Generic Name: Pancrelipase Brand Name(s): Generics only. No brands available.

Uses

What is pancrelipase used for?

Pancrelipase contains the enzymes needed for the digestion of proteins, starches, and fats, commonly used for improving food digestion in certain conditions (for example, cystic fibrosis, pancreatitis).

How should I take pancrelipase ?

For orally taken form, you should:

  • Take pancrelipase bymouth as directed by your doctor concerning: dose, schedule.
  • Read the label carefully before using pancrelipase.
  • Consult your doctor for any information on the label that you do not clearly understand.

How do I store pancrelipase?

Pancrelipaseis best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store pancrelipasein the bathroom or the freezer. There may be different brands of pancrelipase that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush pancrelipase down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using pancrelipase?

Before using pancrelipase, tell your doctor if:

  • You have allergic reaction to pancrelipase, excipients using for dosage form containing pancrelipase.
  • You have allergic reaction to any other medicines, foods, dyes, preservatives, or animals.
  • You have used any other health conditions, drugs that have a risk of interaction with pancrelipase.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using pancrelipase during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking pancrelipase. Pancrelipase is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from pancrelipase?

As taking others medicines, taking pancrelipase can cause some side effects. Most of them are rarely occurring and do not need any supplementary treatment. However, it is always important for you to consult your doctor if you have any problem after taking this medicine.

Some of side effects include:

  • Blurred vision
  • Dry mouth
  • Flushed, dry skin
  • Fruit-like breath odor
  • Headache
  • Increased hunger
  • Increased thirst
  • Increased urination
  • Sweating
  • Unexplained weight loss
  • Vomiting
  • Cough
  • Difficulty breathing
  • Difficulty swallowing
  • Dizziness
  • Fast heartbeat
  • Hives, itching, or skin rash
  • Nausea
  • Noisy breathing
  • Puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • Tightness in the chest
  • Trouble passing stool
  • Unusual or severe abdominal or stomach pain
  • Unusual tiredness or weakness

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with pancrelipase?

Pancrelipase may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with pancrelipase?

Pancrelipase may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with pancrelipase?

Pancrelipasemay interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions are:

  • Abnormal blood glucose levels
  • Fibrosing colonopathy (bowel disorder)
  • Gout
  • Hyperuricemia (high uric acid in the blood)
  • Hyperuricosuria (high uric acid in the urine)
  • Intestinal (bowel) blockage
  • Kidney disease
  • Pancreatitis (inflammation of the pancreas)
  • Allergy to pork products
  • Lactose intolerance

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using pancrelipase.

What is the dose of pancrelipase for an adult?

For capsule

The recommended dose is one to three capsules before or with meals and snacks.

For delayed-release capsules

The starting dose is 500 lipase units per kilogram (kg) of body weight per meal. The recommended maximum dose is not more than 2500 lipase units per kg of body weight per meal (or less than or equal to 10,000 lipase units per kg of body weight per day), or less than 4000 lipase units per gram (g) of fat ingested per day.

For powder

The recommended dose is 1/4 teaspoonful (0.7 gram) with meals and snacks.

For tablet:

The starting dose is 500 lipase units per kilogram (kg) of body weight per meal. The recommended maximum dose is usually not more than 2500 lipase units per kg of body weight per meal (or less than or equal to 10,000 lipase units per kg of body weight per day), or less than 4000 lipase units per gram (g) of fat ingested per day.

What is the dose of pancrelipase for a child?

For capsules:

The recommended dose is one to three capsules sprinkled on food at each meal.

For oral dosage form (delayed-release capsules):

Children older than 12 months and younger than 4 years of age: The starting dose is 1000 lipase units per kg of body weight per meal. The recommended maximum dose is usually not more than 2500 lipase units per kg of body weight per meal (or less than or equal to 10,000 lipase units per kg of body weight per day), or less than 4000 lipase units per gram (g) of fat ingested per day.

Infants younger than 12 months

  • Creon: The recommended dose is 3000 lipase units per 120 milliliters (ml) of infant formula or per breastfeeding.
  • Pancreaze: The recommended dose is 2600 lipase units per 120 ml of infant formula or per breastfeeding.
  • Pertzye: Use and dose must be determined by your doctor.
  • Ultresa™: Use and dose must be determined by your doctor.
  • Zenpep®: The recommended dose is 3000 lipase units per 120 mL of infant formula or per breastfeeding.

For powder:

The recommended dose is 1/4 teaspoonful with meals. Your doctor may adjust your dose if needed.

For tablets:

The recommended dose is one to two tablets with meals.

How is pancrelipase available?

Pancrelipase is available in the following dosage forms and strengths:

  • Capsule, Delayed Release
  • Tablet
  • Tablet, Chewable
  • Powder
  • Capsule

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of pancrelipase, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: February 18, 2017 | Last Modified: February 18, 2017

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