Phenergan

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Generic Name: Phenergan Brand Name(s): Generics only. No brands available.

Uses

What is Phenergan® (promethazine) used for?

Phenergan® is commonly used for preventing and treating nausea and vomiting connected with certain conditions such as before/after surgery, motion sickness.

It is also used to treat allergy symptoms such as rash, itching, and runny nose, hives, watery eyes. It may be used to help you feel sleepy, relaxed before and after surgery or to help certain narcotic pain relievers (such as meperidine) work better.

It may also be used for a short time to treat a runny nose due to the common cold.

Phenergan® is not used to treat symptoms of asthma, pneumonia, or other lower respiratory tract infections.

How should I take Phenergan® (promethazine)?

Take Phenergan® by mouth with or without food as exactly prescribed and directed by your doctor, usually 2 to 4 times daily.

For motion sickness, the first dose of Phenergan® should be taken 30 to 60 minutes before beginning travel.

For allergies, this medication may be taken once daily at bedtime to avoid being drowsy during the day.

When used before surgery, Phenergan® may be taken the night before or just before the procedure and may be continued afterwards as directed.

How often you take Phenergan® and the timing of your dose will rely on the condition you are treating.

How do I store Phenergan® (promethazine)?

Phenergan® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Phenergan® in the bathroom or the freezer. There may be different brands of Phenergan® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Phenergan® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Phenergan® (promethazine)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Phenergan® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Phenergan® should not be given to a child younger than 2 years old. Phenergan® can cause severe breathing problems or death in very young children. Carefully follow your doctor’s instructions when giving this medicine to a child of any age.

You should not take Phenergan® if you are allergic to promethazine or to similar medicines such as chlorpromazine, fluphenazine, mesoridazine, perphenazine, prochlorperazine, thioridazine, or trifluperazine.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Phenergan® (promethazine)?

Common side effects may include:

  • Drowsiness, dizziness
  • Constipation
  • Ringing in your ears
  • Double vision
  • Feeling nervous
  • Dry mouth
  • Tired feeling, sleep problems (insomnia)

Stop using Phenergan® and call your doctor at once if you have:

  • Severe drowsiness, weak or shallow breathing
  • A light-headed feeling, like you might pass out
  • Confusion, agitation, hallucinations, nightmares
  • Seizure (convulsions)
  • Fast or slow heartbeats
  • Jaundice (yellowing of the skin or eyes)
  • Uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement)
  • Easy bruising or bleeding (nosebleeds, bleeding gums)
  • Sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing; or
  • Severe nervous system reaction–very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out

Side effects such as confusion and severe drowsiness may be more likely in older adults.

Get emergency medical help if you have any signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Phenergan® (promethazine)?

Phenergan® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are: antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray), metoclopramide.

Does food or alcohol interact with Phenergan® (promethazine)?

Phenergan® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Phenergan® (promethazine)?

Phenergan® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Health conditions that may interact with this drug are:

  • Anticholinergic Effects
  • Acute Alcohol Intoxication
  • Cardiovascular Disease
  • CNS Depression
  • Head Injury
  • Antidopaminergic Effects 1
  • Asthma
  • Asthma/COPD
  • Breast Cancer
  • Dystonic Reactions
  • Hematologic Toxicity
  • Liver Disease
  • NMS
  • Parkinsonism
  • Renal Dysfunction
  • Respiratory Disorders
  • Seizure Disorders
  • Tardive Dyskinesia
  • Antidopaminergic Effects 2

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of Phenergan® (promethazine) for an adult?

For Anaphylaxis:

Parenteral: 25 mg IV or IM once, followed by close observation for response. This dose may be repeated within 2 hours if needed. Oral therapy should be started as soon as feasible if continued medication is required.

Oral: 25 mg orally once. This dose may be repeated every 4 hours as needed.

Rectal: 25 mg administered rectally once. This dose may be repeated every 4 hours as needed.

For Allergic Reaction:

Oral or rectal: 12.5 mg before meals and 25 mg at bedtime, if necessary. Alternatively, a single 25 mg dose given at bedtime or 6.25 mg to 12.5 mg three times daily.

IM or IV: 25 mg, may repeat in 2 hours if necessary.

For Allergic Rhinitis:

Parenteral: 25 mg IV or IM, followed by close observation for response. This dose may be repeated within 2 hours if needed. Oral therapy should be started as soon as feasible if continued medication is required.

Oral: 25 mg at bedtime. Alternatively, 12.5 mg may be administered before the evening meal and again at bedtime for antihistamine effects.

Rectal: 25 mg at bedtime. Alternatively, 12.5 mg may be administered before the evening meal and again at bedtime for antihistamine effects.

For Light Sedation:

Parenteral: 25 mg IV or IM once, followed by close observation for response. An additional dose, up to 50 mg, may be administered to achieve the desired clinical effect.

Oral: 25 mg once. An additional dose, up to 50 mg, may be administered to achieve the desired clinical effect.

Rectal: 25 mg once. An additional dose, up to 50 mg, may be administered to achieve the desired clinical effect.

For Motion Sickness:

Oral or rectal: 25 mg 30 to 60 minutes before departure, then every 12 hours as needed.

Usual Adult Dose for Nausea/Vomiting:

Oral, rectal, IM or IV: 12.5 to 25 mg every 4 to 6 hours as needed.

For Opiate Adjunct:

Oral, rectal, IM or IV: 25 to 50 mg every 4 hours as needed to augment the effects of concomitantly administered opioids.

For Urticaria:

Parenteral: 25 mg IV or IM, followed by close observation for response. This dose may be repeated within 2 hours if needed. Oral therapy should be started as soon as feasible if continued medication is required.

Oral: 25 mg at bedtime. Alternatively, 12.5 mg may be administered before the evening meal and again at bedtime for antihistamine effects.

Rectal: 25 mg at bedtime. Alternatively, 12.5 mg may be administered before the evening meal and again at bedtime for antihistamine effects.

For Sedation:

Oral, rectal, IM or IV: 25 to 50 mg/dose.

For Vertigo:

Acute Vertigo:

Initial: 25 mg IM, IV, orally, or by suppository.

Maintenance: 12.5 to 50 mg every 4 to 8 hours.

Maximum daily dose should not exceed 75 mg.

What is the dose of Phenergan® (promethazine) for a child?

For Allergic Reaction:

Greater than or equal to 2 years: oral or rectal: 0.1 mg/kg/dose every 6 hours during the day and 0.5 mg/kg/dose at bedtime as needed.

For Motion Sickness:

Greater than or equal to 2 years: Oral or rectal: 0.5 mg/kg (not to exceed 25 mg) 30 minutes to 1 hour before departure, then every 12 hours as needed.

For Nausea or Vomiting:

Greater than or equal to 2 years: oral, rectal, IM or IV: 0.25 to 1 mg/kg/dose (not to exceed 25 mg) 4 to 6 times a day as needed.

For Sedation:

Greater than or equal to 2 years: Sedation: oral, IM, IV, or rectal: 0.5 to 1 mg/kg/dose (not to exceed 25 mg) every 6 hours as needed.

Phenergan® dosage should not exceed half of suggested adult dosage.

How is Phenergan® (promethazine) available?

Phenergan® is available in the following dosage forms and strengths:

  • Tablets and Suppositories: promethazine hydrochloride
  • Injection: promethazine hydrochloride 25mg in 1Ml
  • Rectal suppository: promethazine Hydrochloride 50mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Phenergan®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: September 2, 2017 | Last Modified: September 2, 2017

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