Generic Name: Oxybutynin Brand Name(s): Generics only. No brands available.

Uses

What is Oxybutynin used for?

Oxybutynin is a long-acting form of oxybutynin that is used to treat overactive bladder and urinary conditions. It relaxes the muscles in the bladder to help decrease problems of urgency and frequent urination. Oxybutynin belongs to a class of drugs known as antispasmodics.

This medication is also used to treat children 6 years of age and older who have an overactive bladder due to certain nerve disorders (e.g., spina bifida).

How should I take Oxybutynin?

Take this medication by mouth, usually once a day, or as directed by your doctor. It may be taken with or without food. The dosage is based on your medical condition and response to therapy. The length of treatment is determined by your doctor who may suggest periodic trials off the drug to evaluate whether you still need to be taking it.

Swallow this medication with the help of liquids. Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day.

Inform your doctor if your condition persists or worsens.

How do I store Oxybutynin?

Oxybutynin is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Oxybutynin in the bathroom or the freezer. There may be different brands of Oxybutynin that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Oxybutynin down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Oxybutynin?

Before taking oxybutynin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: active internal bleeding, untreated/uncontrolled glaucoma (narrow-angle), bladder disease (e.g., bladder outflow blockage, urinary retention), certain muscle disease (myasthenia gravis), heart disease (e.g., congestive heart failure, coronary artery disease, arrhythmias), high blood pressure, liver disease, kidney disease, loss of mental abilities (dementia), certain nervous system disorder (autonomic neuropathy), enlarged prostate gland (benign prostatic hyperplasia-BPH), stomach/intestinal disease (e.g., blockage, paralytic ileus, acid reflux disease, hiatal hernia, ulcerative colitis), overactive thyroid (hyperthyroidism), Parkinson’s disease.

This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This drug may increase the risk for heatstroke because it causes decreased sweating. Avoid becoming overheated in hot weather, saunas, and during exercise or other strenuous activity.

Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, constipation, trouble urinating. Drowsiness and confusion can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Oxybutynin during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Oxybutynin. Oxybutynin is pregnancy risk category B according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Oxybutynin?

Dry mouth, dizziness, drowsiness, blurred vision, dry eyes, nausea, vomiting, upset stomach, stomach pain, constipation, diarrhea, headache, unusual taste in mouth, dry/flushed skin, and weakness may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water or use a saliva substitute. To relieve dry eyes, use artificial tears or other eye lubricants. Consult your pharmacist for further advice.

To prevent constipation, maintain a diet adequate in fiber, drink plenty of water, and exercise. If you become constipated, consult your pharmacist for help in choosing a laxative (e.g., stimulant-type with stool softener).

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: decreased sexual activity, difficulty urinating, fast/pounding heartbeat, signs of kidney infection (such as burning/painful/frequent urination, lower back pain, fever), mental/mood changes (such as confusion, hallucinations), swelling of arms/legs/ankles/feet, vision problems (including eye pain), seizures, stomach/intestinal blockage (such as persistent nausea/vomiting, prolonged constipation).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Oxybutynin?

Some products that may interact with this drug include: pramlintide, drugs that can irritate the esophagus/stomach (such as potassium tablets/capsules, oral bisphosphonates including alendronate, etidronate), drugs that can cause dry mouth and constipation (including anticholinergic medications such as atropine/scopolamine, antihistamines such as diphenhydramine, other antispasmodics including dicyclomine, belladonna alkaloids)..

Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana, drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that can cause drowsiness, constipation or blurred vision. Ask your pharmacist about using those products safely.

Oxybutynin may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Oxybutynin?

Oxybutynin may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Oxybutynin?

Oxybutynin may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Oxybutynin.

What is the dose of Oxybutynin for an adult?

Usual Adult Dose for Urinary Incontinence

Immediate Release Tablets/Syrup/Solution:

Recommended dose: 5 mg orally 2 to 3 times a day

Maximum dose: 5 mg orally 4 times a day

Extended Release Tablets:

Recommended dose: 5 to 10 mg once a day at approximately the same time each day

Titration: The dose may be adjusted in 5 mg increments at approximately weekly intervals to achieve a balance of efficacy and tolerability

Maximum dose: 30 mg/day

Transdermal System (Patch):

Recommended dose: 3.9 mg/day applied to dry, intact skin on the abdomen, hip, or buttock twice weekly (every 3 or 4 days); a new application site should be selected with each new system to avoid reapplication to the same site within 7 days

Transdermal Gel 3%:

Recommended dose: 3 pumps (84 mg/day) applied once daily to clean, dry, intact skin on the abdomen, or upper arms/shoulders, or thighs; apply immediately after actuating the dose; application sites may be rotated to reduce the potential for local site reactions

Transdermal Gel 10%:

Recommended dose: The contents of one sachet applied once daily to dry, intact skin on the abdomen, upper arms/shoulders, or thighs; application sites should be rotated; application should not be made to the same site on consecutive days

Comments:

-Tablets should be swallowed whole, with water.

-In case of a missed dose, the patient should wait and take the next dose at the regular time.

-The patch should be applied to dry, intact skin on the abdomen, hip, or buttock immediately after removal from the protective sachet. A new application site should be selected with each new patch to avoid reapplication to the same site within 7 days.

Uses: For the relief of symptoms of bladder instability associated with voiding in patients with uninhibited neurogenic or reflex neurogenic bladder (i.e., urgency, frequency, urinary leakage, urge incontinence, dysuria); overactive bladder; urinary frequency; urinary incontinence

Usual Adult Dose for Urinary Frequency

Immediate Release Tablets/Syrup/Solution:

Recommended dose: 5 mg orally 2 to 3 times a day

Maximum dose: 5 mg orally 4 times a day

Extended Release Tablets:

Recommended dose: 5 to 10 mg once a day at approximately the same time each day

Titration: The dose may be adjusted in 5 mg increments at approximately weekly intervals to achieve a balance of efficacy and tolerability

Maximum dose: 30 mg/day

Transdermal System (Patch):

Recommended dose: 3.9 mg/day applied to dry, intact skin on the abdomen, hip, or buttock twice weekly (every 3 or 4 days); a new application site should be selected with each new system to avoid reapplication to the same site within 7 days

Transdermal Gel 3%:

Recommended dose: 3 pumps (84 mg/day) applied once daily to clean, dry, intact skin on the abdomen, or upper arms/shoulders, or thighs; apply immediately after actuating the dose; application sites may be rotated to reduce the potential for local site reactions

Transdermal Gel 10%:

Recommended dose: The contents of one sachet applied once daily to dry, intact skin on the abdomen, upper arms/shoulders, or thighs; application sites should be rotated; application should not be made to the same site on consecutive days

Comments:

-Tablets should be swallowed whole, with water.

-In case of a missed dose, the patient should wait and take the next dose at the regular time.

-The patch should be applied to dry, intact skin on the abdomen, hip, or buttock immediately after removal from the protective sachet. A new application site should be selected with each new patch to avoid reapplication to the same site within 7 days.

Uses: For the relief of symptoms of bladder instability associated with voiding in patients with uninhibited neurogenic or reflex neurogenic bladder (i.e., urgency, frequency, urinary leakage, urge incontinence, dysuria); overactive bladder; urinary frequency; urinary incontinence

Usual Adult Dose for Neurogenic Bladder

Immediate Release Tablets/Syrup/Solution:

Recommended dose: 5 mg orally 2 to 3 times a day

Maximum dose: 5 mg orally 4 times a day

Extended Release Tablets:

Recommended dose: 5 to 10 mg once a day at approximately the same time each day

Titration: The dose may be adjusted in 5 mg increments at approximately weekly intervals to achieve a balance of efficacy and tolerability

Maximum dose: 30 mg/day

Transdermal System (Patch):

Recommended dose: 3.9 mg/day applied to dry, intact skin on the abdomen, hip, or buttock twice weekly (every 3 or 4 days); a new application site should be selected with each new system to avoid reapplication to the same site within 7 days

Transdermal Gel 3%:

Recommended dose: 3 pumps (84 mg/day) applied once daily to clean, dry, intact skin on the abdomen, or upper arms/shoulders, or thighs; apply immediately after actuating the dose; application sites may be rotated to reduce the potential for local site reactions

Transdermal Gel 10%:

Recommended dose: The contents of one sachet applied once daily to dry, intact skin on the abdomen, upper arms/shoulders, or thighs; application sites should be rotated; application should not be made to the same site on consecutive days

Comments:

-Tablets should be swallowed whole, with water.

-In case of a missed dose, the patient should wait and take the next dose at the regular time.

-The patch should be applied to dry, intact skin on the abdomen, hip, or buttock immediately after removal from the protective sachet. A new application site should be selected with each new patch to avoid reapplication to the same site within 7 days.

Uses: For the relief of symptoms of bladder instability associated with voiding in patients with uninhibited neurogenic or reflex neurogenic bladder (i.e., urgency, frequency, urinary leakage, urge incontinence, dysuria); overactive bladder; urinary frequency; urinary incontinence

Renal Dose Adjustments

Caution is recommended

Liver Dose Adjustments

Caution is recommended

Other Comments

Administration advice:

-Swallow extended release tablets whole; do not chew, crush, or divide. Extended release tablets may be taken with or without food, at the same time each day.

-The tablet/syrup/solution formulations should be taken with food or milk to decrease GI distress.

-The transdermal system should be applied on the abdomen, hip, or buttock to skin that is dry and intact. Application sites should be rotated to avoid local skin reactions. Do not apply the system to the same site within 7 days.

Monitoring:

-NERVOUS SYSTEM: Monitor for signs of anticholinergic effects in first few months of beginning treatment or increasing dosage.

Patient advice:

-Heat prostration (fever and heat stroke due to decreased sweating) can occur when this drug is administered in the presence of high environmental temperature.

-Patients should be advised to exercise caution because this drug can cause drowsiness (somnolence) or blurred vision.

-Alcohol may enhance the drowsiness caused by this drug.

-In case of a missed dose, the patient should wait and take the next dose at the regular time.

-The extended-release formulation is contained within a nondeformable material that is eliminated from the body and may appear in the stool.

-This drug is associated with anticholinergic central nervous system (CNS) effects, including hallucinations, agitation, confusion, and somnolence.

-Drowsiness and blurred vision may affect mental alertness and work performance. Alcohol and other sedative medications may exacerbate the drowsiness.

What is the dose of Oxybutynin for a child?

Usual Pediatric Dose for Urinary Incontinence

Immediate Release Tablets/Syrup/Solution:

Pediatric patients over 5 years of age:

-Usual dose: 5 mg orally 2 times a day

-Maximum dose: 5 mg orally 3 times a day

Extended Release Tablets:

Pediatric patients over 6 years of age:

-Initial dose: 5 mg orally once a day at approximately the same time each day; the dosage may be adjusted in 5 mg increments to achieve a balance of efficacy and tolerability

-Maximum dose: 15 mg orally per day

Comments:

-Tablets should be swallowed whole, with water.

-In case of a missed dose, the patient should wait and take the next dose at the regular time.

Uses:

-Immediate Release Tablets/Syrup/Solution: For the relief of symptoms of bladder instability associated with voiding in patients with uninhibited neurogenic or reflex neurogenic bladder (i.e., urgency, frequency, urinary leakage, urge incontinence, dysuria) in patients 5 years of age and older.

-Extended Release Tablets: For the treatment of pediatric patients aged 6 years and older with symptoms of detrusor overactivity associated with a neurological condition (e.g., spina bifida).

Usual Pediatric Dose for Urinary Frequency

Immediate Release Tablets/Syrup/Solution:

Pediatric patients over 5 years of age:

-Usual dose: 5 mg orally 2 times a day

-Maximum dose: 5 mg orally 3 times a day

Extended Release Tablets:

Pediatric patients over 6 years of age:

-Initial dose: 5 mg orally once a day at approximately the same time each day; the dosage may be adjusted in 5 mg increments to achieve a balance of efficacy and tolerability

-Maximum dose: 15 mg orally per day

Comments:

-Tablets should be swallowed whole, with water.

-In case of a missed dose, the patient should wait and take the next dose at the regular time.

Uses:

-Immediate Release Tablets/Syrup/Solution: For the relief of symptoms of bladder instability associated with voiding in patients with uninhibited neurogenic or reflex neurogenic bladder (i.e., urgency, frequency, urinary leakage, urge incontinence, dysuria) in patients 5 years of age and older.

-Extended Release Tablets: For the treatment of pediatric patients aged 6 years and older with symptoms of detrusor overactivity associated with a neurological condition (e.g., spina bifida).

Usual Pediatric Dose for Neurogenic Bladder

Immediate Release Tablets/Syrup/Solution:

Pediatric patients over 5 years of age:

-Usual dose: 5 mg orally 2 times a day

-Maximum dose: 5 mg orally 3 times a day

Extended Release Tablets:

Pediatric patients over 6 years of age:

-Initial dose: 5 mg orally once a day at approximately the same time each day; the dosage may be adjusted in 5 mg increments to achieve a balance of efficacy and tolerability

-Maximum dose: 15 mg orally per day

Comments:

-Tablets should be swallowed whole, with water.

-In case of a missed dose, the patient should wait and take the next dose at the regular time.

Uses:

-Immediate Release Tablets/Syrup/Solution: For the relief of symptoms of bladder instability associated with voiding in patients with uninhibited neurogenic or reflex neurogenic bladder (i.e., urgency, frequency, urinary leakage, urge incontinence, dysuria) in patients 5 years of age and older.

-Extended Release Tablets: For the treatment of pediatric patients aged 6 years and older with symptoms of detrusor overactivity associated with a neurological condition (e.g., spina bifida).

Precautions

-Tablet/Syrup/Solution formulation: Safety and efficacy have not been established in patients younger than 5 years.

-Extended-release formulation: Safety and efficacy have not been established in patients younger than 6 years.

-Patch or gel formulation: Safety and efficacy have not been established in patients younger than 18 years.

How is Oxybutynin available?

Oxybutynin is available in the following dosage forms and strengths:

  • Transdermal gel,
  • Oral syrup,
  • Oral tablet,
  • Oral tablet, extended release,
  • Transdermal film, extended release.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Oxybutynin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

 

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: April 5, 2018 | Last Modified: April 5, 2018

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