OR 1.5 mL every 6 hours

13.6 kg: 1.5 mL every 4 hours OR 2 mL every 6 hours

22.7 kg: 2.5 mL every 4 hours OR 3.75 mL every 6 hours

34 kg: 3.75 mL every 4 hours OR 5 mL every 6 hours

45.4 kg: 5 mL every 4 hours OR 7.5 mL every 6 hours

Comments:

-Adjust dose to patient needs to assure symptomatic control with minimum adverse effects.

-Use a pediatric dosing device or oral syringe to measure the dose.

Usual Pediatric Dose for Enterocolitis

Elixir:

Initial oral dose by weight:

4.5 kg: 0.5 mL every 4 hours OR 0.75 mL every 6 hours

9.1 kg: 1 mL every 4 hours OR 1.5 mL every 6 hours

13.6 kg: 1.5 mL every 4 hours OR 2 mL every 6 hours

22.7 kg: 2.5 mL every 4 hours OR 3.75 mL every 6 hours

34 kg: 3.75 mL every 4 hours OR 5 mL every 6 hours

45.4 kg: 5 mL every 4 hours OR 7.5 mL every 6 hours

Comments:

-Adjust dose to patient needs to assure symptomatic control with minimum adverse effects.

-Use a pediatric dosing device or oral syringe to measure the dose.

How is Phenobarb + Hyoscy + Atropine + Scop available?

Phenobarb + Hyoscy + Atropine + Scop is available in the following dosage forms and strengths:

  • Oral capsule,
  • Oral elixir,
  • Oral tablet, extended release,
  • Oral tablet, oral liquid.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Phenobarb + Hyoscy + Atropine + Scop, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

 

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: September 1, 2018 | Last Modified: September 1, 2018

Want to live your best life?
Get the Hello Doktor Daily newsletter for health tips, wellness updates and more.