Peramivir

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Generic Name: Peramivir Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: N

Uses

What is Peramivir used for?

Peramivir is used to treat symptoms caused by the flu virus (influenza) if you have had symptoms for 2 days or less. It helps make the symptoms (such as stuffy nose, cough, sore throat, fever/chills, aches, tiredness) less severe and shortens the recovery time by about 1 to 2 days.

This medication works by stopping the flu virus from growing. It is not a substitute for the flu vaccine.

How should I take Peramivir?

This medication is given as a single dose as directed by your doctor. It is given slowly into a vein, usually over 15 to 30 minutes. The dosage is based on your medical condition, age, and response to treatment. Children’s dosage is also based on weight.

Tell your doctor if your condition persists or worsens, or if new symptoms appear.

How do I store Peramivir?

Store intact vials in original carton at 20°C to 25°C (68°F to 77°F); excursions are permitted between 15°C and 30°C (59°F and 86°F). After dilution, administer immediately or store at 2°C to 8°C (36°F to 46°F) for up to 24 hours. Discard unused diluted solution after 24 hours.

There may be different brands of Peramivir that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Peramivir down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Peramivir?

Before using peramivir, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease (including dialysis treatment).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Peramivir during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Peramivir. Peramivir is pregnancy risk category N according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Peramivir?

The flu itself or peramivir may rarely cause serious mental/mood changes. This may be more likely in children. Tell your doctor right away of any signs of unusual behavior, including: confusion, hallucinations, agitation, self-injury.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Peramivir?

Tell your doctor if you have received flu vaccine in the nose within 2 weeks before treatment with this medication. This medication may lower your protection from flu vaccine given in the nose. Wait at least 2 days after ending treatment with this medication before receiving flu vaccine given in the nose.

Peramivir may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Peramivir?

Peramivir may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Peramivir?

Peramivir may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Peramivir.

What is the dose of Peramivir for an adult?

Usual Adult Dose for Influenza

600 mg IV once as a single dose

Use: For the treatment of acute uncomplicated influenza in patients symptomatic no more than 2 days

Renal Dose Adjustments

Adults and adolescents (13 years or older):

-CrCl at least 50 mL/min: No adjustment recommended.

-CrCl 30 to 49 mL/min: 200 mg IV once

-CrCl 10 to 29 mL/min: 100 mg IV once

Dialysis

Hemodialysis: Dose should be adjusted based on renal function and administered after dialysis.

Other Comments

Administration advice:

-Administer within 2 days of onset of influenza symptoms.

-Administer via IV infusion for 15 to 30 minutes.

-If diluted solution is refrigerated, allow it to reach room temperature then administer at once; discard unused diluted solution after 24 hours.

Reconstitution/preparation techniques:

-This drug must be diluted before infusion.

-The manufacturer product information should be consulted.

IV compatibility:

-Compatible: 0.9% or 0.45% sodium chloride, 5% dextrose, lactated Ringers; materials commonly used for administration (e.g., polyvinylchloride [PVC] bags, PVC-free bags, polypropylene syringes, polyethylene tubing)

-Do not mix or co-infuse with other IV agents.

General (limitations of use):

-Efficacy based on clinical trials of naturally-occurring influenza in which the infections were mostly due to influenza A virus; limited number enrolled who were infected with influenza B virus.

-As influenza viruses change over time, resistant or more virulent mutations may emerge and decrease the efficacy of antiviral drugs; available influenza drug susceptibility patterns and treatment effects should be considered when deciding whether to use this drug.

-Efficacy not established in patients with serious influenza requiring hospitalization.

Patient advice:

-Seek medical attention at once if an allergic-like reaction occurs/is suspected.

-After receiving this drug, contact physician if signs of abnormal behavior occur.

What is the dose of Peramivir for a child?

Usual Pediatric Dose for Influenza

2 to 12 years: 12 mg/kg IV once as a single dose

-Maximum dose: 600 mg/dose

13 years or older: 600 mg IV once as a single dose

Use: For the treatment of acute uncomplicated influenza in patients symptomatic no more than 2 days

Renal Dose Adjustments

Pediatric patients (2 to 12 years):

-CrCl at least 50 mL/min: No adjustment recommended.

-CrCl 30 to 49 mL/min: 4 mg/kg IV once

-CrCl 10 to 29 mL/min: 2 mg/kg IV once

Comments:

-The manufacturer product information should be consulted regarding maximum dose in pediatric patients (2 to 12 years).

Precautions

Safety and efficacy have not been established in patients younger than 2 years.

How is Peramivir available?

Peramivir is available in the following dosage forms and strengths:

  • Intravenous solution.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Peramivir, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: August 10, 2018 | Last Modified: August 10, 2018

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