Pentosan polysulfate sodium

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Generic Name: Pentosan polysulfate sodium Brand Name(s): Generics only. No brands available.

Uses

What is Pentosan polysulfate sodium used for?

Pentosan polysulfate sodium is used to treat pain/discomfort from a certain bladder disorder (interstitial cystitis). It may work by forming a layer on the bladder wall and protecting it from harmful/irritating substances in the urine. It is also a weak “blood thinner” and therefore may increase the risk of bruising/bleeding (e.g., bleeding from the nose/gums).

How should I take Pentosan polysulfate sodium?

Take this medication by mouth at least 1 hour before or 2 hours after meals, usually 3 times daily or as directed by your doctor.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Do not increase your dose or take this medication more often than prescribed. Your condition will not improve any faster, and the risk of serious side effects may be increased.

Inform your doctor if your condition worsens or does not improve after 3 months.

How do I store Pentosan polysulfate sodium?

Pentosan polysulfate sodium is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Pentosan polysulfate sodium in the bathroom or the freezer. There may be different brands of Pentosan polysulfate sodium that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Pentosan polysulfate sodium down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Pentosan polysulfate sodium?

Before taking pentosan polysulfate sodium, tell your doctor or pharmacist if you are allergic to it; or to heparin or low molecular weight heparin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding disorders (e.g., hemophilia, thrombocytopenia), blood vessel disorders (e.g., aneurysm), liver disease, spleen disorders, stomach/intestinal disorders (e.g., stomach ulcers, polyps, diverticula).

Before having surgery, tell your doctor or dentist that you are using this medication.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Pentosan polysulfate sodium during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Pentosan polysulfate sodium. Pentosan polysulfate sodium is pregnancy risk category B according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Pentosan polysulfate sodium?

Diarrhea, hair loss, nausea, headache, stomach upset, or abdominal pain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: unusual bruising/bleeding (e.g., blood in stool), mental/mood changes, heartburn, discomfort when swallowing.

Tell your doctor right away if any of these rare but very serious side effects occur: tiredness, fast/pounding heartbeat, signs of infection (e.g., fever, persistent sore throat), shortness of breath, vision changes, eye pain, dark urine, yellowing eyes/skin, persistent nausea/vomiting.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Pentosan polysulfate sodium?

This drug should not be used with the following medication because very serious interactions may occur: mifepristone.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: “blood thinners” (e.g., warfarin, heparin, tenecteplase, abciximab, clopidogrel, ticlopidine), sulfinpyrazone.

Check all prescription and nonprescription medicine labels carefully since many contain pain relievers/fever reducers (NSAIDs such as aspirin, ibuprofen, naproxen, ketorolac) that may increase your risk for side effects if taken together with this medication. Low-dose aspirin should be continued if prescribed by your doctor for specific medical reasons such as heart attack or stroke prevention (usually at dosages of 81-325 milligrams per day). Ask your doctor or pharmacist for more details.

This medication may interfere with certain laboratory tests (including prothrombin time/INR, factor Xa levels), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Pentosan polysulfate sodium may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Pentosan polysulfate sodium?

Pentosan polysulfate sodium may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Pentosan polysulfate sodium?

Pentosan polysulfate sodium may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Pentosan polysulfate sodium.

What is the dose of Pentosan polysulfate sodium for an adult?

Usual Adult Dose for Cystitis

100 mg orally 3 times a day, taken with water at least 1 hour before or 2 hours after meals.

Liver Dose Adjustments

Caution should be exercised when using pentosan polysulfate sodium in patients with hepatic insufficiency.

Dose Adjustments

Therapy assessment should be conducted at the end of 3 months of treatment. Therapy may be continued for another 3 months if no improvement was achieved and if limited adverse effects are not present.

Other Comments

Patients should be reassessed at 3 and 6 months for adverse effects and/or signs of improvement. Patients not responding within 6 months were not continued during clinical trials.

What is the dose of Pentosan polysulfate sodium for a child?

Precautions

Safety and effectiveness have not been established in pediatric patients less than 16 years of age.

How is Pentosan polysulfate sodium available?

Pentosan polysulfate sodium is available in the following dosage forms and strengths:

  • Oral capsule

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Pentosan polysulfate sodium, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: April 11, 2018 | Last Modified: April 11, 2018

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