Paromomycin

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Generic Name: Paromomycin Brand Name(s): Generics only. No brands available.

Uses

What is Paromomycin used for?

Paromomycin is used to treat a certain parasite infection of the intestines (amebiasis). This medication is known as an aminoglycoside antibiotic. It works by stopping the growth of parasites in the intestines. This medication is poorly absorbed into the blood so it will not work for infections outside of the intestines.

Paromomycin may also be used along with a special diet to treat a certain serious brain problem (hepatic encephalopathy). This condition occurs in people with liver disease and is caused by too much of a certain natural substance (ammonia) in the body. Normally the liver gets rid of the ammonia. Paromomycin helps to treat hepatic encephalopathy by stopping the growth of certain bacteria in your intestines that make ammonia.

This antibiotic treats only parasitic and bacterial infections. It will not work for viral infections (such as common cold, flu). Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.

How should I take Paromomycin?

Take this medication by mouth with meals, usually 3 times daily (every 8 hours) or as directed by your doctor.

The dosage is based on your weight, medical condition, and response to treatment.

For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day.

Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a return of the infection.

Tell your doctor if your condition persists or worsens.

How do I store Paromomycin?

Paromomycin is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Paromomycin in the bathroom or the freezer. There may be different brands of Paromomycin that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Paromomycin down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Paromomycin?

Before taking paromomycin, tell your doctor or pharmacist if you are allergic to it; or to other aminoglycoside antibiotics (such as gentamicin, tobramycin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: intestinal problems (such as blockage, ulcers).

Paromomycin may cause live bacterial vaccines (such as typhoid vaccine) to not work as well. Do not have any immunizations/vaccinations while using this medication unless your doctor tells you to.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Paromomycin during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Paromomycin. Paromomycin is pregnancy risk category N according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Paromomycin?

Nausea, vomiting, loss of appetite, abdominal cramps, diarrhea, and heartburn may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if this unlikely but serious side effect occurs: oily stools.

Tell your doctor right away if any of these rare but seriousringing/roaring sounds in the ears, hearing loss, dizziness, numb/tingling skin, headache, seizures, muscle weakness.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Paromomycin?

Some products that may interact with this drug include: digoxin.

Paromomycin may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Paromomycin?

Paromomycin may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Paromomycin?

Paromomycin may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Paromomycin.

What is the dose of Paromomycin for an adult?

Usual Adult Dose for Amebiasis

25 to 35 mg/kg/day orally in 3 divided doses with meals for 5 to 10 days. Should be used following a course of metronidazole for the treatment of mild to severe, symptomatic disease. Paromomycin is not effective in extraintestinal amebiasis.

Usual Adult Dose for Cryptosporidiosis

25 to 35 mg/kg/day orally in 2 to 4 divided doses with meals for 10 to 14 days (investigational). Has occasionally been used for up to 4 to 6 weeks or longer in AIDS patients.

Usual Adult Dose for Dientamoeba fragilis

25 to 35 mg/kg/day orally in 3 divided doses with meals for 7 days (unlabeled use).

Usual Adult Dose for Giardiasis

25 to 35 mg/kg/day orally in 3 divided doses with meals for 7 days (investigational). Paromomycin is an alternative for the treatment of giardiasis. Metronidazole is generally considered the drug of choice.

Usual Adult Dose for Hymenolepis nana (Dwarf Tapeworm)

45 mg/kg orally once a day for 5 to 7 days (unlabeled use). Paromomycin is not the treatment of choice.

Usual Adult Dose for Diphyllobothrium latum (Fish Tapeworm)

1 g orally every 15 minutes for 4 doses (unlabeled use). Paromomycin is not the treatment of choice.

Usual Adult Dose for Dipylidium caninum (Dog Tapeworm)

1 g orally every 15 minutes for 4 doses (unlabeled use). Paromomycin is not the treatment of choice.

Usual Adult Dose for Taenia saginata (beef tapeworm)

1 g orally every 15 minutes for 4 doses (unlabeled use). Paromomycin is not the treatment of choice.

Usual Adult Dose for Taenia solium (pork tapeworm)

1 g orally every 15 minutes for 4 doses (unlabeled use). Paromomycin is not the treatment of choice.

Usual Adult Dose for Hepatic Coma

Adjunct therapy: 1 gram four times a day for 5 to 7 days

Renal Dose Adjustments

Data not available. Paromomycin is not absorbed systemically.

Liver Dose Adjustments

No adjustment recommended. Paromomycin does not undergo significant systemic absorption.

Precautions

Prolonged use may increase risk of ototoxicity.

Dialysis

No adjustment recommended. Paromomycin does not undergo significant systemic absorption.

What is the dose of Paromomycin for a child?

Usual Pediatric Dose for Amebiasis

<18 years: 25 to 35 mg/kg/day orally in 3 divided doses with meals for 5 to 10 days. Should be used following a course of metronidazole for the treatment of mild to severe, symptomatic disease. Paromomycin is not effective in extraintestinal amebiasis.

Usual Pediatric Dose for Cryptosporidiosis

25 to 35 mg/kg/day orally in 3 divided doses with meals for 10 to 14 days (investigational). Has occasionally been used for up to 4 to 6 weeks or longer in AIDS patients.

Usual Pediatric Dose for Dientamoeba fragilis

<18 years: 25 to 35 mg/kg/day orally in 3 divided doses with meals for 7 days (unlabeled use).

Usual Pediatric Dose for Giardiasis

<18 years: 25 to 35 mg/kg/day orally in 3 divided doses with meals for 7 days (investigational). Paromomycin is an alternative for the treatment of giardiasis. Metronidazole is generally considered the drug of choice.

Usual Pediatric Dose for Hymenolepis nana (Dwarf Tapeworm)

<18 years: 45 mg/kg orally once a day for 5-7 days (unlabeled use).

Usual Pediatric Dose for Diphyllobothrium latum (Fish Tapeworm)

<18 years: 11 mg/kg orally every 15 minutes for 4 doses (unlabeled use).

Usual Pediatric Dose for Dipylidium caninum (Dog Tapeworm)

<18 years: 11 mg/kg orally every 15 minutes for 4 doses (unlabeled use).

Usual Pediatric Dose for Taenia saginata (beef tapeworm)

<18 years: 11 mg/kg orally every 15 minutes for 4 doses (unlabeled use).

Usual Pediatric Dose for Taenia solium (pork tapeworm)

<18 years: 11 mg/kg orally every 15 minutes for 4 doses (unlabeled use).

How is Paromomycin available?

Paromomycin is available in the following dosage forms and strengths:

  • Oral capsule.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Paromomycin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: April 11, 2018 | Last Modified: April 11, 2018

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